Rickets and osteopetrosis: the osteosclerotic (oc) mouse.

Abstract:

:A new mouse osteopetrotic mutation, osteosclerosis, has been examined with respect to rickets. These osteopetrotic mice were hypocalcemic and hypophosphatemic, and had greatly thickened epiphyseal plates with abnormalities in matrix vesicles when compared with normal littermates. Such biochemic and morphologic manifestations of rickets in this osteopetrotic mutation may explain the failure of osteosclerotic mice to be cured by transplantation of bone marrow from normal littermates and indicate that vitamin D metabolism and matrix vesicle biochemistry warrant further study.

journal_name

Clin Orthop Relat Res

authors

Banco R,Seifert MF,Marks SC Jr,McGuire JL

subject

Has Abstract

pub_date

1985-12-01 00:00:00

pages

238-46

issue

201

eissn

0009-921X

issn

1528-1132

pub_type

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