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Centrophenoxine-induced increase of beta-adrenoceptor density in brain cortex of old mice.

Abstract：

:The influence of centrophenoxine treatment on beta-adrenoceptor density has been studied in the brain cortex of old mice. One group of 21-mth-old mice was injected intraperitoneally with 3.8 mg/day centrophenoxine daily for 5 days. A second group received the same daily treatment for 40 days. Two other groups of untreated mice of the same age served as controls. Receptor affinity showed no statistically significant changes in the four different groups investigated. As regards the receptor density, an increasing trend has been elicited between the 5-day treated mice and their controls; however, the increase was not statistically significant. The second group of old mice treated with centrophenoxine for 40 days exhibited a statistically significant increase in receptor density when compared with untreated animals. The modulation of beta-adrenoceptor density may be explained as the result of either a direct action on synaptic structure or an indirect effect mediated by thyroid hormones.

journal_name

Arch Gerontol Geriatr

journal_title

Archives of gerontology and geriatrics

authors

Viticchi C,Gentile S,Piantanelli L

doi

10.1016/0167-4943(84)90017-7

subject

Has Abstract

pub_date

1984-05-01 00:00:00

pages

77-82

issue

1

eissn

0167-4943

issn

1872-6976

pii

0167494384900177

journal_volume

3

pub_type

杂志文章

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