Abstract:
:5-Substituted-2,2'-anhydrouridines are a new class of competitive inhibitors of uridine phosphorylase. The most potent member of the series is 2,2'-anhydro-5-ethyluridine with an apparent Ki value of 25 nM. These compounds are selective inhibitors of uridine phosphorylase and have no effect on thymidine phosphorylase. 5-Substituted-2,2'-anhydrouridines are no substrates of either uridine phosphorylase or thymidine phosphorylase.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
Veres Z,Szabolcs A,Szinai I,Dénes G,Kajtár-Peredy M,Otvös Ldoi
10.1016/0006-2952(85)90643-4subject
Has Abstractpub_date
1985-05-15 00:00:00pages
1737-40issue
10eissn
0006-2952issn
1873-2968pii
0006-2952(85)90643-4journal_volume
34pub_type
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