Abstract：
:The covalent affinity probe maltosyl isothiocyanate (MITC) has been used previously to identify the glucose transporter of human erythrocytes as a component of band 3. By use of limited proteolysis, the site on the Mr 100 000 protein to which MITC attaches has been localized to a 17 000-dalton region near the center of the polypeptide chain which is intimately associated with the membrane. The erythrocyte anion transporter, which is probably homologous to the glucose carrier, has a corresponding segment which is known to bind the covalent affinity label 4,4'-diisothiocyano-2,2'-stilbenedisulfonic acid [Ramjeesingh, M., Gaarn, A., & Rothstein, A. (1980) Biochim. Biophys. Acta 559, 127-139]. These results suggest that, in addition to having structural features in common, the two carrier proteins may be quite similar with regard to functional organization.
journal_name
Biochemistryjournal_title
Biochemistryauthors
Shelton RL Jr,Langdon RGdoi
10.1021/bi00331a001subject
Has Abstractpub_date
1985-05-07 00:00:00pages
2397-400issue
10eissn
0006-2960issn
1520-4995journal_volume
24pub_type
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