Abstract:
:Contact dermatitis is a common skin disease caused by contact with irritants or allergens. Irritant contact dermatitis is a result of nonspecific irritant factors, which cause activation of mainly innate immunity, resulting in skin inflammation. Contact hypersensitivity, which manifests itself as allergic contact dermatitis, is result of adaptive immune response, where sensitization to hapten-carrier complexes leads to T-cell-mediated contact allergy. Subsequent contact with the hapten results in skin inflammation. This review concentrates on the role of cutaneous receptors in contact dermatitis and highlights potential targets for treatment interventions.
journal_name
Dermatol Clinjournal_title
Dermatologic clinicsauthors
Fyhrquist-Vanni N,Alenius H,Lauerma Adoi
10.1016/j.det.2007.06.002subject
Has Abstractpub_date
2007-10-01 00:00:00pages
613-23, xissue
4eissn
0733-8635issn
1558-0520pii
S0733-8635(07)00060-5journal_volume
25pub_type
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