Abstract：
:A model for radiation-induced cross-linking of DNA and proteins has been developed. It is based on initial formation of free radicals on a DNA base, i.e., thymine, and on an amino acid, i.e., tyrosine. It was demonstrated that interaction of these radicals is highly favored as measured by their kinetics and the cross-linked products. The gas chromatography-mass spectrometry methodology used for the identification of the thymine-tyrosine cross-links is suggested as an experimental approach in the measurements of biological cross-links.
journal_name
Biochemistryjournal_title
Biochemistryauthors
Simic MG,Dizdaroglu Mdoi
10.1021/bi00322a034subject
Has Abstractpub_date
1985-01-01 00:00:00pages
233-6issue
1eissn
0006-2960issn
1520-4995journal_volume
24pub_type
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