当前位置： SCI文献检索 > OBSTETRICS AND GYNECOLOGY期刊下所有文献 > Outcome at 3 years of age in a population-based cohort of extremely preterm infants.

Outcome at 3 years of age in a population-based cohort of extremely preterm infants.

Abstract：

OBJECTIVE:To assess health and neurodevelopmental outcome at 3 years of age in neonatal intensive care unit (NICU)-surviving children who were born at 26 or fewer weeks of gestation in a geographically defined region of Belgium from 1999 through 2000. METHODS:The study included a clinical examination and a standardized neurologic and developmental assessment. Disabilities were defined by international criteria. In 97% (92 of 95) of the children, accurate information on the presence of overall disability could be collected. RESULTS:Thirty-six percent (95% confidence interval [CI] 25-47%) of the formally assessed children (28 of 77) had deficient neuromotor development, with 5% of them showing severe sensory-communicative impairment. Mean (+/-standard deviation) scores on the Mental Developmental Index and Psychomotor Developmental Index were 81.2 (18.8) and 73.2 (17.8), respectively. Seventy percent (95% CI 60-80%) had a mental (Mental Developmental Index) or psychomotor (Psychomotor Developmental Index) impairment or both, assessed to be more than 1 standard deviation below the population mean. Mental and psychomotor outcome did not differ significantly when compared according to either gestational age, gender, or multiple birth (all P>.05). When either minor central dysfunction or cerebral palsy was not taken into account, normal mental development was recorded in 62% of the subjects. The cumulative of poor outcome (ie, disability- or prematurity-related death) among the 95 infants discharged alive was estimated to be 58% (95% CI 48-68%), representing 25 (26%) mildly-to-moderately disabled and 28 (29%) severely disabled toddlers, including two infants whose postdischarge deaths were directly related to prematurity. CONCLUSION:The average developmental outcome is poor in children born as extremely preterm infants. Finding early predictors of adverse outcome is a major challenge.

journal_name

Obstet Gynecol

journal_title

Obstetrics and gynecology

authors

De Groote I,Vanhaesebrouck P,Bruneel E,Dom L,Durein I,Hasaerts D,Laroche S,Oostra A,Ortibus E,Roeyers H,van Mol C,Extremely Preterm Infants in Belgium (EPIBEL) Study Group.

doi

10.1097/01.AOG.0000284447.43442.55

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

855-64

issue

eissn

0029-7844

issn

1873-233X

pii

110/4/855

journal_volume

110

pub_type

杂志文章

在线工具

Outcome at 3 years of age in a population-based cohort of extremely preterm infants.