Abstract：
:Aging hallmarks include decreased progenitor cell functions. The Wnt/β-catenin signaling pathway has emerged as a key player in cellular aging in recent years. Wnt activity changes in aged tissues including skin, serum, muscle and artery. In heart, it is hypothesized that Wnt signaling increases with aging and this signaling drives cardiac progenitor cells into fibrogenic lineage. However, experimental evidence supporting this hypothesis has not been established. Here we take a bioinformatics data mining approach, utilizing pre-existing data, to study cardiac aging gene expression data in mice. Contrary to the hypothesis, our study shows that the Wnt/β-catenin signaling is down-regulated in aged heart in mice. Nutrition treatment, with calorie restriction and Resveratrol supplementation, known to retard aging, opposes heart aging by restoring Wnt/β-catenin signaling level in the old heart. In addition, the expression of β-catenin gene, a key regulator of the Wnt/β-catenin signaling pathway, decreases up to 3-fold in aged heart, but is restored to levels found in young heart with methods of nutrition intervention. Combined with database search, our study suggests that some of bioflavonoids may have potential therapeutic benefits to heart aging.
journal_name
Arch Gerontol Geriatrjournal_title
Archives of gerontology and geriatricsauthors
Li Q,Hannah SSdoi
10.1016/j.archger.2012.06.013subject
Has Abstractpub_date
2012-11-01 00:00:00pages
749-54issue
3eissn
0167-4943issn
1872-6976pii
S0167-4943(12)00137-9journal_volume
55pub_type
杂志文章abstract：:Self-rated health is a strong predictor of mortality, morbidity, future functional capacity and the quality of life. Measures of self-rated health have been collected fairly regularly since the 1980s, but few of them focus on self-rated health among the elderly war veterans. The aim of this study was to examine change...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2011.09.011
更新日期：2012-09-01 00:00:00
abstract：:This report assesses associations between trajectories of psychosocial experience over the life course and cognitive function in late life men. Survey data from the National Longitudinal Study of Older Men, a community sample of 1835 United States men aged 45-59 years in 1966, are used to explore the cognitive effects...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(03)00046-3
更新日期：2003-09-01 00:00:00
abstract：:Age-related macular degeneration (ARMD) is one of the leading causes of vision impairment in the elderly and its frequency in general population increases with aging. The etiology of this disease has remained so far unknown. The relationship between ARMD and diabetes mellitus was studied in the present work. Fundus oc...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/0167-4943(96)86985-8
更新日期：1996-01-01 00:00:00
abstract：:Leisure time represents an important part of the so-called 'successful aging' and contributes to overcome the problems related to the reduction of the social roles, favoring a better subjective adaptation to old age. In this work we observed the elderly population frequenting our Day Hospital, by estimating the affect...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(01)00111-x
更新日期：2001-09-01 00:00:00
abstract：:The experimental suitability of the flour beetles of the genus Tribolium has attracted ecologists, nutritionists, radiation biologists and geneticists for decades. I have, recently, evaluated their importance to gerontologists. This paper deals with age-related changes and parental age effects which were not included ...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/0167-4943(87)90038-0
更新日期：1987-04-01 00:00:00
abstract：OBJECTIVES:This study aims to analyze the accuracy and predictive ability of the Risk Instrument for Screening in the Community (RISC) scored by general practitioners (GPs) in a sample of primary care patients aged 80+ with perceived mental health concerns. METHOD:GPs ranked the perceived risk of the three adverse out...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2019.103974
更新日期：2020-01-01 00:00:00
abstract：:Alzheimer Disease (AD) is an age-related dementia that is going to assume the characteristics of a health emergency. A reliable diagnosis of AD, especially at the very onset, is complicated. Moreover, it is known that about 20% of patients in hospital for Alzheimer-type dementia have unusual clinical symptoms and some...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(98)00017-x
更新日期：1998-07-01 00:00:00
abstract：OBJECTIVE:To investigate the association between frailty and a summary cardiovascular risk measure (Framingham Risk Score, FRS) in a sample of older adults from different epidemiologic contexts participating in the multicenter International Mobility in Aging Study (IMIAS). MATERIAL AND METHODS:This cross-sectional stu...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2020.104279
更新日期：2021-01-01 00:00:00
abstract：:The objective of this study was to further test the hypothesis that aging in the housefly is associated with increased oxidative stress. Age-related changes in the concentration of glutathione, NAD and NADP, which undergo oxidation-reduction reactions, and of H2O2, a potent cellular oxidant, were examined in the homog...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/0167-4943(87)90001-x
更新日期：1987-07-01 00:00:00
abstract：:Renal function is often altered in elderly patients. A lot of formulae are proposed to estimate GFR to adjust drug posology. French guidelines recommend the Cockcroft-Gault formula corrected with the body surface area (cCG), but the initially described unadjusted Cockcroft-Gault equation (CG) is mainly used in geriatr...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2009.05.010
更新日期：2010-05-01 00:00:00
abstract：:Previous studies have demonstrated that sleep-related problems are common in the aging process. Such problems are greater in nursing home residents than other elderly people. This study had the following objectives: (1) establish the clinical profile of nursing home residents according to their quality of sleep and in...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2012.11.011
更新日期：2013-05-01 00:00:00
abstract：:This study investigates the implications of different levels of cognitive decline on functional status in frail older adults. Four cognitive trajectories, including two with catastrophic cognitive decline, were defined in a 3-year study. Participants with complete cognitive and functional status data at baseline, 12 a...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2007.09.007
更新日期：2009-01-01 00:00:00
abstract：:The appearance of diabetes in advanced age may be considered as a part of the involutive processes of aging, and as such, it might have a pathogenesis completely different from that of type 2 diabetes of medium age. As a matter of fact, it has been observed that the pancreas undergoes numerous structural and functiona...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(00)00088-1
更新日期：2001-03-01 00:00:00
abstract：:Although otherwise extensively researched, one aspect of social functioning in older people that has received less attention is its association with staying at home for as long as possible. This 10-year follow-up examines factors of social functioning that support older people's independent living in their own homes a...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2007.12.001
更新日期：2009-03-01 00:00:00
abstract：PURPOSE:Geriatric depression is now very common and leads to significant economic costs and family burden in China. Families with a depressed patient often report problematic family functioning in Western samples, and lack of social support is strongly associated with geriatric depression. However, the relationship bet...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2012.06.011
更新日期：2012-11-01 00:00:00
abstract：:A randomised controlled trial was conducted to assess whether a single intervention by a health visitor reduced the unplanned re-admission of elderly people discharged from geriatric wards. Two hundred and four consecutive discharges from geriatric wards were randomly allocated to receive either a single visit from th...
journal_title：Archives of gerontology and geriatrics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0167-4943(94)90044-2
更新日期：1994-01-01 00:00:00
abstract：:Insomnia is a significant problem that may jeopardize elderly residents' quality of life in long-term care settings. However, there are only a few studies dealing with sleeping disturbances among nursing home residents. The goal of this study was to determine the prevalence of insomnia and its associated factors in nu...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2005.06.008
更新日期：2006-01-01 00:00:00
abstract：:It is well established that cerebral white matter lesions (WML), present in the majority of older adults, are associated with cardiovascular and cerebrovascular diseases and also with cognitive decline. However, much less is known about how WML are related to other important individual characteristics and about the ge...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2018.06.010
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:To investigate the sex-difference in relation to the association between moderate-vigorous physical activity (MVPA) and sedentary time (ST) patterns with frailty. METHOD:Accelerometry from ≥50 year olds from the National Health and Nutrition Examination Survey (2003-04/2005-06 cycles) were included. Bouted a...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2019.103972
更新日期：2020-01-01 00:00:00
abstract：:In an obese hypertensive woman affected by angina-like chest pain, a physical training program and a low caloric diet resulted in a notable improvement of the anthropometric indexes, hyperinsulinemia, myocardial perfusion and left ventricular mass. ...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/0167-4943(96)86995-0
更新日期：1996-01-01 00:00:00
abstract：:Aging is a well-known risk factor associated with oral diseases. The aim of this cross-sectional study was to compare tooth loss and periodontal health between the relatively young elderly (65-74 years) and the old elderly (≥ 75 years) and to investigate the strength of the age effect on oral health status in the Kore...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2011.04.021
更新日期：2011-09-01 00:00:00
abstract：:The purpose of the present study was to investigate whether (a) the Adlerian construct of activity and social interest would be related to decreased depression and (b) meaning in life would mediate these relationships among Korean retirees. A total of 219 Korean retirees who had retired within the last three years com...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2015.07.003
更新日期：2015-11-01 00:00:00
abstract：:Hip fractures are a burden to both society and the individual. The aim of this study was to describe the frequency of osteoporosis and the in-hospital treatment costs of patients with hip fractures admitted to Hacettepe University Faculty of Medicine Hospital. Patients with a hip fracture who were admitted to the Orth...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2009.04.010
更新日期：2010-05-01 00:00:00
abstract：:According to the 'Hayflick limit', human fetal fibroblasts have a uniform, limited replicative lifespan of about 50 population doublings in cell culture. This concept was extrapolated to diverse cells in the body. It seemed to decrease with the age of the cell donor and, as a form of cell senescence, was thought to un...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(01)00221-7
更新日期：2002-05-01 00:00:00
abstract：:The aim was to determine the validity and usefulness of hand-held dynamometry for measuring muscle strength in independent community-dwelling older persons. Cross-sectional study was performed in 281 subjects aged over 65, mean age of 74.3 years. The strength of six muscle groups was measured in three consecutive atte...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2011.02.006
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:C-reactive protein (CRP), an important inflammatory biomarker, has been linked to various diseases (e.g., cardiovascular disease). Here, we aimed to investigate the associations of high sensitivity C-reactive protein (hsCRP) with frailty and overnight hospital admission in an elderly Chinese population. MET...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/j.archger.2015.08.009
更新日期：2016-05-01 00:00:00
abstract：:Few studies have examined the association between perioperative blood transfusion and postoperative delirium (POD) in aged patients undergoing total hip replacement surgery. In this prospective study, 186 patients older than 65 years undergoing elective unilateral total hip replacement surgery were enrolled. Of those,...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.archger.2014.03.009
更新日期：2014-07-01 00:00:00
abstract：:A study of the intracellular distribution of prion protein (PrP) in N2a neuroblastoma cells which had been infected with prions (ScN2a cells) revealed that most PrP is present in the cytoplasm. However, a significant amount of PrP is also present in the nucleus (predominantly in the nucleoli) of these cells, as analyz...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/s0167-4943(96)00770-4
更新日期：1997-07-01 00:00:00
abstract：:In a study of ten young and seven elderly healthy men we have performed an oral glucose tolerance test (75 g) and employed a euglycemic hyperinsulinemic (0.25 mUx kg/min) glucose clamp technique in order to determine insulin sensitivity. This latter experimental protocol consisted of 120 min of euglycemic clamp follow...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章
doi：10.1016/0167-4943(90)90026-3
更新日期：1990-05-01 00:00:00
abstract：BACKGROUND:Hemodialysis patients in Japan are aging, but the influence of lifestyle factors on EuroQoL 5-Dimension 5-Level (EQ-5D-5 L) scores in older hemodialysis patients is unclear. This study aimed to measure health-related quality of life using the EQ-5D-5 L for older hemodialysis patients and to identify the life...
journal_title：Archives of gerontology and geriatrics
pub_type： 杂志文章,评审
doi：10.1016/j.archger.2018.06.006
更新日期：2018-01-01 00:00:00
