Endoscopic mucosal resection: not only therapeutic, but a diagnostic procedure for sessile gastric polyps.

Abstract:

BACKGROUND AND AIMS:Histological examination of specimens obtained by forceps biopsy sampling of gastric lesions is of limited accuracy, and their management on this basis is therefore controversial. Endoscopic mucosal resection (EMR) was initially developed in Japan for the resection of early gastric cancer (EGC). The potential use of EMR as a diagnostic tool has been suggested. The aims of the present study were to assess the value of forceps biopsy sampling in establishing the correct diagnosis revealed by EMR and to evaluate the efficacy of EMR. METHODS:Fifty-six subjects with sessile gastric polyps of epithelial origin, at least 0.5 cm in diameter, and not associated with polyposis syndromes, were included. Following forceps biopsy sampling, EMR was performed with an inject-and-cut technique or with cap-fitted methods. The histological results on the forceps biopsy and the resected specimens were analyzed. RESULTS:Histology on the resected specimens revealed neoplastic lesions in 34 cases, including seven EGC, and there were hyperplastic-inflammatory lesions in 21 cases. Complete agreement between the previous histological results of the forceps biopsy samples and the resected specimens was seen in only 76.7% of the lesions. Altogether, the sensitivity and specificity of the forceps biopsy procedure for diagnosing neoplastic lesions were 87.5% (95% confidence interval [CI] = 76.0-98.9%) and 65.2% (95% CI = 45.7-84.7), respectively. A clinically relevant discrimination between neoplastic and non-neoplastic lesions was not achieved in seven cases. No complications, such as perforation or massive bleeding necessitating surgical treatment, were encountered. EMR was considered complete in five patients. None of the EGC recurred during the mean 38-month (6-72) follow up. CONCLUSIONS:Forceps biopsy is not fully representative of the entire lesion, and a simple biopsy may therefore lead to a faulty differentiation between neoplastic and non-neoplastic lesions. EMR proposes diagnostic and staging advantage in assessing patients with EGC as compared to forceps biopsy, because it provides more intact mucosa and submucosa for histological analysis. Sessile gastric polyps should be fully resected by EMR for a final diagnosis and (depending on the lesion size and type) possibly definitive treatment.

authors

Szalóki T,Tóth V,Németh I,Tiszlavicz L,Lonovics J,Czakó L

doi

10.1111/j.1440-1746.2007.05247.x

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

551-5

issue

4

eissn

0815-9319

issn

1440-1746

pii

JGH5247

journal_volume

23

pub_type

杂志文章
  • Expression of Toll-like receptor 4 in rat liver during the course of carbon tetrachloride-induced liver injury.

    abstract:BACKGROUND AND AIM:It has recently been reported that Toll-like receptor 4 (TLR4) is involved in cellular responses to lipopolysaccharides (LPS) and early liver injury induced by LPS. The aim of the present study was to investigate the alterations of TLR4 gene expression in liver tissues and Kupffer cells during the co...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2007.04896.x

    authors: Hua J,Qiu DK,Li JQ,Li EL,Chen XY,Peng YS

    更新日期:2007-06-01 00:00:00

  • Distribution of liver stiffness in non-alcoholic fatty liver disease with higher fibrosis-4 index than low cut-off index.

    abstract:BACKGROUND AND AIM:In the condition of high prevalence of non-alcoholic fatty liver disease (NAFLD), a new diagnostic algorithm to efficiently identify NAFLD patients with significant fibrosis is urgently required. We evaluated the predictive ability of the fibrosis-4 index (FIB-4 index) for significant liver fibrosis ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.14559

    authors: Tomeno W,Imajo K,Kuwada Y,Ogawa Y,Kikuchi M,Honda Y,Kato T,Kessoku T,Kirikoshi H,Yoneda M,Kitahora T,Saito S,Ozawa Y,Nakajima A

    更新日期:2019-08-01 00:00:00

  • Long-term follow up of gastric low-grade mucosa-associated lymphoid tissue lymphoma by endosonography emphasizing the application of a miniature ultrasound probe.

    abstract:BACKGROUND AND AIMS:Endoscopic ultrasonography (EUS) is a useful tool for the evaluation of gastric wall infiltration including gastric lymphoma. The aims of this study were to characterize gastric low-grade mucosa-associated lymphoid tissue (MALT) lymphoma according to EUS findings and to evaluate the role of a miniat...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.2003.02938.x

    authors: Yeh HZ,Chen GH,Chang WD,Poon SK,Yang SS,Lien HC,Chang CS,Chou G

    更新日期:2003-02-01 00:00:00

  • Long-term outcome of autoimmune hepatitis in children.

    abstract:BACKGROUND AND AIM:Autoimmune hepatitis (AIH) is a chronic disease of unknown etiology, which usually progresses to cirrhosis if not diagnosed and treated promptly. Data on long-term follow up in children with AIH are scant. The aim of this study is to assess the long-term outcome of autoimmune hepatitis in children wi...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.2001.02615.x

    authors: Saadah OI,Smith AL,Hardikar W

    更新日期:2001-11-01 00:00:00

  • Pressure-impedance analysis: Assist the diagnosis and classification of ineffective esophageal motility disorder.

    abstract:BACKGROUND AND AIM:We elucidated the clinical significance of distal contractile integral-to-esophageal impedance integral (EII) ratio (DCIIR) in ineffective esophageal motility (IEM) adult patients. METHODS:We recruited 101 patients with IEM (48.38 ± 1.58 years) and 42 matched healthy volunteers (44.28 ± 1.85 years) ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.14981

    authors: Wu JF,Tsai IJ,Tong TW,Lin YC,Yang CH,Tseng PH

    更新日期:2020-08-01 00:00:00

  • Comparison of four current staging systems for Chinese patients with hepatocellular carcinoma undergoing curative resection: Okuda, CLIP, TNM and CUPI.

    abstract:BACKGROUND AND AIM:Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. However, there is no general consensus as to which staging system is the most reliable for predicting the survival of patients with HCC. The aims of this study were to compare commonly-used staging systems in a cohort of Chin...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2008.05527.x

    authors: Lu W,Dong J,Huang Z,Guo D,Liu Y,Shi S

    更新日期:2008-12-01 00:00:00

  • Preventing endoscopic retrograde cholangiopancreatography related sepsis: a randomized controlled trial comparing two antibiotic regimes.

    abstract::Current antibiotic prophylaxis for endoscopic retrograde cholangiopancreatography (ERCP) is not standardized and may be inadequate. We aimed to evaluate the efficacy of 3 days of additional oral antibiotics in the prevention of ERCP-related sepsis. One hundred and fifty-six patients were randomized prospectively to re...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Smith BC,Alqamish JR,Watson KJ,Shaw RG,Andrew JH,Desmond PV

    更新日期:1996-10-01 00:00:00

  • Relationship between local immune response to Helicobacter pylori and the diversity of disease: investigation of H. pylori-specific IgA in gastric juice.

    abstract::In order to evaluate the relationship between local immune response to Helicobacter pylori and the diversity of disease, 77 asymptomatic subjects who underwent a health examination were studied. Helicobacter pylori-specific IgG in serum and H. pylori-specific IgA in gastric juice were measured by ELISA, and the measur...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1997.tb00531.x

    authors: Watanabe T,Goto H,Arisawa T,Hase S,Niwa Y,Hayakawa T,Asai J

    更新日期:1997-10-01 00:00:00

  • Skeletal muscle proteolysis is associated with sympathetic activation and TNF-α-ubiquitin-proteasome pathway in liver cirrhotic rats.

    abstract:BACKGROUND AND AIM:This study examined the effects of adrenergic blockade on muscle wasting and expression of the ubiquitin-proteasome system, tumor necrosis factor-α (TNF-α) and its signaling pathways in skeletal muscles of cirrhotic rats. METHODS:Cirrhosis was induced by bile duct ligation in adult male Sprague-Dawl...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.13159

    authors: Lin SY,Wang YY,Chuang YH,Chen CJ

    更新日期:2016-04-01 00:00:00

  • Alcoholic liver disease: pathogenesis, management, and novel targets for therapy.

    abstract::Alcohol use is a leading cause of preventable morbidity and mortality worldwide, with much of its negative impact as the result of alcoholic liver disease (ALD). ALD is a broad term that encompasses a spectrum of phenotypes ranging from simple steatosis to steatohepatitis, progressive fibrosis, cirrhosis, and hepatoce...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/jgh.12030

    authors: Orman ES,Odena G,Bataller R

    更新日期:2013-08-01 00:00:00

  • Elevation of serum and ascites cancer antigen 125 levels in patients with liver cirrhosis.

    abstract:BACKGROUND AND AIM:Serum cancer antigen (CA) 125 elevation has been reported in patients with liver disease, but it is poorly characterized. The present study aimed to evaluate the range of serum and ascitic CA 125 levels in patients with liver cirrhosis and to explore possible factors associated with CA 125 elevation....

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.2003.03180.x

    authors: Xiao WB,Liu YL

    更新日期:2003-11-01 00:00:00

  • Cyclin E facilitates dysplastic hepatocytes to bypass G1/S checkpoint in hepatocarcinogenesis.

    abstract:BACKGROUND AND AIM:By array-comparative genomic hybridization, we demonstrated cyclin E as one of seven genes associated with hepatocellular carcinoma (HCC) development in Ku70 DNA repair-deficient mice. We therefore explored the hypothesis that during hepatocarcinogenesis, cyclin E kinase can overcome the inhibitory e...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12216

    authors: Pok S,Wen V,Shackel N,Alsop A,Pyakurel P,Fahrer A,Farrell GC,Teoh NC

    更新日期:2013-09-01 00:00:00

  • A pilot study of three-dimensional conformal radiotherapy in unresectable hepatocellular carcinoma.

    abstract:BACKGROUND:The purpose of this study was to determine the potential role of three-dimensional (3-D) conformal radiotherapy (RT) in treatment of unresectable hepatocellular carcinoma (HCC). METHODS:Thirteen patients were included in this study, which was conducted between 1993 and 1996. Nine patients (group A) were tre...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1440-1746.1999.01994.x

    authors: Cheng SH,Lin YM,Chuang VP,Yang PS,Cheng JC,Huang AT,Sung JL

    更新日期:1999-10-01 00:00:00

  • Decreased production of insulin-like growth factor-binding protein (IGFBP)-6 by transfection of colon cancer cells with an antisense IGFBP-6 cDNA construct leads to stimulation of cell proliferation.

    abstract:BACKGROUND:: Previously, we have observed that highly unsaturated dietary (n-3) fatty acids inhibit cell proliferation in conjunction with stimulation of insulin-like growth factor-binding protein (IGFBP)-6 secretion in Caco-2 cells, a human colon carcinoma cell line. METHODS:: To test the converse hypothesis that inh...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.2002.02703.x

    authors: Kim EJ,Schaffer BS,Kang YH,Macdonald RG,Park JH

    更新日期:2002-05-01 00:00:00

  • Epidemiology, risk factors, and the promotion of pancreatic cancer: role of the stellate cell.

    abstract::There are approximately 277,000 new cases of pancreatic cancer and 266,000 deaths from pancreatic cancer annually, indicating a mortality rate of 96% of the cases diagnosed. Because of the ineffectiveness of therapies, a major emphasis needs to be placed on prevention. This paper reviews the epidemiology and risk fact...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1746.2011.07013.x

    authors: Pandol S,Gukovskaya A,Edderkaoui M,Dawson D,Eibl G,Lugea A

    更新日期:2012-03-01 00:00:00

  • Peritoneal absorption of pancreatic enzymes in bile-induced acute pancreatitis in dogs.

    abstract::To clarify the contribution of peritoneal absorption of enzyme-rich exudate to the persistent elevation of serum amylase in bile-induced pancreatitis in dogs, serum amylase, lipase and immunoreactive trypsin (IRT) levels were measured during 24 h after induction of pancreatitis with and without peritoneal lavage. The ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1990.tb01429.x

    authors: Sugimoto Y,Hayakawa T,Kondo T,Shibata T,Kishimoto W

    更新日期:1990-09-01 00:00:00

  • Guidelines for the diagnosis and treatment of Helicobacter pylori infection in Korea, 2013 revised edition.

    abstract::The Korean College of Helicobacter and Upper Gastrointestinal Research first developed guidelines for the diagnosis and treatment of Helicobacter pylori (H. pylori) infection in 1998, and revised guidelines were proposed in 2009 by the same group. Although the revised guidelines were based on a comprehensive review of...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,实务指引,评审

    doi:10.1111/jgh.12607

    authors: Kim SG,Jung HK,Lee HL,Jang JY,Lee H,Kim CG,Shin WG,Shin ES,Lee YC,Korean College of Helicobacter and Upper Gastrointestinal Research.

    更新日期:2014-01-01 00:00:00

  • Effects of Helicobacter pylori eradication therapy on gastric emptying measured using the 13C-octanoic acid breath test and the acetaminophen method.

    abstract:BACKGROUND:The relationship between Helicobacter pylori eradication and gastric emptying has been reported; however, the effect of eradication therapy on gastric emptying is still unclear. This study evaluated the relationship between three gastric emptying techniques, the scintigraphic technique, the 13C-octanoic acid...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2006.04075.x

    authors: Kachi M,Shirasaka D,Aoyama N,Ebara S,Miki I,Morita Y,Tamura T,Kasuga M

    更新日期:2006-05-01 00:00:00

  • Combination and newer therapies for chronic hepatitis B.

    abstract::Worldwide the need for effective therapy for chronic hepatitis B is similar to that for chronic hepatitis C. Current licensed treatment for chronic hepatitis B (interferon (IFN)-alpha, lamivudine) does not significantly alter the natural history of the disease because the frequency of sustained response is too low; ho...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.17.s3.24.x

    authors: Schalm SW,De Man RA,Janssen HL

    更新日期:2002-12-01 00:00:00

  • Artemisia asiatica extracts protect against ethanol-induced injury in gastric mucosa of rats.

    abstract:BACKGROUND AND AIM:Based on our previous studies that Artemisia asiatica extracts exert either antioxidative or cytoprotective actions against non-steroidal anti-inflammatory drugs or Helicobacter pylori-induced gastric mucosal injury, or imposes qualified ulcer healing in an acetic acid-induced gastric ulcer model, we...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2008.05333.x

    authors: Park SW,Oh TY,Kim YS,Sim H,Park SJ,Jang EJ,Park JS,Baik HW,Hahm KB

    更新日期:2008-06-01 00:00:00

  • Indocyanine green retention test in cirrhosis and portal hypertension: Accuracy and relation to severity of disease.

    abstract:BACKGROUND AND AIMS:Patients with cirrhosis and portal hypertension often develop complications relating to hepatic excretory dysfunction. The standard measurement of the hepatic excretion is the constant infusion indocyanine green clearance (ICGCI ) technique. The ICG 15-min retention test (ICG-r15) is faster, more pa...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.14470

    authors: Møller S,la Cour Sibbesen E,Madsen JL,Bendtsen F

    更新日期:2019-06-01 00:00:00

  • Radiology of pancreatic adenocarcinoma: current status of imaging.

    abstract::Pancreatic adenocarcinoma is one of the leading causes of cancer death in the West, with a poor overall 5-year survival rate of only 4%. Late clinical presentation with an advanced disease results in a low rate of surgical intervention. Tumor serum marker CA 19-9 is sensitive, although not specific for the diagnosis o...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1746.2007.05117.x

    authors: Sahani DV,Shah ZK,Catalano OA,Boland GW,Brugge WR

    更新日期:2008-01-01 00:00:00

  • Serum hepatitis B surface antigen quantification as a useful assessment for significant fibrosis in hepatitis B e antigen-positive hepatitis B virus carriers.

    abstract:BACKGROUND AND AIMS:The role of serum quantitative hepatitis B surface antigen (qHBsAg) in identifying hepatitis B virus (HBV) carriers with significant fibrosis is unknown. This study aims to evaluate the diagnostic value of qHBsAg for hepatic fibrosis in hepatitis B e antigen (HBeAg)-positive HBV carriers. METHODS:C...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12304

    authors: Xun YH,Zang GQ,Guo JC,Yu XL,Liu H,Xiang J,Liu J,Shi JP

    更新日期:2013-11-01 00:00:00

  • Narrowband imaging with near-focus magnification for discriminating the gastric tumor margin before endoscopic resection: A prospective randomized multicenter trial.

    abstract:BACKGROUND AND AIM:This study investigated the usefulness of near-focus narrowband imaging (NF-NBI) for determining gastric tumor margins compared with indigo carmine chromoendoscopy (ICC) before endoscopic submucosal dissection (ESD). METHODS:This prospective randomized controlled trial was conducted at seven teachin...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.15109

    authors: Kim JW,Jung Y,Jang JY,Kim GH,Bang BW,Park JC,Choi HS,Cho JH,Research Group for Endoscopic Instruments and Stents of Korean Society of Gastrointestinal Endoscopy.

    更新日期:2020-11-01 00:00:00

  • Prevalence of enteric pathogens among community based asymptomatic individuals.

    abstract:BACKGROUND AND AIMS:The objective of this study was to describe the prevalence of pathogenic microorganisms in asymptomatic individuals in a community study in Melbourne, Australia. METHODS:The study population was a subset of 2803 individuals participating in the Water Quality Study; a community based randomized tria...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1440-1746.2000.02089.x

    authors: Hellard ME,Sinclair MI,Hogg GG,Fairley CK

    更新日期:2000-03-01 00:00:00

  • Ultrasound-guided fine needle aspiration biopsy of portal vein thrombosis in liver cirrhosis: results in 15 patients.

    abstract::Between 1988 and 1992 ultrasound-guided fine needle aspiration biopsies of thromboses in the main branches of the portal vein were carried out in 15 patients with liver cirrhosis. The aims of the study were to evaluate the usefulness, feasibility and diagnostic accuracy of this procedure in cirrhotics with known or su...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1995.tb01367.x

    authors: De Sio I,Castellano L,Calandra M,Romano M,Persico M,Del Vecchio-Blanco C

    更新日期:1995-11-01 00:00:00

  • Novel endoscopic categorization for prediction of chemoradiotherapy response in locally advanced esophageal cancer.

    abstract:BACKGROUND AND AIM:Preoperative chemoradiotherapy (CRT) followed by esophagectomy is a well-known treatment modality for patients with locally advanced esophageal cancer (EC). This study developed an algorithm to predict pathological complete response (CR) in these patients using post-CRT endoscopic category with biops...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.14055

    authors: Cho CJ,Kang HJ,Park SJ,Kim GH,Park SH,Eo SH,Kim MJ,Kim YH,Park SR,Kim JH,Ahn JY,Kim DH,Choi KD,Song HJ,Jung HY,Park YS,Lee GH

    更新日期:2018-06-01 00:00:00

  • Flow cytometric analysis of cell proliferation kinetics during duodenal ulcer healing.

    abstract::Cell proliferation in the gastroduodenal mucosa of patients with duodenal ulcers was evaluated using flow cytometry. Forty patients with duodenal ulcers and 12 normal subjects were investigated. Biopsy samples were obtained during endoscopic examination and subjected to DNA analysis by flow cytometry. Thirty patients ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1998.tb00649.x

    authors: Kobayashi I,Kawano S,Tsuji S,Nakama A,Sawaoka H,Masuda E,Nagano K,Fusamoto H,Kamada T

    更新日期:1998-04-01 00:00:00

  • Rise and fall of peptic ulceration: A disease of civilization?

    abstract::Humans and Helicobacter pylori have evolved and adapted over tens of thousands of years. Yet peptic ulcer disease appeared to be rare prior to the 19th century. The prevalence of peptic ulcer disease increased between 1850 and 1900 and culminated in a cohort at high risk that was born at the end of the 19th century. T...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 历史文章,杂志文章,评审

    doi:10.1111/jgh.14090

    authors: Roberts-Thomson IC

    更新日期:2018-07-01 00:00:00

  • Histological evaluation of intracapsular venous invasion for discrimination between portal and hepatic venous invasion in hepatocellular carcinoma.

    abstract:BACKGROUND AND AIM:Histological criteria for intracapsular venous invasion (IVI) that would allow its discrimination between portal and hepatic venous invasion in hepatocellular carcinoma (HCC) have not been established. METHODS:We evaluated IVI immunohistochemically to discriminate between portal and hepatic venous i...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2009.06008.x

    authors: Ohashi M,Wakai T,Korita PV,Ajioka Y,Shirai Y,Hatakeyama K

    更新日期:2010-01-01 00:00:00