当前位置： SCI文献检索 > ARCHIVES OF GERONTOLOGY AND GERIATRICS期刊下所有文献 > Leg edema, ST-T abnormalities, and high BNP values are important signs of heart failure in the elderly.

Leg edema, ST-T abnormalities, and high BNP values are important signs of heart failure in the elderly.

Abstract：

:This study was aimed at the mechanism of the circulatory failure characteristic of the elderly through elucidating the cause of leg edema frequently found in patients under treatment in health care facilities for physical or mental handicaps. ECG and measurement of atrial (ANP) and brain (BNP) natriuretic peptides were carried out on 156 patients (mostly females aged 84 years on average) and echocardiographic assessment was done on 44 patients. Non-specific ST-T abnormalities were frequently found in patients with moderate or severe leg edema (61 vs. 37% in those with slight or no edema). BNP levels were markedly increased in patients with either leg edema or ECG abnormalities (Group B) and with both (Group C) compared with those without either (Group A), with averages of 35.5+/-23.9, 91.3+/-80.1, and 184.3+/-139.0 pg/ml, respectively, for Group A, B, and C. UCG examination revealed marked regurgitation of cardiac valves, more frequently in patients with BNP over 50 pg/ml than in those with less (14/24 vs. 2/20), with a difference in extent of 5.7 versus 1.6 on an arbitrary scale. In addition to left ventricular hypertrophy, dilatation of the left atrium and inferior vena cava was frequently observed in patients with higher BNP levels. It is concluded that both cardiac valve regurgitation and myocardial damage represented by ST-T abnormalities on ECG result in heart failure characteristic of the elderly, and that an increase in BNP is an important sign of such heart failure.

journal_name

Arch Gerontol Geriatr

journal_title

Archives of gerontology and geriatrics

authors

Yamamoto A,Mankumo M,Kawaguchi A,Nishizawa H,Toyoshima H,Kangawa K

doi

10.1016/s0167-4943(01)00098-x

subject

Has Abstract

pub_date

2001-08-01 00:00:00

pages

37-52

issue

1

eissn

0167-4943

issn

1872-6976

pii

S0167-4943(01)00098-X

journal_volume

33

pub_type

杂志文章

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