3-Methyl-4-nitrophenol metabolism by uridine diphosphate glucuronosyltransferase and sulfotransferase in liver microsomes of mice, rats, and Japanese quail (Coturnix japonica).

Abstract:

:3-Methyl-4-nitrophenol (PNMC) is a component of diesel exhaust particles and one of the major breakdown products of the insecticide fenitrothion. This chemical has a high potential for reproductive toxicity in Japanese quail (Coturnix japonica) and rats. Because PNMC inhaled by the body is metabolized by uridine diphosphate glucuronosyltransferase (UGT) and sulfotransferase, we investigated these enzyme activities in the hepatic microsomes and cytosols of quail (as a model of wild birds) and compared these activities with those of rats and mice as models of ecological and human risk assessment. The maximum velocity of the UGT for PNMC in quail was 12.7 nmol/min/mg, which was one third and one fourth those of rats and mice, respectively. The Michaelis-Menten constant of UGT for PNMC in quail was 0.29 mM, which was 1.3- and 1.8-fold higher than that in mice and rats, respectively, but not significantly different. In accordance with these results, UGT activities for PNMC were lowest in quail, with those in mice and rats being 4.4- and 2.7-fold higher, respectively. Sulfotransferase activity for PNMC was considerably less than that of UGT in all animals, including quail; no significant differences in the activities were found among mice, rats, and quail. These results suggest that glucuronidation may be involved primarily in PNMC elimination from wild birds as well as mammals and that the UGT activity in quail is less than that in the rodents.

journal_name

Environ Toxicol Chem

authors

Lee CH,Kamijima M,Li C,Taneda S,Suzuki AK,Nakajima T

doi

10.1897/07-034R1.1

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

1873-8

issue

9

eissn

0730-7268

issn

1552-8618

pii

07-034

journal_volume

26

pub_type

杂志文章
  • Effects of metals on enantioselective toxicity and biotransformation of cis-bifenthrin in zebrafish.

    abstract::Co-occurrence of pyrethroids and metals in watersheds previously has been reported to pose great risk to aquatic species. Pyrethroids are a class of chiral insecticides that have been shown to have enantioselective toxicity and biotransformation. However, the influence of metals on enantioselectivity of pyrethroids ha...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.3747

    authors: Yang Y,Ji D,Huang X,Zhang J,Liu J

    更新日期:2017-08-01 00:00:00

  • Biomagnification and tissue distribution of perfluoroalkyl substances (PFASs) in market-size rainbow trout (Oncorhynchus mykiss).

    abstract::The present study investigated the biomagnification potential as well as the substance and tissue-specific distribution of perfluoroalkyl substances (PFASs) in market-size rainbow trout (Oncorhynchus mykiss). Rainbow trout with an average body weight of 314 ± 21 g were exposed to perfluorobutane sulfonate (PFBS), perf...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.2279

    authors: Goeritz I,Falk S,Stahl T,Schäfers C,Schlechtriem C

    更新日期:2013-09-01 00:00:00

  • Correlation of Tetrahymena and Pimephales toxicity: evaluation of 100 additional compounds.

    abstract::In the summary/recommendations for the Ecotoxicology Session of TestSmart--A Humane and Efficient Approach to Screening Information Data Sets (SIDS) Data Workshop, it was recommended that more population growth impairment data using Tetrahymena be generated and compared with available lethality data for the fathead mi...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:

    authors: Sinks GD,Schultz TW

    更新日期:2001-04-01 00:00:00

  • Persistent organic pollutants in coastal sediment off South China in relation to the importance of anthropogenic inputs.

    abstract::Surface sediments collected from the coastal region off South China were analyzed for persistent organic pollutants (POPs), including polybrominated diphenyl ethers (PBDEs), polycyclic aromatic hydrocarbons (PAHs), and organochlorine pesticides (OCPs). The concentrations of BDE-209, Σ(12)PBDE, Σ(15)PAH, Σ(7)PAH, and Σ...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.1807

    authors: Liu LY,Wang JZ,Qiu JW,Liang Y,Zeng EY

    更新日期:2012-06-01 00:00:00

  • Determination and multivariate statistical analysis of biochemical responses to environmental contaminants in feral freshwater fish Leuciscus cephalus, L.

    abstract::Modulations of 11 prospective biochemical markers of impacts of aquatic pollutants in liver tissue of chub (Leuciscus cephalus), caught at several sampling sites of a river with various pollution types and rates, were matched against analytical data of concentrations of organochlorine compounds, polycyclic aromatic hy...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:

    authors: Machala M,Dusek L,Hilscherová K,Kubínová R,Jurajda P,Neca J,Ulrich R,Gelnar M,Studnicková Z,Holoubek I

    更新日期:2001-05-01 00:00:00

  • Application of statistical experimental design and multivariate data analysis for evaluation of mixtures using cytochrome P4501A induction.

    abstract::Cytochrome P4501A (CYP1A) induction was evaluated in the rat hepatoma cell line H4IIE as a biomarker of exposure to organic compounds. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazoliumbromide assay was performed to assess the viability of cells exposed to environmentally relevant concentrations of cadmium. Cad...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1897/07-187

    authors: Jensen MH,Krøkje A

    更新日期:2008-08-01 00:00:00

  • Genetic impoverishment in laboratory cultures of the test organism Chironomus riparius.

    abstract::Genetic diversity among laboratory and field populations of Chironomus riparius was investigated using microsatellite DNA analysis. Individuals of midge cultures reared in 10 different laboratories showed a clear reduction in the number of alleles per locus and in the level of heterozygosity compared to two natural po...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1897/06-349r.1

    authors: Nowak C,Vogt C,Diogo JB,Schwenk K

    更新日期:2007-05-01 00:00:00

  • Accumulation and distribution of polychlorinated dibenzo-p-dioxin, dibenzofuran, and polychlorinated biphenyl congeners in Atlantic salmon (Salmo salar).

    abstract::Adult Atlantic salmon (Salmo salar) were fed on four diets containing polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) for 30 weeks. Lipid-normalized concentrations showed that all congeners were equally partitioned between whole-fish and fillet sam...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1897/03-367

    authors: Isosaari P,Kiviranta H,Lie O,Lundebye AK,Ritchie G,Vartiainen T

    更新日期:2004-07-01 00:00:00

  • The Effects of Soil Organic Carbon Content on Plant Uptake of Soil Perfluoro Alkyl Acids (PFAAs) and the Potential Regulatory Implications.

    abstract::Perfluoro alkyl acids (PFAAs) are known to bioconcentrate in plants grown in contaminated soils; the potential risk from consuming these plants is currently less understood. We determined that the current daily reference doses (RfDs) of the US Environmental Protection Agency (USEPA) could be met by consuming a single ...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.4786

    authors: Lasee S,Subbiah S,Deb S,Karnjanapiboonwong A,Payton P,Anderson TA

    更新日期:2020-05-30 00:00:00

  • Different behavior of tetracyclines and sulfonamides in sandy soils after repeated fertilization with liquid manure.

    abstract::Recently we showed that tetracyclines tend to persist and may accumulate in sandy soils after repeated fertilizations with liquid manure. We continued these field investigations from 2001 to 2003 and observed no further accumulation of tetracyclines in soil, but found that the average tetracycline concentration remain...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1897/04-182r.1

    authors: Hamscher G,Pawelzick HT,Höper H,Nau H

    更新日期:2005-04-01 00:00:00

  • Development and application of a novel method for high-throughput determination of PCDD/Fs and PCBs in sediments.

    abstract::A selective pressurized liquid extraction technique was developed for the simultaneous extraction of polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (dl-PCBs) from contaminated sediments. The final method incorporated cleanup adsorbents (Florisil, alumina, and silica...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.2579

    authors: Aguilar L,Williams ES,Brooks BW,Usenko S

    更新日期:2014-07-01 00:00:00

  • Assessment of potential immunotoxic effects caused by cypermethrin, fluoxetine, and thiabendazole using heat shock protein 70 and interleukin-1β mRNA expression in the anuran Xenopus laevis.

    abstract::The current study describes the effect of cypermethrin, fluoxetine, and thiabendazole, at environmentally relevant concentrations, on the expression of heat shock protein 70 (HSP70) and interleukin 1β (IL-1β), using Xenopus laevis larvae as animal model. Cytokines and interleukins are considered good predictors of the...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.313

    authors: Martini F,Fernández C,Segundo LS,Tarazona JV,Pablos MV

    更新日期:2010-11-01 00:00:00

  • Validation of a new standardized test method for the freshwater amphipod Hyalella azteca: Determining the chronic effects of silver in sediment.

    abstract::Environment Canada has developed a new 42-d sediment toxicity test method that includes a reproduction test endpoint with the freshwater amphipod Hyalella azteca. Because of concerns that existing standard methodologies, whereby adults are transferred to a water-only exposure before release of their first brood at day...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.3453

    authors: Taylor LN,Novak L,Rendas M,Antunes PM,Scroggins RP

    更新日期:2016-10-01 00:00:00

  • Comparative analysis of estrogenic activity in sewage treatment plant effluents involving three in vitro assays and chemical analysis of steroids.

    abstract::In this study, we assessed and compared the suitability of three in vitro screening tools for the measurement of estrogenic activity in sewage treatment plant effluents (STPEs). These assays were the yeast estrogen screen (YES), production of zona radiata proteins (ZRPs) in trout hepatocytes, and the induction of repo...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1897/03-286

    authors: Rutishauser BV,Pesonen M,Escher BI,Ackermann GE,Aerni HR,Suter MJ,Eggen RI

    更新日期:2004-04-01 00:00:00

  • Zinc toxicity to the mottled sculpin (Cottus bairdi) in high-hardness water.

    abstract::The median 96-h lethal zinc concentration (LC50) was 439 microg Zn/L (hardness of 154 mg/L as CaCO3) for feral mottled sculpin (Cottus bairdi), decreasing to a median incipient lethal level of 266 microg Zn/L after 13 d. The 30-d chronic value was 255 microg Zn/L. The acute toxicity-hardness (ln-ln) slope of 1.022 exc...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1897/04-235r.1

    authors: Brinkman S,Woodling J

    更新日期:2005-06-01 00:00:00

  • Predicted and observed therapeutic dose exceedances of ionizable pharmaceuticals in fish plasma from urban coastal systems.

    abstract::Instream flows of the rapidly urbanizing watersheds and estuaries of the Gulf of Mexico in Texas (USA) are increasingly dominated by reclaimed waters. Though ionizable pharmaceuticals have received increasing attention in freshwaters, many research questions remain unanswered, particularly in tidally influenced urban ...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.3236

    authors: Scott WC,Du B,Haddad SP,Breed CS,Saari GN,Kelly M,Broach L,Chambliss CK,Brooks BW

    更新日期:2016-04-01 00:00:00

  • Influence of N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid pH buffer on the biological response of marine algae.

    abstract::The N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid (HEPES) is extensively used as pH buffer in culture media for testing chemicals. However, this study demonstrates that 0.01 M HEPES significantly reduces the rate of Cu, Pb, and Cd binding to Porphyra spp. and Enteromorpha spp. marine macroalgae. The HEPES also d...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:

    authors: Vasconcelos MT,Leal MF

    更新日期:2002-02-01 00:00:00

  • Simultaneous analysis of multiclass contaminants of emerging concern in sediments by liquid chromatography with tandem quadrupole mass spectrometry.

    abstract::A quick, easy, cheap, effective, rugged, and safe (QuEChERS)-based extraction and simultaneous dispersive solid-phase extraction (dSPE) clean-up method was developed for contaminants of emerging concern (CECs) in sediment samples. Hydration with a phosphate buffer (pH 2.0) and salting out with NaCl and MgSO4 facilitat...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.4450

    authors: Rashid A,Wang Y,Li Y,Yu CP,Sun Q

    更新日期:2019-07-01 00:00:00

  • Evaluation of acute copper toxicity to juvenile freshwater mussels (fatmucket, Lampsilis siliquoidea) in natural and reconstituted waters.

    abstract::The influence of dissolved organic carbon (DOC) and water composition on the toxicity of copper to juvenile freshwater mussels (fatmucket, Lampsilis siliquoidea) were evaluated in natural and reconstituted waters. Acute 96-h copper toxicity tests werec onducted at four nominal DOC concentrations (0, 2.5, 5, and 10 mg/...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1897/08-655.1

    authors: Wang N,Mebane CA,Kunz JL,Ingersoll CG,May TW,Arnold WR,Santore RC,Augspurger T,Dwyer J,Barnhart MC

    更新日期:2009-11-01 00:00:00

  • Bioaccumulation and effects of dietary exposure to the alternative flame retardant, bis(2-ethylhexyl) tetrabromophthalate (TBPH), in the Atlantic killifish, Fundulus heteroclitus.

    abstract::Bis(2-ethylhexyl) tetrabromophthalate (TBPH), a high production volume flame retardant chemical used as a replacement for banned flame retardants, has been detected in media and human and wildlife tissues globally. We describe bioaccumulation and biological effects from dietary exposure of TBPH to an estuarine fish, A...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.4180

    authors: Nacci D,Clark B,La Guardia MJ,Miller K,Champlin D,Kirby I,Bertrand A,Jayaraman S

    更新日期:2018-09-01 00:00:00

  • Automated method for determination of dissolved organic carbon-water distribution constants of structurally diverse pollutants using pre-equilibrium solid-phase microextraction.

    abstract::Dissolved organic carbon (DOC) plays a key role in determining the environmental fate of semivolatile organic environmental contaminants. The goal of the present study was to develop a method using commercially available hardware to rapidly characterize the sorption properties of DOC in water samples. The resulting me...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.2805

    authors: Ripszam M,Haglund P

    更新日期:2015-02-01 00:00:00

  • Population and life-stage-specific effects of two herbicide formulations on the aquatic development of European common frogs (Rana temporaria).

    abstract::Environmental contamination is suggested to contribute to amphibian population declines. However, the effects of a contaminant on a particular amphibian species can differ among populations. The authors investigated the toxic effects of 2 herbicide formulations on different populations and on representative developmen...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.3525

    authors: Wagner N,Veith M,Lötters S,Viertel B

    更新日期:2017-01-01 00:00:00

  • The common ecotoxicology laboratory strain of Hyalella azteca is genetically distinct from most wild strains sampled in eastern North America.

    abstract::The amphipod Hyalella azteca is commonly used as a model for determining safe concentrations of contaminants in freshwaters. The authors sequenced the mitochondrial cytochrome c oxidase subunit I (COI) gene for representatives of 38 populations of this species complex from US and Canadian toxicology research laborator...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.2355

    authors: Major K,Soucek DJ,Giordano R,Wetzel MJ,Soto-Adames F

    更新日期:2013-11-01 00:00:00

  • Identifying the causes of sediment-associated toxicity in urban waterways in South China: incorporating bioavailabillity-based measurements into whole-sediment toxicity identification evaluation.

    abstract::Sediments in urban waterways of Guangzhou, China, were contaminated by a variety of chemicals and showed prevalent toxicity to benthic organisms. A combination of whole-sediment toxicity identification evaluation (TIE) and bioavailability-based extraction was used to identify the causes of sediment toxicity. Of the 6 ...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.2970

    authors: Yi X,Li H,Ma P,You J

    更新日期:2015-08-01 00:00:00

  • An in situ assay with the microalga Phaeodactylum tricornutum for sediment-overlying water toxicity evaluations in estuaries.

    abstract::Given the urgent need for ecologically relevant toxicity tools specific to estuarine systems, the main goal of the present study was to develop and evaluate the potential of an in situ algal assay for estuarine sediment-overlying water toxicity evaluations using the microalga Phaeodactylum tricornutum immobilized in a...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1897/05-266r.1

    authors: Moreira SM,Guilhermino L,Ribeiro R

    更新日期:2006-09-01 00:00:00

  • Characterization of salinity-enhanced toxicity of aldicarb to Japanese medaka: sexual and developmental differences.

    abstract::The effects of salinity, gender, and development on the acute toxicity of aldicarb were examined in the euryhaline fish, Japanese medaka (Oryzias latipes). The 96-h median lethal concentrations (LC50s) at 1.5 parts per thousand (per thousand) salinity were not significantly different between adults and juveniles but l...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:

    authors: El-Alfy AT,Grisle S,Schlenk D

    更新日期:2001-09-01 00:00:00

  • Polychlorinated biphenyl profiles in ringed seals (Pusa Hispida) reveal historical contamination by a military radar station in Labrador, Canada.

    abstract::Significant amounts of soil contaminated with polychlorinated biphenyls (PCBs) were discovered at a military radar station in Saglek Bay, Labrador, Canada, in 1996. Subsequent work showed elevated PCB concentrations in local marine sediments, in the benthic-associated food web, and in some ringed seals (Pusa hispida)....

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.2468

    authors: Brown TM,Fisk AT,Helbing CC,Reimer KJ

    更新日期:2014-03-01 00:00:00

  • Lethal and behavioral impacts of diesel and fuel oil on the Antarctic amphipod Paramoera walkeri.

    abstract::Toxicity testing with Antarctic species is required for risk assessment of fuel spills in Antarctic coastal waters. The lethal and sublethal (movement behavior) sensitivities of adults and juveniles of the Antarctic amphipod Paramoera walkeri to the water accommodated fractions (WAFs) of 3 fuels were estimated in exte...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.3778

    authors: Brown KE,King CK,Harrison PL

    更新日期:2017-09-01 00:00:00

  • Abiotic dealkylation and hydrolysis of atrazine by birnessite.

    abstract::Atrazine (2-chloro-4-ethylamino-6-isopropylamino-s-triazine) and its degradation products are important contaminants of world water systems and have effects on aquatic life. These effects are modulated by the degradation of atrazine, which depends, in part, on its reactivity with soil minerals. We have studied the deg...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1897/04-248r.1

    authors: Shin JY,Cheney MA

    更新日期:2005-06-01 00:00:00

  • Implications of global climate change for the assessment and management of human health risks of chemicals in the natural environment.

    abstract::Global climate change (GCC) is likely to alter the degree of human exposure to pollutants and the response of human populations to these exposures, meaning that risks of pollutants could change in the future. The present study, therefore, explores how GCC might affect the different steps in the pathway from a chemical...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.2046

    authors: Balbus JM,Boxall AB,Fenske RA,McKone TE,Zeise L

    更新日期:2013-01-01 00:00:00