Abstract:
:The validity of the membrane hypothesis of aging (Zs.-Nagy, 1978) was tested on identified giant neurons of the snail Lymnaea stagnalis L. by using a combination of intracellular microelectrophysiology and X-ray microanalysis of the intracellular water and electrolyte concentrations on the very same cells. The snails were taken from an inbred stock and divided into young, adult and old age groups (3, 12 and 24 mth, respectively). The giant neuron called LPa-2 from the left parietal ganglion was selected for the studies. The resting potential of the cell membrane was recorded by means of intracellular microelectrode technique. The very same cells were then explored by freeze fracture and analyzed by an energy dispersive bulk specimen method of X-ray microanalysis. The resting membrane potential displayed an age-dependent hyperpolarization, the intracellular water content decreased considerably and the intracellular potassium concentration increased almost 90% by old age. The relative passive permeability ratio for potassium (PK) and chloride (PCl) was calculated from the measured data by means of the Goldman-Hodgkin-Katz equation. Such calculations revealed that PK decreases nearly 50% with age causing the increase of the intracellular potassium content, and this is accompanied also by a significant decrease of the PCl. The results support the validity of the membrane hypothesis of aging and are in agreement with the general knowledge regarding the electrophysiological behaviour of the giant neurons of Gastropode snails.
journal_name
Arch Gerontol Geriatrjournal_title
Archives of gerontology and geriatricsauthors
Nagy I,Tóth S,Lustyik Gdoi
10.1016/0167-4943(85)90018-4subject
Has Abstractpub_date
1985-04-01 00:00:00pages
53-66issue
1eissn
0167-4943issn
1872-6976pii
0167-4943(85)90018-4journal_volume
4pub_type
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journal_title:Archives of gerontology and geriatrics
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journal_title:Archives of gerontology and geriatrics
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doi:10.1016/0167-4943(86)90030-0
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