Abstract:
:Bis(2-ethylhexyl) tetrabromophthalate (TBPH), a high production volume flame retardant chemical used as a replacement for banned flame retardants, has been detected in media and human and wildlife tissues globally. We describe bioaccumulation and biological effects from dietary exposure of TBPH to an estuarine fish, Atlantic killifish, Fundulus heteroclitus. Briefly, adult fish were fed carrier control or chemically amended diets for 28 d, followed by 14 d of control diet feeding. Diets were amended with TBPH (TBPH_LO diet, 139 μg/g dry wt, or TBPH_HI diet, 4360 μg/g dry wt) or a polychlorinated biphenyl congener (PCB153 diet, 13 μg/g dry wt), which was included as a positive control for bioaccumulation. Although bioaccumulation of either chemical correlated with fish size, only a small proportion of the TBPH offered (<0.5% total TBPH) had bioaccumulated into TBPH-treated fish by 28 d. In contrast, 24.5% of the PCB153 offered was accounted for in 28-d PCB-treated fish. Although 28-d bioaccumulated concentrations of TBPH differed by sex and treatment, sexes did not differ in their rates of TBPH bioaccumulation, and the time to achieve 50% of 28 d concentration (T1/2 ) was estimated to be 13 d. Depuration rates of TBPH did not differ by sex or treatment, and the time after exposure to achieve T1/2 was estimated to be 22 d. Independent of treatment, male fish grew faster than female fish, but for both sexes reproductive condition (gonadal somatic index) declined unexpectedly over the experimental period. Across treatments, only the TBPH_LO treatment affected growth, reducing male but increasing female growth rates by small amounts relative to respective controls. In summary, our study used very high concentrations of dietary TBPH to contaminate fish tissues above the highest levels reported to date in wild biota, yet we observed few adverse biological effects. Environ Toxicol Chem 2018;37:2350-2360. © 2018 SETAC. This article is a US government work and, as such, is in the public domain in the United States of America.
journal_name
Environ Toxicol Chemjournal_title
Environmental toxicology and chemistryauthors
Nacci D,Clark B,La Guardia MJ,Miller K,Champlin D,Kirby I,Bertrand A,Jayaraman Sdoi
10.1002/etc.4180subject
Has Abstractpub_date
2018-09-01 00:00:00pages
2350-2360issue
9eissn
0730-7268issn
1552-8618journal_volume
37pub_type
杂志文章abstract::Concentrations of arsenic, cadmium, copper, lead, and nickel were measured in soils, house mice (Mus musculus), and the main food items of this omnivorous mouse to examine the occurrence of these metals in selected components of a seasonal wetland. Soil concentrations of copper, lead, and (in some areas) nickel were e...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/1551-5028(2001)020<2617:bomipa>2.0.co;2
更新日期:2001-11-01 00:00:00
abstract::A dike failure at the Tennessee Valley Authority Kingston Fossil Plant in East Tennessee, United States, in December 2008, released approximately 4.1 million m(3) of coal ash into the Emory River. From 2009 through 2012, samples of mayfly nymphs (Hexagenia bilineata) were collected each spring from sites in the Emory,...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.3253
更新日期:2016-05-01 00:00:00
abstract::Octanol-water partition coefficients (KOW ) are widely used in fate and effects modeling of chemicals. Still, high-quality experimental KOW data are scarce, in particular for very hydrophobic chemicals. This hampers reliable assessments of several fate and effect parameters and the development and validation of new mo...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.3300
更新日期:2016-06-01 00:00:00
abstract::An assessment of biodegradability was carried out for fragrance substances containing quaternary carbons by using data obtained from Organisation for Economic Co-operation and Development (OECD) 301F screening tests for ready biodegradation and from Biowin and Catalogic prediction models. Despite an expected challengi...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.2523
更新日期:2014-05-01 00:00:00
abstract::The Athabasca River basin, located in Alberta, Canada, covers 157, 000 km(2) and holds significant cultural and economic importance. Recent research assessed changes in several water quality and quantity parameters that have changed both spatially (along the river continuum) and temporally (pre-development and present...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.2081
更新日期:2013-03-01 00:00:00
abstract::Sediments in urban waterways of Guangzhou, China, were contaminated by a variety of chemicals and showed prevalent toxicity to benthic organisms. A combination of whole-sediment toxicity identification evaluation (TIE) and bioavailability-based extraction was used to identify the causes of sediment toxicity. Of the 6 ...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.2970
更新日期:2015-08-01 00:00:00
abstract::Populations of Cascades frogs (Rana cascadae) have declined precipitously in the Mount Lassen area, but remain abundant in the other half of their California range in the Klamath Mountains. To evaluate the role of contaminants in Cascade frog declines, we sampled sediment and frog tadpole tissue at 31 sites where Casc...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.1902
更新日期:2012-08-01 00:00:00
abstract::Deposit-feeders may be important in facilitating the removal of organic contaminants from bulk sediment. The relationship between uptake route (water vs sediment), depuration and toxicity was investigated in the deposit-feeding polychaete Capitella species I. Individual worms were exposed either to dissolved (i.e., < ...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/02-271
更新日期:2003-10-01 00:00:00
abstract::Heavy metals can represent a threat to the health of aquatic ecosystems. Unlike organic chemicals, heavy metals cannot be eliminated by natural processes such as their degradation into less toxic compounds, and this creates unique challenges for their remediation from soil, water, and air. Phytoremediation, defined as...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章,评审
doi:10.1002/etc.4909
更新日期:2021-01-01 00:00:00
abstract::Environmental contaminants can interfere with hormonal regulation in both vertebrates and invertebrates, and these contaminants may disrupt the endocrine system of human and other organisms. Evidence is growing that contaminants may be partly responsible for the observed increase of disease in marine organisms by adve...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/08-642.1
更新日期:2009-08-01 00:00:00
abstract::Waterborne Cu effects on the transcription of genes encoding ion-transporting proteins and the activities of these proteins were evaluated in gills of the blue crab Callinectes sapidus acclimated to diluted (2‰) and full (30‰) seawater. Crabs were exposed (96 h) to an environmentally relevant concentration of dissolve...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.370
更新日期:2011-01-01 00:00:00
abstract::Acute and chronic toxicity of eight agricultural adjuvants (Bond, Kinetic, Plyac, R-11, Silwet L-77, Sylgard 309, X-77, and WaterMaxx) to Daphnia pulex were evaluated with 48-h acute lethal concentration estimates (LC50) and a 10-d population growth-rate measurement, the instantaneous rate of increase (r1). Based on L...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/02-504
更新日期:2003-12-01 00:00:00
abstract::There is growing concern over the effects of increased salinization on freshwater organisms, which are largely unknown for unionid mussels. Adult and larval Elliptio complanata were exposed to low-level salt concentrations to determine the effects on mussel survival, physiology, and reproduction. Adults were exposed t...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.2381
更新日期:2013-12-01 00:00:00
abstract::A field monitoring campaign investigating the suitability of (Cd, Zn)-metallothionein concentrations (MTs) in different tissues of the gudgeon as a biomarker for metal contamination in the aquatic environment was conducted. Gudgeons were captured at 10 sampling sites on a river system in Flanders (Belgium). Nine sampl...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:
更新日期:2003-07-01 00:00:00
abstract::The toxicity and efficacy of a bacteria-based commercial bioremediation agent (CBA) was assessed through bioassays with juvenile inland silverside minnows, Menidia beryllina, and flask studies of oil degradation. Addition of the CBA to weathered Alaska, USA North Slope crude oil (ANS-521) prior to testing increased to...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::A Unit World approach has been used extensively to rank chemicals for their hazards and to understand differences in chemical behavior. Whereas the fate and effects of an organic chemical in a Unit World Model (UWM) analysis vary systematically according to one variable (fraction of organic carbon), and the chemicals ...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.606
更新日期:2011-09-01 00:00:00
abstract::The rising potential for the release of engineered nanoparticles (ENPs) into aquatic environments requires evaluation of risks to protect ecological health. The present review examines knowledge pertaining to the interactions of metal-based ENPs with aquatic higher plants, identifies information gaps, and raises consi...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章,评审
doi:10.1002/etc.3364
更新日期:2016-07-01 00:00:00
abstract::The present review describes and discusses key interactions between mercury (Hg) and phytoplankton to highlight the role of phytoplankton in the biogeochemical cycle of Hg and to understand direct or indirect Hg effects on phytoplankton. Phytoplankton are exposed to various Hg species in surface waters. Through Hg upt...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章,评审
doi:10.1002/etc.2424
更新日期:2014-06-01 00:00:00
abstract::The uptake and toxicity of 2 poly(methylmethacrylate)-based plastic nanoparticles (PNPs) with different surface chemistries (medium and hydrophobic) were assessed using aquatic organisms selected for their relevance based on the environmental behavior of the PNPs. Pure poly(methylmethacrylate) (medium; PMMA PNPs) and ...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.3076
更新日期:2016-07-01 00:00:00
abstract::The European Union System for the Evaluation of Substances (EUSES) is a computerized model system to facilitate and harmonize health and environmental risk assessment of previously notified and new substances. For calculation of regional background exposure, a multimedia distribution model is used. In the present stud...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/03-529
更新日期:2004-10-01 00:00:00
abstract::In the present study, microbial community responses to exposure to unweathered Macondo Well crude oil and conventional diesel in a sandy beach environment were determined. Biodegradation was assessed in mesocosm experiments with differing fuel amounts (2,000 and 4,000 mg/kg) and with or without inorganic nutrient amen...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.1770
更新日期:2012-05-01 00:00:00
abstract::Organophosphate and carbamate compounds are among the most widely used pesticides. Contamination of surface water by these compounds is of concern because of potential toxicity to aquatic organisms, especially those at lower trophic levels. In this study we evaluated the persistence of diazinon, chlorpyrifos, malathio...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/03-436
更新日期:2004-11-01 00:00:00
abstract::Few studies have investigated the potential reproductive effects of toxicants on Australian freshwater fish species. The present study uses the Australian rainbowfish (Melanotaenia fluviatilis) as a model for testing the potential effects of 17beta-estradiol. Groups of reproductively active rainbowfish were exposed to...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/06-603R.1
更新日期:2007-10-01 00:00:00
abstract::The present study considers the collection and use of ecotoxicity data for risk assessment with species sensitivity distributions (SSDs) of chemical pollution in surface water, which are used to quantify the likelihood that critical effect levels are exceeded. This fits the European Water Framework Directive, which su...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.4373
更新日期:2019-04-01 00:00:00
abstract::The lipid-lowering agents bezafibrate and clofibric acid, which occur at concentrations up to 3.1 and 1.6 microg/L, respectively, are among the most frequently found human pharmaceuticals in the aquatic environment. In contrast to knowledge about their environmental occurrence, little is known about their effects in t...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/09-087.1
更新日期:2009-12-01 00:00:00
abstract::Recent studies have indicated the potential for dietborne metals as an important exposure pathway for metal toxicity in freshwater organisms. We conducted a study in which freshwater cladocerans (Ceriodaphnia dubia) were fed green algae (either Pseudokirchneriella subcapitata or Chlorella vulgaris) that were grown in ...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/07-587.1
更新日期:2009-01-01 00:00:00
abstract::The present study investigated the effects of 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) on the thyroid and steroid-metabolizing system in Atlantic salmon (Salmo salar) parr. Fish were exposed to waterborne DDE and thyroxine (T4), both singly and in combination, for 5 d. Thyroid-stimulating hormone (TSHbeta), ...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/05-376r1.1
更新日期:2006-06-01 00:00:00
abstract::Adult African clawed frogs (Xenopus laevis) were collected from a corn-growing region (CGR) and a non-corn-growing region (NCGR) with different exposure profiles for atrazine and related triazines. Physical, chemical, and biological parameters from the catchment areas were also measured. Frogs were surveyed for possib...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/03-450
更新日期:2004-08-01 00:00:00
abstract::A modeling study was conducted to examine the distribution of concentrations of the antimicrobial triclosan (2,4,4'-trichloro-2'-hydroxydiphenyl ether) in rivers following discharge from wastewater treatment plants (WWTPs). Most uses of triclosan are disposed of down residential drains and ultimately reach WWTPs. A mo...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:
更新日期:2002-11-01 00:00:00
abstract::The results of the present study have demonstrated the utility of an estrogen receptor (ER) competitive ligand-binding assay, a hepatocyte vitellogenin (VTG) induction bioassay, and an ER reporter gene bioassay in characterizing the activity of model estrogen agonists (17beta-estradiol [E2], ethynylestradiol, and nony...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/05-686r.1
更新日期:2006-12-01 00:00:00