Abstract：
:A reversed-phase high performance liquid chromatographic (RP-HPLC) method for evaluation of purity of tamsulosin in bulk drugs and pharmaceuticals was developed. The separation was accomplished on an Inertsil C(18) column using 10 mM ammonium acetate: acetonitrile as a mobile phase in a gradient elution mode. A photodiode array detector set at 280 nm was used for detection. The impurities were identified by ESI-MS-MS. The detection limits were 0.06-0.11 microg/ml. The method was validated with respect to accuracy, precision, linearity, ruggedness and limits of detection and quantification. It finds application not only for monitoring the reactions during the process development but also on quality assurance of tamsulosin.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Nageswara Rao R,Kumar Talluri MV,Narasa Raju A,Shinde DD,Ramanjaneyulu GSdoi
10.1016/j.jpba.2007.09.009subject
Has Abstractpub_date
2008-01-07 00:00:00pages
94-103issue
1eissn
0731-7085issn
1873-264Xpii
S0731-7085(07)00515-8journal_volume
46pub_type
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