Abstract:
:Peptides prepared from the amino termini of pro alpha 1(I) and pro alpha 1(III) collagen chains inhibit the production of pro alpha 1(I) and pro alpha 2 by rat calvaria rna in a reticulocyte cell-free system. The synthesis of other proteins was not altered, suggesting a specific effect on collagen production. Various peptides from the helical region of the alpha 1(I) chain did not alter translation. These studies, taken together with earlier studies showing inhibition of collagen synthesis by cells in culture receiving the amino-terminal peptides, are consistent with a regulatory function in collagen synthesis for the amino-terminal peptides from procollagen.
journal_name
Biochemistryjournal_title
Biochemistryauthors
Paglia L,Wilczek J,de Leon LD,Martin GR,Hörlein D,Müller Pdoi
10.1021/bi00589a034subject
Has Abstractpub_date
1979-10-30 00:00:00pages
5030-4issue
22eissn
0006-2960issn
1520-4995journal_volume
18pub_type
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