Predicted and observed therapeutic dose exceedances of ionizable pharmaceuticals in fish plasma from urban coastal systems.

Abstract:

:Instream flows of the rapidly urbanizing watersheds and estuaries of the Gulf of Mexico in Texas (USA) are increasingly dominated by reclaimed waters. Though ionizable pharmaceuticals have received increasing attention in freshwaters, many research questions remain unanswered, particularly in tidally influenced urban coastal systems, which experience significant spatiotemporal variability in pH that influences bioavailability and bioaccumulation. The authors coupled fish plasma modeling of therapeutic hazard values with field monitoring of water chemistry variability and pharmaceutical occurrence to examine whether therapeutic hazards to fish existed within these urban coastal ecosystems and whether therapeutic hazards differed within and among coastal locations and seasons. Spatial and temporal fluctuations in pH within study sites altered the probability of encountering pharmaceutical hazards to fish. Significant water quality differences were consistently observed among traditional parameters and pharmaceuticals collected from surface and bottom waters, which are rarely sampled during routine surface water quality assessments. The authors then compared modeling predictions of fish plasma concentrations of pharmaceuticals to measured plasma levels from various field-collected fish species. Diphenhydramine and diltiazem were observed in plasma of multiple species, and diltiazem exceeded human therapeutic doses in largemouth bass, catfish, and mullet inhabiting these urban estuaries. Though the present study only examined a small number of target analytes, which represent a microcosm of the exposome of these fish, coastal systems are anticipated to be more strongly influenced by continued urbanization, altered instream flows, and population growth in the future. Unfortunately, aquatic toxicology information for diltiazem and many other pharmaceuticals is not available for marine and estuarine organisms, but such field observations suggest that potential adverse outcomes should be examined.

journal_name

Environ Toxicol Chem

authors

Scott WC,Du B,Haddad SP,Breed CS,Saari GN,Kelly M,Broach L,Chambliss CK,Brooks BW

doi

10.1002/etc.3236

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

983-95

issue

4

eissn

0730-7268

issn

1552-8618

journal_volume

35

pub_type

杂志文章
  • Validation of a new standardized test method for the freshwater amphipod Hyalella azteca: Determining the chronic effects of silver in sediment.

    abstract::Environment Canada has developed a new 42-d sediment toxicity test method that includes a reproduction test endpoint with the freshwater amphipod Hyalella azteca. Because of concerns that existing standard methodologies, whereby adults are transferred to a water-only exposure before release of their first brood at day...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.3453

    authors: Taylor LN,Novak L,Rendas M,Antunes PM,Scroggins RP

    更新日期:2016-10-01 00:00:00

  • Environmental cadmium induces histopathological changes in kidneys of roe deer.

    abstract::Kidney samples of 224 roe deer (113 males, 111 females) aged three months to approximately nine years were collected in eastern Austria. Cadmium contents were examined and histological examinations were performed considering 11 different pathomorphological parameters. Cadmium burden was relatively high (range: 0.010-2...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:

    authors: Beiglböck C,Steineck T,Tataruch F,Ruf T

    更新日期:2002-09-01 00:00:00

  • Metal contaminant accumulation in the hive: Consequences for whole-colony health and brood production in the honey bee (Apis mellifera L.).

    abstract::Metal pollution has been increasing rapidly over the past century, and at the same time, the human population has continued to rise and produce contaminants that may negatively impact pollinators. Honey bees (Apis mellifera L.) forage over large areas and can collect contaminants from the environment. The primary obje...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.3273

    authors: Hladun KR,Di N,Liu TX,Trumble JT

    更新日期:2016-02-01 00:00:00

  • Using biofilms for monitoring metal contamination in lotic ecosystems: The protective effects of hardness and pH on metal bioaccumulation.

    abstract::Biofilms can make good bioindicators and biomarkers, offering a convenient tool to monitor metal contamination in streams that results from mine tailing sites. Biofilm metal content (Cu, Zn, Cd, Pb) as well as diatom diversity and the presence of teratologies (diatom abnormalities) were determined for biofilms from ri...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.3292

    authors: Leguay S,Lavoie I,Levy JL,Fortin C

    更新日期:2016-06-01 00:00:00

  • Influences of metal concentration in phytoplankton and seawater on metal assimilation and elimination in marine copepods.

    abstract::Radiotracer experiments were conducted to examine the influence of the concentration of Cd, Se, and Zn in ingested phytoplankton (dinoflagellate Prorocentrum minimum and diatom Thalassiosira weissflogii) and in ambient seawater on metal assimilation and elimination efficiencies of three marine copepods, Acartia spinic...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:

    authors: Xu Y,Wang WX,Hsieh DP

    更新日期:2001-05-01 00:00:00

  • Seasonal study on the Cd, Se, and Zn uptake by natural coastal phytoplankton assemblages.

    abstract::We conducted a seasonal study of the uptake of Cd, Se(IV), and Zn by natural phytoplankton assemblages collected from two locations in Hong Kong coastal waters. Marine phytoplankton in Port Shelter was dominated by diatoms and cyanobacteria, while phytoplankton in Tolo Harbour was dominated by dinoflagellates. The nat...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1897/04-125r.1

    authors: Wang WX,Dei RC,Hong H

    更新日期:2005-01-01 00:00:00

  • Can sediment total organic carbon and grain size be used to diagnose organic enrichment in estuaries?

    abstract::Eutrophication (i.e., nutrient enrichment, organic enrichment, and oxygen depletion) is one of the most common sources of impairment in Clean Water Act 303(d)-listed waters in the United States. Although eutrophication can eventually cause adverse effects to the benthos, it may be difficult to diagnose. Sediment organ...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.414

    authors: Pelletier MC,Campbell DE,Ho KT,Burgess RM,Audette CT,Detenbeck NE

    更新日期:2011-03-01 00:00:00

  • Gill lesions and death of bluegill in an acid mine drainage mixing zone.

    abstract::The toxicity of an acid mine drainage (AMD) mixing zone was investigated by placing bluegill (Lepomis macrochirus) at the confluence of a stream contaminated by AMD and a stream having neutral pH. A mixing channel receiving water from both streams was assembled in the field, during July and October 1996, to determine ...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:

    authors: Henry TB,Irwin ER,Grizzle JM,Brumbaugh WG,Wildhaber ML

    更新日期:2001-06-01 00:00:00

  • A nonlethal microsampling technique to monitor the effects of mercury on wild bird eggs.

    abstract::Methylmercury is the predominant chemical form of mercury reported in the eggs of wild birds, and the embryo is the most sensitive life stage to methylmercury toxicity. Protective guidelines have been based mainly on captive-breeding studies with chickens (Gallus gallus), mallards (Anas platyrhynchos), and ring-necked...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1897/08-316.1

    authors: Stebbins KR,Klimstra JD,Eagles-Smith CA,Ackerman JT,Heinz GH

    更新日期:2009-03-01 00:00:00

  • Uptake and elimination of ionizable organic chemicals at fish gills: II. Observed and predicted effects of ph, alkalinity, and chemical properties.

    abstract::Effects of exposure-water pH on chemical uptake at rainbow trout (Oncorhynchus mykiss) gills were investigated for nine weakly acidic, chlorinated phenols with different ionization constants and hydrophobicities and for a moderately hydrophobic, nonionizable reference chemical (1,2,4-trichlorobenzene). Uptake rates fo...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1897/05-359r.1

    authors: Erickson RJ,McKim JM,Lien GJ,Hoffman AD,Batterman SL

    更新日期:2006-06-01 00:00:00

  • Effects of ethynylestradiol on the reproductive physiology in zebrafish (Danio rerio): time dependency and reversibility.

    abstract::Environmental pollution with natural or synthetic estrogens may pose a serious threat to reproduction of wildlife species. This study describes the effects of 17-alpha-ethynylestradiol (EE2) on fish reproductive organs in a laboratory model. Adult zebrafish were semistatically exposed to nominal concentrations of 0, 1...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:

    authors: Van den Belt K,Wester PW,van der Ven LT,Verheyen R,Witters H

    更新日期:2002-04-01 00:00:00

  • Source Identification and Health Risk Assessment of Polycyclic Aromatic Hydrocarbon-Enriched PM2.5 in Tangshan, China.

    abstract::Tangshan city in Hebei Province is one of the most heavily polluted cities in China, with substantial industrial emissions. The development of effective air pollution emission reduction policies requires knowledge of the sources and health risks of polycyclic aromatic hydrocarbon (PAH)-enriched fine particulate matter...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.4618

    authors: Zhang L,Xu H,Fang B,Wang H,Yang Z,Yang W,Hao Y,Wang X,Wang Q,Wang M

    更新日期:2020-02-01 00:00:00

  • Inhibition of microbial metabolism in anaerobic lagoons by selected sulfonamides, tetracyclines, lincomycin, and tylosin tartrate.

    abstract::Antibiotics are used to maintain healthy livestock and to promote weight gain in concentrated animal feed operations. Antibiotics rarely are metabolized completely by livestock and, thus, are often present in livestock waste and in waste-treatment lagoons. The introduction of antibiotics into anaerobic lagoons commonl...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1897/04-093r.1

    authors: Loftin KA,Henny C,Adams CD,Surampali R,Mormile MR

    更新日期:2005-04-01 00:00:00

  • Influence of sorbate planarity on the magnitude of rapidly desorbing fractions of organic compounds in sediment.

    abstract::Organic compounds in sediments are known to distribute between rapid, slowly, and very slowly desorbing sites. This distribution is relevant to bioavailability and risk assessment of organic compounds in sediment. In this study, the fraction desorbing to Tenax in 6 h was measured for a range of organic compounds in se...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:

    authors: van Noort PC,Cornelissen G,ten HT,Belfoid A

    更新日期:2002-11-01 00:00:00

  • Fate of fluorotelomer acids in a soil-water microcosm.

    abstract::Fluorotelomer carboxylic acids (FTCAs) and the corresponding unsaturated acids (FTUCAs) are known intermediates in the biodegradation of industrially produced fluorotelomer alcohols (FTOHs) to environmentally persistent perfluorinated carboxylic acids (PFCAs). The FTCAs and FTUCAs are of concern for their toxicity, re...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.211

    authors: Myers AL,Mabury SA

    更新日期:2010-08-01 00:00:00

  • Chemical speciation and cellular deposition of lead in Sesbania drummondii.

    abstract::The internalized speciation of lead in roots and leaves of Sesbania drummondii, a lead hyperaccumulator, grown in lead nitrate solution was studied using x-ray absorption near-edge structure and extended x-ray absorption fine structure. Lead was predominantly present as lead acetate in both plant tissues. The other do...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1897/03-540

    authors: Sharma NC,Gardea-Torresdey JL,Parsons J,Sahi SV

    更新日期:2004-09-01 00:00:00

  • Gibbs free energies for dual Langmuir-like adsorption onto hard carbon materials in sediment and soils.

    abstract::Adsorption of organic compounds onto hard carbon constituents of soils and sediments may be described by a dual Langmuir-like equation for adsorption onto high-energy sites and low-energy sites. To describe quantitatively the sorbate-sorbent interactions on these high-energy sites and low-energy sites, Gibbs free ener...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1897/06-218r.1

    authors: van Noort PC

    更新日期:2006-12-01 00:00:00

  • Estimation of polychlorinated biphenyl fugacity ratios.

    abstract::On the quantitative comparison of solubilities or vapor pressures of homologous series, the variation in the effect of crystal structure on solid properties may substantially influence the outcome of the comparison. Usually, the effect of this variation is eliminated by comparing values of the liquid state. The ratio ...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1897/06-083r.1

    authors: Van Noort PC

    更新日期:2006-11-01 00:00:00

  • The effects of antidepressants appear to be rapid and at environmentally relevant concentrations.

    abstract::The effects of antidepressants on wildlife are currently raising some concern because of an increased number of publications indicating biological effects at environmentally relevant concentrations (<100 ng/L). These results have been met with some scepticism because of the higher concentrations required to detect eff...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章,评审

    doi:10.1002/etc.3087

    authors: Ford AT,Fong PP

    更新日期:2016-04-01 00:00:00

  • Potentiation of the vitellogenic response to 17alpha-ethinylestradiol by cortisol in the fathead minnow Pimephales promelas.

    abstract::The effects of elevated plasma cortisol levels on vitellogenin (VTG) induction were examined in the fathead minnow (Pimephales promelas) in an attempt to evaluate the potential influence of stress on this commonly used biomarker of estrogenicity. Two separate experiments were conducted in which fish plasma cortisol wa...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1897/04-309r.1

    authors: Brodeur JC,Woodburn KB,Klecka GM

    更新日期:2005-05-01 00:00:00

  • Ecotoxicity of Nitrogen, Sulfur, or Oxygen Heterocycles and Short-Chained Alkyl Phenols Commonly Detected in Contaminated Groundwater.

    abstract::Nitrogen, sulfur, or oxygen heterocyclic aromatic hydrocarbons (NSO-HETs) and short-chained alkyl phenols (SCAPs) are commonly detected in groundwater at contaminated sites and in the surrounding environment. It is now scientific consensus that these chemicals pose a risk to human and ecosystem health. However, toxici...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.4423

    authors: Brinkmann M,Schneider AL,Bluhm K,Schiwy S,Lehmann G,Deutschmann B,Müller A,Tiehm A,Hollert H

    更新日期:2019-06-01 00:00:00

  • Application of toxicity identification evaluation procedures for characterizing produced water using the tropical mysid, Metamysidopsis insularis.

    abstract::Toxicity identification evaluations (TIEs) were performed on seven produced water (PW) effluents from inland discharge facilities operated in Trinidad and Tobago, a Caribbean tropical country with one of the oldest commercial oil industries in the world. The research was performed to determine the presence and magnitu...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1897/02-530

    authors: Elias-Samlalsingh N,Agard JB

    更新日期:2004-05-01 00:00:00

  • Effects of spray drift of glyphosate on nontarget terrestrial plants-A critical review.

    abstract::Glyphosate is a widely used broad-spectrum postemergent herbicide used for weed control in both agricultural and nonagricultural settings. Spray drift of glyphosate can pose a risk to nontarget terrestrial plants and plant communities outside the intended area of application, but the lack of a well-established predict...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/etc.3925

    authors: Cederlund H

    更新日期:2017-11-01 00:00:00

  • Polycyclic aromatic hydrocarbons and black carbon in sediments of a remote alpine lake (Lake Planina, northwest Slovenia).

    abstract::Polycyclic aromatic hydrocarbons (PAH) and black carbon (BC) were measured in alpine Lake Planina (Slovenia) sediment. Lake Planina is a remote mountain lake with almost no direct anthropogenic influence. Long-distance atmospheric deposition is a major pathway for the loading of contaminants to the sediment. The PAH w...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:

    authors: Muri G,Wakeham SG,Faganeli J

    更新日期:2003-05-01 00:00:00

  • The fungicide propiconazole interferes with embryonic development of the crustacean Daphnia magna.

    abstract::Propiconazole is a fungicide used in a variety of agricultural applications. Preliminary studies had suggested that embryos of the crustacean Daphnia magna are particularly susceptible to the toxicity of this chemical. The goals of the present study were to define endpoints of daphnid embryonic development that could ...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1897/1551-5028(2001)020<0502:tfpiwe>2.0.co;2

    authors: Kast-Hutcheson K,Rider CV,LeBlanc GA

    更新日期:2001-03-01 00:00:00

  • A Comparison of the chemical sensitivities between in vitro and in vivo propagated juvenile freshwater mussels: Implications for standard toxicity testing.

    abstract::Unionid mussels are ecologically important and are globally imperiled. Toxicants contribute to mussel declines, and toxicity tests using juvenile mussels-a sensitive life stage-are valuable in determining thresholds used to set water quality criteria. In vitro culture methods provide an efficient way to propagate juve...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.4270

    authors: Popp A,Cope WG,McGregor MA,Kwak TJ,Augspurger T,Levine JF,Koch L

    更新日期:2018-12-01 00:00:00

  • Determining octanol-water partition coefficients for extremely hydrophobic chemicals by combining "slow stirring" and solid-phase microextraction.

    abstract::Octanol-water partition coefficients (KOW ) are widely used in fate and effects modeling of chemicals. Still, high-quality experimental KOW data are scarce, in particular for very hydrophobic chemicals. This hampers reliable assessments of several fate and effect parameters and the development and validation of new mo...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.3300

    authors: Jonker MT

    更新日期:2016-06-01 00:00:00

  • Thiamethoxam honey bee colony feeding study: Linking effects at the level of the individual to those at the colony level.

    abstract::Neonicotinoid insecticides have been used globally on a wide range of crops through seed treatment as well as soil and foliar applications and have been increasingly studied in relation to the potential risk to bees because of their detection in pollen and nectar of bee-attractive crops. The present article reports th...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.4018

    authors: Overmyer J,Feken M,Ruddle N,Bocksch S,Hill M,Thompson H

    更新日期:2018-03-01 00:00:00

  • Contaminant residues and declines of the Cascades frog (Rana cascadae) in the California Cascades, USA.

    abstract::Populations of Cascades frogs (Rana cascadae) have declined precipitously in the Mount Lassen area, but remain abundant in the other half of their California range in the Klamath Mountains. To evaluate the role of contaminants in Cascade frog declines, we sampled sediment and frog tadpole tissue at 31 sites where Casc...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章

    doi:10.1002/etc.1902

    authors: Davidson C,Stanley K,Simonich SM

    更新日期:2012-08-01 00:00:00

  • Interactions between mercury and phytoplankton: speciation, bioavailability, and internal handling.

    abstract::The present review describes and discusses key interactions between mercury (Hg) and phytoplankton to highlight the role of phytoplankton in the biogeochemical cycle of Hg and to understand direct or indirect Hg effects on phytoplankton. Phytoplankton are exposed to various Hg species in surface waters. Through Hg upt...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章,评审

    doi:10.1002/etc.2424

    authors: Le Faucheur S,Campbell PG,Fortin C,Slaveykova VI

    更新日期:2014-06-01 00:00:00