Human papillomavirus infection and neoplasia. Speculations for the future.


:Human papillomavirus infections of the skin and anogenital tract are common. The association of these viruses with neoplasia, particularly of the anogenital tract, has stimulated efforts to devise practical methods of detection and typing of HPV. Although experimental diagnostic tests are available, they are, for the most part, complex and time consuming and are limited to medical centers researching HPV. New methods for preparing probes with higher sensitivities for hybridization tests will allow use of in situ methods on formalin-fixed tissues and will probably be the method of choice. Antigen detection systems are not available, except for antisera directed against the common structural antigens. The most useful immunologic test will be directed toward detection of nonstructural antigens in fixed tissues; such a system could also be useful for virus typing. Therapies based on use of these antigens to stimulate the immune system may be applicable as an alternative to current therapies. Most intriguing are the prospects for a vaccine based on either structural or nonstructural viral antigens. It has been estimated that as many as 20% of cancer deaths in women worldwide are associated with HPV. Thus, use of an effective vaccine would relieve considerable human suffering. Until the host immune response to HPV infection is better defined, however, much of the effort dedicated to developing a vaccine may be futile.


Dermatol Clin


Dermatologic clinics


Lancaster WD,Jenson AB


Has Abstract


1991-04-01 00:00:00












  • Quality of life in pediatric dermatology.

    abstract::Skin disease is highly prevalent in the United States, and it has been well-documented that patients with skin disease experience financial, psychological, social, and quality-of-life (QoL) burdens beyond those of the general population. Pediatric patients and their caregivers are particularly vulnerable to the burden...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审


    authors: Brown MM,Chamlin SL,Smidt AC

    更新日期:2013-04-01 00:00:00

  • Dermatologic side effects of psychopharmacologic agents.

    abstract::Exanthematous eruptions, urticaria, photosensitivity, pigmentary problems, acne, alopecia, fixed drug eruptions, and lichenoid reactions are the most common dermatologic side effects associated with the administration of psychopharmacologic agents. The cutaneous findings associated with the various eruptions and the m...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审


    authors: Garnis-Jones S

    更新日期:1996-07-01 00:00:00

  • Systemic retinoid therapy.

    abstract::Systemic retinoids represent a growing armamentarium in the treatment of a wide range of skin disorders and malignancies. Although these drugs can have substantial toxicities, their wise use can result in safe and efficacious therapy that can alter dramatically the lives of individuals with severe skin disorders. ...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审


    authors: DiGiovanna JJ

    更新日期:2001-01-01 00:00:00

  • Advanced laboratory techniques at the Armed Forces Institute of Pathology applicable to diagnosis and research in dermatology.

    abstract::The Armed Forces Institute of Pathology (AFIP) is well known for providing expert pathology in many specialties and educational courses for civilian and military personnel. Some of the departments at the AFIP have also developed expertise in various advanced laboratory techniques for diagnosis and research that are ap...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审


    authors: Skelton HG,O'Leary TJ,Hilyard EJ,Smith KJ

    更新日期:1999-01-01 00:00:00

  • The vitamin D receptor.

    abstract::The vitamin D endocrine system is known for its essential role in calcium homeostasis and bone metabolism, and induces cell differentiation, inhibits cell growth, controls other hormonal systems, and modulates the immune response. Vitamin D(3) is a prohormone that is taken up by diet or synthesized in ultraviolet radi...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审


    authors: Carlberg C,Seuter S

    更新日期:2007-10-01 00:00:00

  • Psoriasis: the future.

    abstract::The umbrella term psoriasis is now understood to incorporate several distinct phenotypes or endotypes along the disease spectrum that in turn will dictate different therapies. A stratified medicine approach to psoriasis using this clinical information coupled with pharmacogenomic and immunologic data will become more ...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审


    authors: Menter MA,Griffiths CE

    更新日期:2015-01-01 00:00:00

  • Therapeutic approaches to patients with mucous membrane pemphigoid.

    abstract::The therapeutic approach to mucous membrane pemphigoid is site specific, with the goal of preserving function for patients with chronic and treatment-resistant disease. The involvement of certain mucosal sites (ie, ocular, laryngeal, esophageal, nasopharyngeal, and anogenital) is high risk and warrants more aggressive...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审


    authors: Kourosh AS,Yancey KB

    更新日期:2011-10-01 00:00:00

  • Tips to treat the 5 most common nail disorders: brittle nails, onycholysis, paronychia, psoriasis, onychomycosis.

    abstract::Nail disorders are difficult to treat and often frustrating both for patients and clinicians. Because of the slow growth rate of the nail plate and the difficulty of getting the drug actives to penetrate the nail tissues, it is usually necessary to wait several months before seeing the results of treatments. This dela...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审


    authors: Iorizzo M

    更新日期:2015-04-01 00:00:00

  • Success and failure in gonorrhea control.

    abstract::This article has shown that all the necessary components for successful control of gonorrhea are available. In developed countries, general improvements in economic conditions and advances in treatment and diagnosis have resulted in the lowest incidence rates of gonorrhea ever. Within these countries, however, control...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章


    authors: Low N,FitzGerald MR

    更新日期:1998-10-01 00:00:00

  • Sunscreens and hair photoprotection.

    abstract::Photoprotection as it pertains to hair is not a common topic addressed by the dermatologist. Hair is nonliving and requires no protection from ultraviolet (UV) radiation because carcinogenesis of the hair shaft itself is not possible. If hair proteins are altered by sun exposure, damaged hair can be removed and replac...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章


    authors: Draelos ZD

    更新日期:2006-01-01 00:00:00

  • Diaper dermatitis.

    abstract::Diaper dermatitis is a term used to encompass a wide range of inflammatory processes that occur in the area covered by the diaper. The term "diaper dermatitis" is thus simply a description of the location of a rash. Numerous factors can be involved in the pathogenesis of dermatitis in the diaper area. These factors, i...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章


    authors: Leyden JJ

    更新日期:1986-01-01 00:00:00

  • The evolution of soft tissue fillers in clinical practice.

    abstract::To remain experts in skin care and treatment, every dermatologist must be aware of the evolving role of soft tissue fillers in dermatology. Patients with facial scarring, lipodystrophy, contour abnormalities, and age- and sun-induced rhytids can be successfully treated. A literature review, industry recommendations, a...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审


    authors: Murray CA,Zloty D,Warshawski L

    更新日期:2005-04-01 00:00:00

  • Cutaneous schistosomiasis.

    abstract::Schistosomiasis is the name given to a group of diseases caused by trematodes of the genus Schistosome. Humans and other animals are definitive hosts, and snails of various genera are intermediate hosts. This article reviews the epidemiology, pathology, cutaneous manifestations, and treatment of these diseases. ...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审


    authors: Amer M

    更新日期:1994-10-01 00:00:00

  • Cutaneous vascular disorders associated with internal malignancy.

    abstract::This article provides a detailed review of the vascular manifestations affecting the skin in relationship to internal malignancies. Vascular abnormalities heralding internal malignancies can be divided into three main categories, consisting of disorders related to vascular dilatation (flushing, palmar erythema, and te...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审


    authors: El Tal AK,Tannous Z

    更新日期:2008-01-01 00:00:00

  • Antiviral treatment of diseases in pediatric dermatology.

    abstract::Pediatric dermatologic disease that have specific therapies and/or specific prophylactic measures are reviewed. Herpes simplex virus and varicella-zoster virus infections, human papillomavirus infections, and molluscum contagiosum infections are discussed with special emphasis on recent advances of therapy and prophyl...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审


    authors: Trizna Z,Tyring SK

    更新日期:1998-07-01 00:00:00

  • Repair of large and difficult-to-close wounds.

    abstract::Large defects may at first appear to be too big to close in a side-to-side fashion. Certain wounds and situations may call for healing with second intent. Undermining and pulley sutures are very helpful in bringing together wound edges of certain large openings. Partial closures may decrease the tendency to exert unwa...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章


    authors: Shelton RM

    更新日期:2001-07-01 00:00:00

  • Pemphigus.

    abstract::Pemphigus is an autoimmune intraepithelial blistering disease of the skin and mucous membranes that is characterized in part by the presence of circulating IgG autoantibodies. These autoantibodies, which have been shown to be pathogenic, bind to complexes on the keratinocyte cell surface and have been utilized to esta...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审


    authors: Korman NJ

    更新日期:1990-10-01 00:00:00

  • Practice and Educational Gaps in Surgery for Skin Cancer.

    abstract::Surgery for skin cancer is a major part of clinical dermatology, and the largest single component of dermatologic surgery practice. In general, residency training in dermatology provides comprehensive training in the theory and practice of skin cancer surgery. Practicing dermatologists are similarly expert in this are...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审


    authors: Alam M,Waldman A,Maher IA

    更新日期:2016-07-01 00:00:00

  • Aminolevulinic acid-photodynamic therapy for photorejuvenation.

    abstract::Light therapy is widely used in dermatology. An enhancement to his therapy is the use of a photosensitizing medication along with light therapy, known as photodynamic therapy (PDT). PDT is primarily used for the treatment of precancerous lesions, acne vulgaris, and nonmelonoma skin cancer, and has also been shown to i...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章


    authors: Nootheti PK,Goldman MP

    更新日期:2007-01-01 00:00:00

  • The use of psychotropic medications in clinical dermatology.

    abstract::In this article, the use of selected psychopharmacologic medications was explained in detail. If a patient who is obviously suffering from a psychiatric component of his or her disorder that can be responsive to psychopharmacotherapy refuses to accept a referral to a psychiatrist or other mental health professional, t...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章


    authors: Koo JY

    更新日期:1992-07-01 00:00:00

  • Idiopathic gingivostomatitis.

    abstract::Atypical gingivostomatitis is recognized by a combination of clinical findings, a sharply marginated, deep red edematous quality to the attached gingiva, angular cheilitis, and a sore red tongue. Unfortunately, there are no general laboratory tests that are diagnostic of the condition, although biopsy of the gingiva s...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审


    authors: Perry HO

    更新日期:1987-10-01 00:00:00

  • When antibiotics are unnecessary.

    abstract::Dermatologists can decrease unnecessary use of antimicrobial agents by avoiding them in situations wherein good evidence indicates that they are ineffective. Controlled trials indicate that antimicrobial agents are unhelpful in treating cutaneous abscesses, inflamed epidermal cysts, uninfected atopic eczema, and cutan...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审


    authors: Hirschmann JV

    更新日期:2009-01-01 00:00:00

  • Genetic basis of alopecia areata: a roadmap for translational research.

    abstract::Alopecia areata (AA) is a recurrent autoimmune type of hair loss that affects about 5.3 million people in the United States alone. Despite being the most prevalent autoimmune disease, the molecular and cellular mechanisms underlying this complex disease are still poorly understood, and rational treatments are lacking....

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审


    authors: Jabbari A,Petukhova L,Cabral RM,Clynes R,Christiano AM

    更新日期:2013-01-01 00:00:00

  • Evaluation and Management of Refractory Acne Vulgaris in Adolescent and Adult Men.

    abstract::Acne vulgaris alters the normal skin physiology, impairing stratum corneum and transepidermal water loss. A male's normal skin physiologic state is different than a female's and may have implications when choosing treatment when the skin is altered in a disease state. Transepidermal water loss, pH, and sebum productio...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审


    authors: McCarty M

    更新日期:2016-04-01 00:00:00

  • Chromoblastomycosis.

    abstract::Chromoblastomycosis is a chronic cutaneous infection due to several varieties of pigmented fungi. Diagnosis is straightforward and based on clinical and microscopic findings. Despite the protracted course of the disease, dissemination of the infection is rare. New insights into the pathophysiology may permit a closer ...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审


    authors: Elgart GW

    更新日期:1996-01-01 00:00:00

  • Pigmented nail disorders.

    abstract::Nail pigmentation is defined by the presence of melanin in the nail plate. It most frequently has the appearance of a longitudinal pigmented band, called longitudinal mel-anonychia (LM). LM is an important aspect of ungual pathology because it can be the first sign of nail apparatus melanoma. The aim of this article i...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审


    authors: André J,Lateur N

    更新日期:2006-07-01 00:00:00

  • Teledermatology: how to start a new teaching and diagnostic era in medicine.

    abstract::"Telemedicine" is defined as the use of telecommunication technologies for the exchange of medical information across distances. Applications include patient management as well as research and education. Teledermatology is a steadily growing category of telemedicine. This article presents general aspects of telemedici...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审


    authors: Wurm EM,Campbell TM,Soyer HP

    更新日期:2008-04-01 00:00:00

  • Histoplasmosis.

    abstract::Histoplasmosis is caused by Histoplasma capsulatum, a dimorphic fungus. Because histoplasmosis is usually a self-limited disease in the majority of cases, treatment often is not needed in the normal host. However, severe cases of acute pulmonary histoplasmosis require therapy. Amphotericin B is considered the treatmen...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审


    authors: Dijkstra JW

    更新日期:1989-04-01 00:00:00

  • Toward a human papillomavirus vaccine.

    abstract::Much progress has been made over the past 10 years with regard to development of a vaccine active against HPV. Successful protection has been achieved in animal models using species-specific papillomaviruses; however, HPV diversity may delay the development of successful HPV vaccines, especially those designed as ther...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章


    authors: Rowen D,Lacey C

    更新日期:1998-10-01 00:00:00

  • Chronic telogen effluvium.

    abstract::Chronic telogen effluvium is not uncommon. It is a form of diffuse hair loss affecting the entire scalp for which no obvious cause can be found. It usually affects women of 30 to 60 years of age who generally have a full head of hair prior to the onset of shedding. The onset is usually abrupt, with or without a recogn...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章


    authors: Whiting DA

    更新日期:1996-10-01 00:00:00