Abstract：
OBJECTIVE:To evaluate whether myo-inositol supplementation, an insulin sensitizer, reduces the rate of gestational diabetes mellitus (GDM) and lowers insulin resistance in obese pregnant women. METHODS:In an open-label, randomized trial, myo-inositol (2 g plus 200 micrograms folic acid twice a day) or placebo (200 micrograms folic acid twice a day) was administered from the first trimester to delivery in pregnant obese women (prepregnancy body mass index 30 or greater. We calculated that 101 women in each arm would be required to demonstrate a 65% GDM reduction in the myo-inositol group with a statistical power of 80% (α=0.05). The primary outcomes were the incidence of GDM and the change in insulin resistance from enrollment until the diagnostic oral glucose tolerance test. RESULTS:From January 2011 to April 2014, 220 pregnant women at 12-13 weeks of gestation were randomized at two Italian university hospitals, 110 to myo-inositol and 110 to placebo. Most characteristics were similar between groups. The GDM rate was significantly reduced in the myo-inositol group compared with the control group, 14.0% compared with 33.6%, respectively (P=.001; odds ratio 0.34, 95% confidence interval 0.17-0.68). Furthermore, women treated with myo-inositol showed a significantly greater reduction in the homeostasis model assessment of insulin resistance compared with the control group, -1.0±3.1 compared with 0.1±1.8 (P=.048). CONCLUSION:Myo-inositol supplementation, started in the first trimester, in obese pregnant women seems to reduce the incidence in GDM through a reduction of insulin resistance. CLINICAL TRIAL REGISTRATION:ClinicalTrials.gov, www.clinicaltrials.gov, NCT01047982.
journal_name
Obstet Gynecoljournal_title
Obstetrics and gynecologyauthors
D'Anna R,Di Benedetto A,Scilipoti A,Santamaria A,Interdonato ML,Petrella E,Neri I,Pintaudi B,Corrado F,Facchinetti Fdoi
10.1097/AOG.0000000000000958subject
Has Abstractpub_date
2015-08-01 00:00:00pages
310-315issue
2eissn
0029-7844issn
1873-233Xpii
00006250-201508000-00014journal_volume
126pub_type
杂志文章,随机对照试验abstract：:This report describes an innovative use of videography in teaching retropubic space anatomy and surgery. After the standard abdominal incision has been made, the second surgical assistant places a gynecologic laparoscope, fitted with an endoscopic camera, into the retropubic space and guides the laparoscope documentin...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1991-04-01 00:00:00
abstract：:Women who develop preeclampsia during pregnancy excrete less calcium than healthy pregnant women. Whether this reduction in calcium excretion precedes or follows hypertension is unknown. We prospectively measured urinary calcium excretion in 103 consecutive nulliparous women at risk for preeclampsia and presenting for...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1991-05-01 00:00:00
abstract：OBJECTIVE:To assess the relationship of preinsertion vaginal ultrasound assessment and menstrual and gynecologic history as predictors of difficult or painful intrauterine device insertion in nulligravid women. METHODS:Nulligravid women seeking contraception were invited to participate in this nonrandomized study and ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0000000000000362
更新日期：2014-08-01 00:00:00
abstract：OBJECTIVE:To investigate the ability of fetal urinalysis to predict in utero the renal function of children with bilateral uropathy who survive to the second year of life. METHODS:This was a prospective cohort study of 100 consecutive patients with prenatal diagnosis of bilateral uropathy who underwent fetal urine sam...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1993-11-01 00:00:00
abstract：:The 15-methyl analog of prostaglandin F2 alpha (15-ME-PGF2 alpha), administered in a 3-mg dose via a single vaginal suppository and supplemented at 24 hours by intramuscular injection(s) of 250 micrograms, successfully induced abortion in 80 of 81 patients in the midtrimester of pregnancy. The mean abortion time was 1...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1981-07-01 00:00:00
abstract：:The presence of diffuse abdominal calcification in patients with known carcinoma is usually a sign of metastatic involvement. This finding in some patients who have been treated with high dosage radiation therapy may represent areas of tumor necrosis and subsequent healing without evidence of active malignancy. ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:Fetal macrosomia (birthweight equal to or in excess of 4500 g) in a study of 110 affected infants was associated with excessive maternal weight, prolonged gestation, white race, multiparity, maternal diabetes, male fetus, and a previous macrosomic infant. The two most common obstetric complications associated with fet...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1978-10-01 00:00:00
abstract：OBJECTIVE:To evaluate maternal parity, the sonographic measurement of cervical length, and the five components of the Bishop score to determine which factors best predict the length of latent-phase labor in women undergoing labor induction. METHODS:Cervical position, cervical consistency, cervical effacement, cervical...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0029-7844(96)00321-3
更新日期：1996-12-01 00:00:00
abstract：OBJECTIVE:To study the survival, rates and patterns of recurrence, and perioperative morbidity in medically compromised women with endometrial cancer treated by primary vaginal hysterectomy. METHODS:Fifty-one patients with endometrial cancer treated initially by vaginal hysterectomy between 1977 and 1999 were identifi...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：2001-05-01 00:00:00
abstract：:The effects of the suboptimal temperature caused by delayed incubation or prolonged transport on the recovery of Neisseria gonorrhoeae were studied in 2 separate patient populations. The individual components of the John E. Martin Biological Environmental Chamber were used to define more precisely other variables that...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1982-05-01 00:00:00
abstract：OBJECTIVE:To investigate whether the 2006 American Society for Colposcopy and Cervical Pathology guidelines for conservative management of minimally abnormal Pap test results (atypical squamous cells of undetermined significance, human papillomavirus-positive, and low-grade squamous intraepithelial lesions) and moderat...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0b013e31824e9f2f
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND:Pulmonary sequestration is not believed to be familial. We report two male infants with this anomaly who were born to the same parents. CASES:The prenatal diagnosis of pulmonary sequestration was made in a woman's two consecutive pregnancies by demonstrating systemic arterial supply to an echogenic mass loc...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1996-05-01 00:00:00
abstract：:Tubal pregnancy specimens from a patient with undetectable serum beta-hCG levels and a control case with a low beta-hCG titer by radioimmunoassay were analyzed using peroxidase-antiperoxidase immunocytochemical localization of placental proteins. The results indicated that deficient production of beta-hCG by ectopic t...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1988-06-01 00:00:00
abstract：:Nine reproductive-age women underwent removal of unilateral or bilateral dermoid cysts via laparoscopy. Over a follow-up period of 12-42 months, there were no immediate or long-term complications. Four patients have had repeat laparoscopy for evaluation of possible pelvic adhesion formation; one had mild periovarian a...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1989-02-01 00:00:00
abstract：OBJECTIVE:To estimate whether the time interval between cervical conization and subsequent pregnancy is associated with risk of preterm birth. METHODS:Our study is a case control study nested in a retrospective cohort. Women who underwent colposcopic biopsy or conization with loop electrosurgical excision procedure, l...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/01.AOG.0000251497.55065.74
更新日期：2007-02-01 00:00:00
abstract：:We reviewed our experience with a policy of revising the estimated probability of an open neural tube defect for those cases in which maternal serum alpha-fetoprotein (MSAFP) was elevated and the ultrasound examination was normal. Assuming a sensitivity for the ultrasound diagnosis of neural tube defects of 90%, the r...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1988-02-01 00:00:00
abstract：:Immediate postpartum long-acting reversible contraception (LARC) has the potential to reduce unintended and short-interval pregnancy. Women should be counseled about all forms of postpartum contraception in a context that allows informed decision making. Immediate postpartum LARC should be offered as an effective opti...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0000000000001583
更新日期：2016-08-01 00:00:00
abstract：:The histories of 386 patients with untreated hydatidiform mole were reviewed to define the clinical aspects of accompanying theca lutein cysts. These cysts occurred in 102 patients (26.4%), with three patients experiencing cyst-related complications. Mean cyst size at diagnosis was 7.3 cm (3-20 cm), and did not correl...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
abstract：BACKGROUND:Bombay blood type is among the rarest in the world and is associated with anti-H antibodies. These antibodies cause severe hemolysis when exposed to any blood product except Bombay and have been reported to cause hemolytic disease of the newborn. CASE:A primigravid woman with Bombay blood type received eryt...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0b013e3181f738f3
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVES:To estimate the prevalence of urinary tract injury and the relative risk of litigation from an injury for benign gynecologic surgery in Canada and to analyze a subset of cases of litigation, determining independent risk factors that predicted medical and legal outcomes. METHODS:The prevalence of urinary tra...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/01.AOG.0000144127.78481.8c
更新日期：2005-01-01 00:00:00
abstract：:Uteri obtained at the postmortem examination of 164 girls ranging in age from premature and immature infants to 11 years were studied for evidence regarding the developmental changes that take place in the cervix during this period of life and in particular the mechanisms involved in the production and regression of c...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1976-05-01 00:00:00
abstract：:A patient with non-mosaic Turner syndrome and normal fertility had four documented pregnancies, two of which were carried to term. Although her fertility history can be considered normal, she did not have spontaneous sexual maturation or menarche, and bilateral streak gonads were identified on laparotomy for tubal lig...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1985-03-01 00:00:00
abstract：:The present study is concerned with surveillance/management programs for hereditary ovarian cancer syndromes. These syndromes lack distinguishing premonitory physical signs or biomarkers; therefore, in these genotypic settings, ovarian cancer risk must be assessed by analysis of the patient's pedigree. The authors des...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1982-05-01 00:00:00
abstract：OBJECTIVE:To estimate the detection rate of abnormalities by transvaginal ultrasound in early pregnancy. METHODS:We prospectively analyzed records of 3592 sequential pregnant women at 10-16 weeks' (singleton) gestation (mean 13 weeks and 2 days). After exclusion of 114 women, there were 3478 women in the study. Each w...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0029-7844(00)00951-0
更新日期：2000-09-01 00:00:00
abstract：OBJECTIVE:To examine the results of a quality-improvement study that implemented an enhanced recovery after surgery (ERAS) program for cesarean delivery. METHODS:A pre-post design was used to assess changes in opioid use, length of stay, and costs among all patients undergoing cesarean delivery before and after implem...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0000000000004023
更新日期：2020-10-01 00:00:00
abstract：OBJECTIVE:We examined chronic pelvic pain definitions used in published research, because the definition has direct implications for investigating causation and evaluating treatment. DATA SOURCES:MEDLINE was searched for published articles in an Abridged Index Medicus journal from 1966 to 2001, restricted to humans, f...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,评审
doi：10.1097/01.AOG.0000115513.92318.b7
更新日期：2004-04-01 00:00:00
abstract：:Pelvic organ prolapse (POP) is a common, benign condition in women. For many women it can cause vaginal bulge and pressure, voiding dysfunction, defecatory dysfunction, and sexual dysfunction, which may adversely affect quality of life. Women in the United States have a 13% lifetime risk of undergoing surgery for POP ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,实务指引
doi：10.1097/AOG.0000000000002008
更新日期：2017-04-01 00:00:00
abstract：:A case of endometrioid carcinoma arising in endometriosis of the fallopian tube is described. One case of tubal endometrioid carcinoma has been reported previously, but the entity has not hitherto been recognized among primary fallopian tube tumors. The clinical presentations, histopathology, and pathogenesis of this ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1978-07-01 00:00:00
abstract：:The safety and efficacy of laminaria tents as an adjunct to labor induction near term were examined in a prospective, controlled, and randomized study involving insertion of laminaria into the cervical canal the evening prior to planned induction. Six of 35 subjects in whom laminaria were used entered labor spontaneou...
journal_title：Obstetrics and gynecology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00006250-197805000-00021
更新日期：1978-05-01 00:00:00
abstract：OBJECTIVE:To estimate the prevalence of filled opioid prescriptions after vaginal delivery. METHODS:We conducted a retrospective cohort study of 164,720 Medicaid-enrolled women in Pennsylvania who delivered a liveborn neonate vaginally from 2008 to 2013, excluding women who used opioids during pregnancy or who had an ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0000000000001868
更新日期：2017-03-01 00:00:00
