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Peripheral levels of angiotensins are associated with depressive symptoms in Parkinson's disease.

Abstract：

BACKGROUND:The pathogenesis of PD remains elusive. The renin-angiotensin-system (RAS) has recently been implicated in the degeneration of dopaminergic neurons. This study aimed to compare plasma levels of components of the RAS of individuals with PD with controls. We also investigated the association between these circulating markers and motor, depressive and cognitive parameters. METHODS:Thirty PD patients and twenty controls were subjected to clinical evaluation, including cognitive and depressive symptoms assessment. Plasma levels of Angiotensin (Ang) I, Ang II, Ang- (1-7), angiotensin-converting enzyme (ACE) and ACE2 were measured by Enzyme-Linked Immunosorbent Assay (ELISA). RESULTS:PD patients presented lower plasma levels of Ang I, Ang II and Ang- (1-7) than control individuals. Among PD patients, lower circulating levels of angiotensins were associated with increased severity of depressive symptoms. CONCLUSIONS:This is the first study showing that peripheral levels of RAS components are changed in PD and associated with depressive symptoms.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Rocha NP,Scalzo PL,Barbosa IG,de Campos-Carli SM,Tavares LD,de Souza MS,Christo PP,Reis HJ,Simões E Silva AC,Teixeira AL

doi

10.1016/j.jns.2016.07.031

subject

Has Abstract

pub_date

2016-09-15 00:00:00

pages

235-9

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(16)30446-4

journal_volume

368

pub_type

杂志文章

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