Abstract:
:In a study designed to assess the relationship between a dichotomous exposure and the eventual occurrence of a dichotomous outcome, frequency matching has been proposed as a way to balance the exposure cohorts with respect to the sampling distribution of potential confounding factors. This paper discusses the pooled estimator for the log relative risk, and provides an estimator for its variance which takes into account the dependency in the pooled outcomes induced by frequency matching. The pooled estimator has asymptotic relative efficiency less than but close to 1, relative to the usual, inverse variance weighted, stratified estimator. Simulations suggest, however, that the pooled estimator is likely to outperform the stratified estimator when samples are of moderate size. This estimator carries the added advantage that it consistently estimates a meaningful population parameter under heterogeneity of the relative risk across strata.
journal_name
Biometricsjournal_title
Biometricsauthors
Weinberg CRsubject
Has Abstractpub_date
1985-03-01 00:00:00pages
117-27issue
1eissn
0006-341Xissn
1541-0420journal_volume
41pub_type
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