Contact dermatitis.

Abstract:

:Contact dermatitis is a common skin disease caused by contact with irritants or allergens. Irritant contact dermatitis is a result of nonspecific irritant factors, which cause activation of mainly innate immunity, resulting in skin inflammation. Contact hypersensitivity, which manifests itself as allergic contact dermatitis, is result of adaptive immune response, where sensitization to hapten-carrier complexes leads to T-cell-mediated contact allergy. Subsequent contact with the hapten results in skin inflammation. This review concentrates on the role of cutaneous receptors in contact dermatitis and highlights potential targets for treatment interventions.

journal_name

Dermatol Clin

journal_title

Dermatologic clinics

authors

Fyhrquist-Vanni N,Alenius H,Lauerma A

doi

10.1016/j.det.2007.06.002

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

613-23, x

issue

4

eissn

0733-8635

issn

1558-0520

pii

S0733-8635(07)00060-5

journal_volume

25

pub_type

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