Medical therapy of hypothalamic diseases.

Abstract:

:Hormonal disturbances caused by hypothalamic pathology can be treated effectively by target hormone replacement in the case of failure of glandotropic hormone secretion. Hyposomatotropism in children has to be substituted by parenteral administration of growth hormone. In addition gonadotropins respectively gonadotropin releasing factor have to be given in order to restore fertility in hypothalamic hypogonadism. Posterior pituitary failure can be adequately replaced by administration of analogues of antidiuretic hormone. Hypothalamic pathology causing hypersecretion of anterior pituitary hormones may also be accessable to medical treatment. This pertains particularly to hyperprolactinemia and precocious puberty. However, there is no medical therapy so far for hypothalamic disturbances leading to veterative dysfunction like disturbances of temperature regulation and control of thirst and polyphagia. In this situation symptomatic correction of the abnormality represents the only possibility to keep these patients alive.

journal_name

Acta Neurochir (Wien)

journal_title

Acta neurochirurgica

authors

von Werder K,Müller OA

doi

10.1007/BF01406335

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

147-51

issue

1-4

eissn

0001-6268

issn

0942-0940

journal_volume

75

pub_type

杂志文章
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