The vitamin D receptor.

Abstract:

:The vitamin D endocrine system is known for its essential role in calcium homeostasis and bone metabolism, and induces cell differentiation, inhibits cell growth, controls other hormonal systems, and modulates the immune response. Vitamin D(3) is a prohormone that is taken up by diet or synthesized in ultraviolet radiation-exposed skin and metabolically converted to the active metabolite, 1alpha,25-dihydroxyvitamin D(3). This nuclear hormone binds with high affinity the nuclear receptor vitamin D receptor. More than 3000 synthetic analogs of 1alpha,25(OH)(2)D(3) are known. This review aims to provide an overview on vitamin D signaling from the skin perspective.

journal_name

Dermatol Clin

journal_title

Dermatologic clinics

authors

Carlberg C,Seuter S

doi

10.1016/j.det.2007.06.004

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

515-23, viii

issue

4

eissn

0733-8635

issn

1558-0520

pii

S0733-8635(07)00062-9

journal_volume

25

pub_type

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