Forced degradation and impurity profiling: recent trends in analytical perspectives.

Abstract:

:This review describes an epigrammatic impression of the recent trends in analytical perspectives of degradation and impurities profiling of pharmaceuticals including active pharmaceutical ingredient (API) as well as drug products during 2008-2012. These recent trends in forced degradation and impurity profiling were discussed on the head of year of publication; columns, matrix (API and dosage forms) and type of elution in chromatography (isocratic and gradient); therapeutic categories of the drug which were used for analysis. It focuses distinctly on comprehensive update of various analytical methods including hyphenated techniques for the identification and quantification of thresholds of impurities and degradants in different pharmaceutical matrices.

journal_name

J Pharm Biomed Anal

authors

Jain D,Basniwal PK

doi

10.1016/j.jpba.2013.07.013

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

11-35

eissn

0731-7085

issn

1873-264X

pii

S0731-7085(13)00309-9

journal_volume

86

pub_type

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