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Vacuolar myositis with expression of both MHC class I and class II antigens on skeletal muscle fibers.

Abstract：

:We describe here a 10-year-old patient with high levels of serum IgE and inflammatory myopathy whose muscle fibers exhibit excessive autophagy. Previous studies have demonstrated surface expression of class I MHC antigens on muscle fibers from patients with inflammatory myopathy. The muscle fibers of this patients showed marked expression of both class I and class II MHC antigens. The reaction products were demonstrated not only on sarcolemma but also in and around some vacuoles. Both CD4-positive and CD8-positive T-lymphocytes were noted in inflammatory exudates surrounding these fibers but B-lymphocytes were rare. We hypothesize that myocyte expression of both class I and class II antigens may play a role in the pathogenesis of this new type of inflammatory myopathy.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Higuchi I,Nerenberg M,Ijichi T,Fukunaga H,Arimura K,Usuki F,Kuriyama M,Osame M

doi

10.1016/0022-510x(91)90195-d

subject

Has Abstract

pub_date

1991-11-01 00:00:00

pages

60-6

issue

1

eissn

0022-510X

issn

1878-5883

pii

0022-510X(91)90195-D

journal_volume

106

pub_type

杂志文章

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