Abstract:
:5-Substituted-2,2'-anhydrouridines are a new class of competitive inhibitors of uridine phosphorylase. The most potent member of the series is 2,2'-anhydro-5-ethyluridine with an apparent Ki value of 25 nM. These compounds are selective inhibitors of uridine phosphorylase and have no effect on thymidine phosphorylase. 5-Substituted-2,2'-anhydrouridines are no substrates of either uridine phosphorylase or thymidine phosphorylase.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
Veres Z,Szabolcs A,Szinai I,Dénes G,Kajtár-Peredy M,Otvös Ldoi
10.1016/0006-2952(85)90643-4subject
Has Abstractpub_date
1985-05-15 00:00:00pages
1737-40issue
10eissn
0006-2952issn
1873-2968pii
0006-2952(85)90643-4journal_volume
34pub_type
杂志文章abstract::The homomeric α7 nicotinic acetylcholine receptor is a well-studied therapeutic target, though its characteristically rapid desensitization complicates the development of drugs with specific agonist effects. Moreover, some experimental compounds such as GTS-21 (2,4diMeOBA), a derivative of the α7-selective partial ago...
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/0006-2952(91)90563-k
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pub_type: 杂志文章
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/0006-2952(89)90628-x
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Biochemical pharmacology
pub_type: 杂志文章,评审
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更新日期:2014-05-15 00:00:00
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pub_type: 杂志文章
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更新日期:1991-03-01 00:00:00
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pub_type: 杂志文章
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/s0006-2952(02)01190-5
更新日期:2002-08-01 00:00:00
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更新日期:2001-07-15 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/0006-2952(85)90208-4
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
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更新日期:1983-03-15 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
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更新日期:1982-02-01 00:00:00
abstract:UNLABELLED:ZD1839 ("Iressa"), a selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), is currently undergoing preclinical and clinical evaluation in several solid tumors. The present study aimed to assess the effect of ZD1839 in combination with oxaliplatin in the colon cancer cell lines HT-2...
journal_title:Biochemical pharmacology
pub_type: 杂志文章
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更新日期:2003-08-15 00:00:00
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更新日期:2010-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:1989-05-15 00:00:00
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pub_type: 杂志文章
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更新日期:1990-06-15 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
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更新日期:1985-12-15 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
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更新日期:1993-12-03 00:00:00
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pub_type: 杂志文章
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更新日期:2003-10-01 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
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更新日期:2005-11-15 00:00:00