5-Substituted-2,2'-anhydrouridines, potent inhibitors of uridine phosphorylase.

Abstract:

:5-Substituted-2,2'-anhydrouridines are a new class of competitive inhibitors of uridine phosphorylase. The most potent member of the series is 2,2'-anhydro-5-ethyluridine with an apparent Ki value of 25 nM. These compounds are selective inhibitors of uridine phosphorylase and have no effect on thymidine phosphorylase. 5-Substituted-2,2'-anhydrouridines are no substrates of either uridine phosphorylase or thymidine phosphorylase.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Veres Z,Szabolcs A,Szinai I,Dénes G,Kajtár-Peredy M,Otvös L

doi

10.1016/0006-2952(85)90643-4

subject

Has Abstract

pub_date

1985-05-15 00:00:00

pages

1737-40

issue

10

eissn

0006-2952

issn

1873-2968

pii

0006-2952(85)90643-4

journal_volume

34

pub_type

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