Development and validation of a nomogram for predicting outcome of patients with vulvar cancer.

Abstract:

OBJECTIVE:To construct and validate a nomogram to predict relapse-free survival of patients treated for vulvar cancer. METHODS:Data from 244 patients treated for vulvar cancer at a single institution (Creteil, France) were used as a training set to develop and calibrate a nomogram for predicting relapse-free survival and local relapse-free survival. We used bootstrap resampling for the internal validation and we tested the nomogram on an independent validation set of patients (Torino, Italy) for the external validation. RESULTS:The nomograms were based on a Cox proportional hazards regression model. Covariates for the relapse-free survival model included age, T stage, number of metastatic nodes, bilateral lymph node involvement, omission of the lymphadenectomy, margin status, lymphovascular space invasion, and depth of invasion. The concordance indices were 0.85 and 0.83 in the training set before and after bootstrapping, respectively, and 0.83 in the validation set. The predictions of our nomogram discriminated better than did the International Federation of Gynecology and Obstetrics stage (0.83 compared with 0.78, P = .01). The calibration of our nomogram was good. In the validation set, 2-year and 5-year relapse-free survival were well predicted with less than 5% difference between the predicted and observed survivals for each quartile. A nomogram for predicting local relapse was also developed. CONCLUSION:We have developed nomograms for predicting distant and local relapse of vulvar cancer at 2 and 5 years and validated them both internally and externally. These nomograms will be freely available on the International Society for the Study of Vulvovaginal Disease Web site. LEVEL OF EVIDENCE:III.

journal_name

Obstet Gynecol

authors

Rouzier R,Preti M,Haddad B,Martin M,Micheletti L,Paniel BJ

doi

10.1097/01.AOG.0000198639.36855.e9

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

672-7

issue

3

eissn

0029-7844

issn

1873-233X

pii

107/3/672

journal_volume

107

pub_type

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