Abstract：
:If one looks at the development of most drugs, it becomes evident that an extended period of time is necessary before the proper use and full range of activities of the drug in treating human disease become apparent. In many cases, initial treatment failures are due to faulty expectations as well as inadequate dosing and delivery systems. It is my opinion that growth factor therapy will follow a similar course but that it ultimately will have a role in the modulation of wound repair.
journal_name
Dermatol Clinjournal_title
Dermatologic clinicsauthors
Falanga Vsubject
Has Abstractpub_date
1993-10-01 00:00:00pages
667-75issue
4eissn
0733-8635issn
1558-0520journal_volume
11pub_type
杂志文章,评审abstract：:Guttate and plaque psoriasis are regarded as variants of one disease but present with distinct clinical and histologic appearances. This article focuses special attention on different pathways in the development and clinical course of each, with emphasis on immunologic correlations regarding HLA system linkage and the...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1995-10-01 00:00:00
abstract：:The work described in this article reveals a remarkable lack of consensus as to whether percutaneous absorption changes as humans grow older. The data that have been recorded point to possible significant alterations in the barrier function with age. The importance of these observations with respect to dermatopharmaco...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1986-07-01 00:00:00
abstract：:This article, rather than presenting an overview of all available antifungal agents, has provided an update on new information about older agents, as well as evolving information about new agents, including those currently undergoing clinical trials. Among the azoles, ketoconazole will continue to be used as a major a...
journal_title：Dermatologic clinics
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
abstract：:Light therapy is widely used in dermatology. An enhancement to his therapy is the use of a photosensitizing medication along with light therapy, known as photodynamic therapy (PDT). PDT is primarily used for the treatment of precancerous lesions, acne vulgaris, and nonmelonoma skin cancer, and has also been shown to i...
journal_title：Dermatologic clinics
pub_type： 杂志文章
doi：10.1016/j.det.2006.09.010
更新日期：2007-01-01 00:00:00
abstract：:Colored cosmetics are an important part of the dermatologic armamentarium. They can camouflage contour and pigment abnormalities, provide moisturization, enhance oil control, add sun protection, deliver barrier-enhancing agents, increase acne treatment, and create a sense of personal well-being. Familiarity with these...
journal_title：Dermatologic clinics
pub_type： 杂志文章
doi：10.1016/s0733-8635(05)70213-8
更新日期：2000-10-01 00:00:00
abstract：:Black patients who desire cosmetic surgery have not had many treatment options or services available to them. At this time, the requests for specific cosmetic surgical procedures by black patients have far exceeded the number of cosmetic surgeons able to meet their needs. A surgeon who calls himself or herself a cosme...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1988-07-01 00:00:00
abstract：:Multiple strategies are required to combat the increasing incidence and mortality of cutaneous melanoma. Major questions about melanoma and skin cancer are reviewed, with particular attention to education and early detection. ...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1995-07-01 00:00:00
abstract：:A hypothesis is proposed for the etiopathogenesis of some cases of Hodgkin's disease, Sezary's syndrome, and related disorders that compose the cutaneous T-cell lymphoma group. This new model, termed the thymus bypass model, is discussed in detail in this article. ...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1994-04-01 00:00:00
abstract：:Current aesthetic dermatology rejuvenation options offer minimally invasive, more affordable alternatives to traditional cosmetic surgery. Chemical peels and laser resurfacing can significantly improve the appearance of the skin and stimulate neocollagenesis; botulinum toxin reduces the appearance of dynamic facial li...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2009.08.013
更新日期：2009-10-01 00:00:00
abstract：:The diagnosis of lymphoma currently relies on a combination of clinical, routine histopathologic, and immunohistochemical studies, sometimes supplemented by other special techniques such as flow cytometry, DNA analysis, and gene rearrangement study. This review considers the practical diagnosis of cutaneous lymphoma, ...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1992-01-01 00:00:00
abstract：:It is quite evident the pathogenesis of psoriasis is modulated by immune-mediated mechanisms that invoke activated T cells and inflammatory cytokines, such as tumor necrosis factor-alpha. Current immunosuppressive systemic treatments may be effective in controlling psoriasis to a certain degree but have significant dr...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2003.12.002
更新日期：2004-10-01 00:00:00
abstract：:"Telemedicine" is defined as the use of telecommunication technologies for the exchange of medical information across distances. Applications include patient management as well as research and education. Teledermatology is a steadily growing category of telemedicine. This article presents general aspects of telemedici...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2007.12.003
更新日期：2008-04-01 00:00:00
abstract：:Photoaggravated skin disorders are diseases that occur without UV radiation but are sometimes or frequently exacerbated by UV radiation. In conditions, such as lupus erythematosus, photoaggravation occurs in a majority of patients, whereas in conditions, such as psoriasis and atopic dermatitis, only a subset of patien...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2014.03.008
更新日期：2014-07-01 00:00:00
abstract：:Autoinflammatory diseases (AIDs) are characterized by recurrent episodes of systemic and organ-specific inflammation. Many of these diseases share fever as a common presenting feature. Physicians need to consider AIDs in children with recurrent, unexplained fevers, when infectious and malignant causes have been discar...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2013.04.003
更新日期：2013-07-01 00:00:00
abstract：:Among the different classes and complexities of antiretroviral regimens, maximal viral suppression, sustained durability, increased CD4 count, decreased evolving resistance, and fewer side effects combined with increased compliance resulting in decreased morbidity and mortality remain the goals of therapy. Serial vira...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8635(05)70314-4
更新日期：2001-10-01 00:00:00
abstract：:Cutaneous manifestations of thyroid disease are protean in nature and can be divided into specific lesions such as the thyroglossal duct cyst and cutaneous metastases from thyroid malignancy, nonspecific signs secondary to thyroid hormone imbalance, and associated dermatologic and systemic disorders. This review repre...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8635(02)00009-8
更新日期：2002-07-01 00:00:00
abstract：:There is a dearth of information on psoriasis in the tropics. Psoriasis occurs more frequently in northern geographic regions than in tropical climates. Its prevalence varies not only within the ethnic groups of a country but from country to country. A review of published studies on the natural history of psoriasis in...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1994-10-01 00:00:00
abstract：:The only spiders of real medical importance to humans in the United States are the Loxosceles and Latrodectus species, primarily the brown recluse and the black window, respectively. These spiders bite humans only when trapped or crushed against the skin. Severe brown recluse spider bites produce dermonecrosis within ...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1990-04-01 00:00:00
abstract：:In this article, the use of selected psychopharmacologic medications was explained in detail. If a patient who is obviously suffering from a psychiatric component of his or her disorder that can be responsive to psychopharmacotherapy refuses to accept a referral to a psychiatrist or other mental health professional, t...
journal_title：Dermatologic clinics
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
abstract：:Primary cutaneous lymphomas comprise a prognostically heterogeneous group of lymphocytic skin neoplasms, which display a broad spectrum of clinical, histologic, immunophenotypic, and genetic features. The histopathological examination plays an essential role and is often the starting point in the diagnostic workup of ...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2015.05.002
更新日期：2015-10-01 00:00:00
abstract：:With simple, inexpensive therapy, virtually all venous ulcers heal without the need for hospitalization, skin grafting, growth factors, hyperbaric oxygen, or debilitating bed rest. Although the future promises to yield a greater understanding about the nature of these wounds and ways to treat them, one can benefit the...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1993-10-01 00:00:00
abstract：:Though history will mark June 1981 as the birthday of the AIDS pandemic, the first true case of the syndrome and its cause originated years before in West-Central Africa. History also highlights the irony that the discovery of AIDS, the detection of its cause, and the development of drugs for its treatment, all occurr...
journal_title：Dermatologic clinics
pub_type： 历史文章,杂志文章
doi：10.1016/j.det.2006.05.001
更新日期：2006-10-01 00:00:00
abstract：:Many lesions that appear in the oral cavity manifest as a nodule or swelling. A particular lesion may have the clinical characteristics of several entities, and a differential diagnosis should be generated, with a final diagnosis reached by microscopic examination. This article discusses and shows the clinical feature...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8635(05)70362-4
更新日期：1996-04-01 00:00:00
abstract：:Use of the dissecting stereomicroscope during hair transplant graft dissection has been advocated as a means of reducing hair follicle transection and improving graft growth. The study evaluated the prevalence of hair follicle transection in grafts prepared with and without the dissecting stereomicroscope. Approximate...
journal_title：Dermatologic clinics
pub_type： 杂志文章,多中心研究
doi：10.1016/s0733-8635(05)70089-9
更新日期：1999-04-01 00:00:00
abstract：:Reports of fatalities following liposuction have lead to investigations by state medical boards. The risk of complications and fatalities is clearly different for liposuction under local anesthesia and intravenous sedation. Thousands of patients have been treated with true tumescent liposuction as described by dermato...
journal_title：Dermatologic clinics
pub_type： 杂志文章
doi：10.1016/s0733-8635(05)70137-6
更新日期：1999-10-01 00:00:00
abstract：:Pigmentary disorders are common and can be very distressing to patients. There is a need for better, standardized therapies. The authors review the most recent data for topical, systemic, light, and laser treatments for vitiligo, melasma, and postinflammatory hyperpigmentation. There is a paucity of large-scale, well-...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2018.12.008
更新日期：2019-04-01 00:00:00
abstract：:Pemphigus is an autoimmune intraepithelial blistering disease of the skin and mucous membranes that is characterized in part by the presence of circulating IgG autoantibodies. These autoantibodies, which have been shown to be pathogenic, bind to complexes on the keratinocyte cell surface and have been utilized to esta...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1990-10-01 00:00:00
abstract：:This article describes major screening studies of the past two decades, discusses the evidence-based screening recommendations, highlights the need to screen high-risk and previously unscreened populations, and concludes with suggestions for risk assessment and physician-nurse training in the skin cancer examination. ...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8635(02)00034-7
更新日期：2002-10-01 00:00:00
abstract：:Large defects may at first appear to be too big to close in a side-to-side fashion. Certain wounds and situations may call for healing with second intent. Undermining and pulley sutures are very helpful in bringing together wound edges of certain large openings. Partial closures may decrease the tendency to exert unwa...
journal_title：Dermatologic clinics
pub_type： 杂志文章
doi：10.1016/s0733-8635(05)70294-1
更新日期：2001-07-01 00:00:00
abstract：:This article is a tribute to clinician Henry M. Lewis. The author shares practical therapeutic pearls developed and used over the years by Dr. Lewis. ...
journal_title：Dermatologic clinics
pub_type： 传,历史文章,杂志文章
doi：
更新日期：1989-01-01 00:00:00
