Abstract：
:Idoxuridine (IDU) and adenine arabinoside (Ara-A) are less than ideal drugs for the treatment of herpes because of toxicity, only partial efficacy with initial dendritic ulcers, and insufficient antiviral activity to prevent occasional epithelial breakthrough. Trifluorothymidine (TFT), soon to be released by the FDA for general use, appears to be more effective, curing 97% of ulcers in two weeks, and healing large ameboid ulcers more rapidly. Acycloguanosine, in combination with Ara-A, virtually eliminates stromal disease in rabbit eyes. A major advantage of this drug is its apparent lack of systemic toxicity due to its ability to interfere with the replication of virus-infected cells while not harming normal cells. Acycloguanosine should be available as an orally active, highly effective antiviral agent that can be given on an outpatient basis to treat deep infections. A new approach to the prevention of herpes recurrence involves the recognition that some isolates of herpes are mild or avirulent. Initial infection with avirulent virus may protect against virulent infection and yet may not cause disease. If such differences in virulence can be correlated with biochemical differences among the strains, prevention and treatment of herpes may be possible through manipulation of these metabolic pathways or immunization with avirulent virus.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Kaufman HEdoi
10.1016/s0161-6420(80)35273-1subject
Has Abstractpub_date
1980-02-01 00:00:00pages
135-9issue
2eissn
0161-6420issn
1549-4713pii
S0161-6420(80)35273-1journal_volume
87pub_type
杂志文章相关文献
OPHTHALMOLOGY文献大全abstract：OBJECTIVE:To test an educational intervention promoting the purchase of spectacles among Chinese children. DESIGN:Randomized, controlled trial. PARTICIPANTS:Children in years 1 and 2 of all 20 junior and senior high schools (ages 12-17 years) in 3 rural townships in Guangdong, China. METHODS:Children underwent visua...
journal_title：Ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ophtha.2011.06.016
更新日期：2011-12-01 00:00:00
abstract：:Rhabdomyosarcoma is the most common malignant orbital tumor of childhood. It has twice been reported to arise within the globe from the iris. In addition, teratoid medulloepithelioma, a tumor arising from the ciliary epithelium, can contain a rhabdomyoblastic component, often in combination with other heteroplastic el...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(90)32386-2
更新日期：1990-11-01 00:00:00
abstract：PURPOSE:To investigate the distribution of the eye's higher-order aberrations in postoperative laser refractive surgery patients with visual complaints and highly irregular corneal shapes. DESIGN:Retrospective case-control study. PARTICIPANTS:Thirty-three symptomatic postoperative LASIK and/or photorefractive keratec...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2005.04.022
更新日期：2005-10-01 00:00:00
abstract：PURPOSE:We report 2 cases of compressive optic neuropathy after use of oxidized regenerated cellulose (ORC) in orbital surgery. To our knowledge, no complications have been reported previously after use of this material in orbital surgery. We also review the complications related to its retention at operative sites out...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2005.11.003
更新日期：2006-02-01 00:00:00
abstract：PURPOSE:To determine the clinical efficacy of modified deep lamellar keratoplasty for the treatment of advanced-stage keratoconus with steep curvature. DESIGN:Retrospective, noncomparative clinical trial. PARTICIPANTS:Fifty-nine keratoconus patients with a curvature of more than 60 diopters (D) in 65 eyes were studie...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/j.ophtha.2009.07.005
更新日期：2010-02-01 00:00:00
abstract：PURPOSE:To evaluate the growth of geographic atrophy (GA) during anti-vascular endothelial growth factor (VEGF) therapy. DESIGN:Cohort within a clinical trial. PARTICIPANTS:Patients included in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT). METHODS:Participants were randomly assigned to...
journal_title：Ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ophtha.2014.11.007
更新日期：2015-04-01 00:00:00
abstract：OBJECTIVE:To compare the visual outcome, neodymium:YAG (Nd:YAG) capsulotomy rates, and percentage of posterior capsular opacification (PCO) seen with polymethylmethacrylate (PMMA), silicone, and polyacrylic intraocular lens implants 3 years after surgery. DESIGN:Randomized, prospective trial. PARTICIPANTS:Ninety eyes...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/S0161-6420(99)90047-7
更新日期：1999-01-01 00:00:00
abstract：PURPOSE:The purpose of this study is to determine if an endoscope would improve visualization of the anterior chamber angle and facilitate goniotomy in a surgical cloudy corneal model of primary infantile glaucoma. METHODS:A 23-gauge needle coupled to a 0.8-mm diameter flexible endoscope entered the anterior chamber o...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
abstract：:Testing with the Cochet-Bonnet esthesiometer revealed a strong correlation between corneal sensitivity and retinal status in a group of diabetic patients. Eyes with normal fundi had normal corneal sensitivity. Those with background retinopathy had somewhat poliferative retinopathyl showed a greater loss of sensitivity...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(80)35257-3
更新日期：1980-03-01 00:00:00
abstract：OBJECTIVE:To report clinical findings of rare retrobulbar optic nerve hemangioblastomas associated with von Hippel-Lindau disease (VHL). DESIGN:Retrospective observational case series. PARTICIPANTS:Nine patients with VHL. METHODS:The clinical course and magnetic resonance imaging findings of patients with VHL and he...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2008.01.027
更新日期：2008-08-01 00:00:00
abstract：OBJECTIVE:This study evaluated the predictability, stability, and safety of laser in situ keratomileusis (LASIK) in myopia and myopic astigmatism. DESIGN:The study design was a prospective, unmasked, nonrandomized clinical trial. PARTICIPANTS:Participating were 25 patients with myopia (37 eyes) with astigmatism of le...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/S0161-6420(98)95040-0
更新日期：1998-05-01 00:00:00
abstract：PURPOSE:To report the 3-month results of a randomized trial (Femtosecond Laser-Assisted Cataract Trial [FACT]) comparing femtosecond laser-assisted cataract surgery (FLACS) with standard phacoemulsification cataract surgery (PCS). DESIGN:Multicenter, randomized controlled trial funded by the UK National Institute of H...
journal_title：Ophthalmology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.ophtha.2020.02.028
更新日期：2020-08-01 00:00:00
abstract：PURPOSE:To evaluate the learning curve in Descemet's membrane endothelial keratoplasty (DMEK) in the management of corneal endothelial disorders. DESIGN:Retrospective, nonrandomized, clinical study at a tertiary referral center. PARTICIPANTS:We included 135 eyes of 118 patients with Fuchs' endothelial dystrophy. MET...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1016/j.ophtha.2011.03.037
更新日期：2011-11-01 00:00:00
abstract：:Asymptomatic hyperdeviation (HD) in peripheral gaze may be caused by muscle paresis, restrictive orbital diseases, cranial neuropathy, or skew deviation. The authors suspected that this finding was often physiologic and therefore examined 61 normal subjects with the Maddox rod. Forty-seven of 61 patients (77%) showed ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(88)33108-8
更新日期：1988-06-01 00:00:00
abstract：OBJECTIVE:The purpose of the study was to demonstrate that the arteriovenous shunt at the arteriovenous crossing could occur in major retinal vascular diseases other than Takayasu disease. DESIGN:Clinical review of consecutive case series. PARTICIPANTS:The authors studied 1885 eyes with retinal vascular diseases such...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/S0161-6420(98)97030-0
更新日期：1998-07-01 00:00:00
abstract：PURPOSE:The expression of cellular adhesion molecules in 31 penetrating keratoplasty specimens from a broad range of corneal inflammatory diseases was studied using monoclonal antibodies and an immunoperoxidase technique. METHODS:Corneas were divided into noninflamed, mild to moderately inflamed, and severely inflamed...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(94)31370-4
更新日期：1994-01-01 00:00:00
abstract：PURPOSE:To present a previously unreported African American family with 1 variation and 1 mutation of the homeobox transcription factor gene, VSX1 (RINX), and to describe the clinical features of family members. DESIGN:Family genotype and clinical studies. PARTICIPANTS:A 3-generation family with 7 available family me...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2003.07.006
更新日期：2004-04-01 00:00:00
abstract：:Intraocular lenses have been regulated by the Bureau of Devices of the Food and Drug Administration since February 9, 1978. One year ago, data were reported through August 9, 1979, at which time more than 177,000 lenses of four different classes had been implanted. In the meantime, appeals and legal action by the Publ...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(81)35014-3
更新日期：1981-05-01 00:00:00
abstract：OBJECTIVE:To establish an objective ophthalmic surgical evaluation protocol to assess residents' surgical competency and improve residents' surgical outcomes. PARTICIPANTS:Eight experts in resident education from comprehensive ophthalmology, cornea, glaucoma, and retina services; 2 chief residents (postgraduate year 5...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2005.01.045
更新日期：2005-07-01 00:00:00
abstract：PURPOSE:To investigate whether vascular endothelial growth factor (VEGF) or soluble intercellular adhesion molecule 1 (sICAM-1) is related to diabetic macular edema (DME). DESIGN:Retrospective case-control study. PARTICIPANTS:Thirty-three patients who had DME and 13 patients with nondiabetic ocular disease (control g...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2004.11.045
更新日期：2005-05-01 00:00:00
abstract：:Arteriohepatic dysplasia (AHD, Alagille's syndrome) is presumed to be one of the six known familial intrahepatic cholestatic syndromes, all of which present with neonatal jaundice or failure to thrive, or both. Accurate early diagnosis of the proper syndrome is important, as arteriohepatic dysplasia has a good prognos...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(81)35026-x
更新日期：1981-04-01 00:00:00
abstract：:A 38-year-old male homosexual with the new Acquired Immunodeficiency Syndrome (AIDS) had biopsy proven Kaposi's sarcoma of the right palpebral conjunctiva, extraocular mucocutaneous areas, and lymph nodes. Histologically, the palpebral tumor was characterized by atypical spindle cell proliferation and multiple slit-li...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(83)80011-6
更新日期：1983-08-01 00:00:00
abstract：:Light, fluorescent, and scanning and transmission electron microscopic examinations of two postmortem eyes from a 24-year-old man with well-documented fundus flavimaculatus with atrophic macular degeneration revealed striking abnormalities in the retinal pigment epithelium (RPE). Beginning near the equator, scanning e...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(80)35106-3
更新日期：1980-12-01 00:00:00
abstract：BACKGROUND:Malignant glaucoma (ciliary block glaucoma; aqueous misdirection glaucoma) is an incompletely understood, rare and serious complication of intraocular surgery. METHODS:A woman with pseudophakic malignant glaucoma underwent successful neodymium: YAG (Nd:YAG) laser photodisruption of the anterior hyaloid face...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(93)31479-x
更新日期：1993-09-01 00:00:00
abstract：OBJECTIVE:To describe presenting and corrected visual acuities after cataract surgery in a nationally representative sample of adults. Another objective was to describe refractive errors in operated eyes and to determine the optimal range of intraocular lens (IOL) powers for this population. DESIGN:Cross-sectional, po...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/j.ophtha.2010.08.025
更新日期：2011-04-01 00:00:00
abstract：PURPOSE:To analyze a phenomenon seen in patients with acquired immune deficiency syndrome (AIDS) with cytomegalovirus (CMV) retinitis undergoing systemic antiviral treatment: a persistent white border opacification on the edge of healed CMV retinitis. PATIENTS AND METHODS:The authors prospectively evaluated a populati...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(92)31804-4
更新日期：1992-09-01 00:00:00
abstract：:The authors compared the additive intraocular pressure (IOP)-lowering effects of two different topical medications, apraclonidine hydrochloride and dipivefrin hydrochloride, when used in conjunction with timolol maleate. Eighteen patients with elevated IOPs entered a randomized, double-masked, cross-over study. Each u...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0161-6420(89)32977-0
更新日期：1989-01-01 00:00:00
abstract：:One hundred sixty eyes of 92 patients with diffuse diabetic maculopathy with or without cystoid macular edema were enrolled in a prospective randomized clinical trial to determine the efficacy of "modified grid" argon (blue-green) laser photocoagulation. At the 12- and 24-month follow-ups, visual acuity significantly ...
journal_title：Ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0161-6420(86)33638-8
更新日期：1986-07-01 00:00:00
abstract：PURPOSE:To detect changes in the compliance and baseline position (position at the baseline time point of a compliance test) of the monkey optic disc after the onset of chronic experimental glaucoma. METHODS:Sixty-six compliance tests were performed on 26 eyes of 13 monkeys. Longitudinal Study. In seven normal monkeys...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(95)30791-9
更新日期：1995-12-01 00:00:00
abstract：OBJECTIVE:To investigate the risk factors and control mechanisms used to control the outbreak of diffuse lamellar keratitis (DLK) associated with laser in situ keratomileusis (LASIK) and examine the relationship between DLK and endotoxins released from sterilizer biofilm reservoirs. DESIGN:Clinic-based cohort and labo...
journal_title：Ophthalmology
pub_type： 杂志文章
doi：10.1016/s0161-6420(00)00246-3
更新日期：2000-07-01 00:00:00
