The solubilization of platelet membrane-bound acetylcholinesterase and aryl acylamidase by exogenous or endogenous phosphatidylinositol specific phospholipase C.

abstract：:In the present study, a novel synthetic compound 4-(2-(cyclohex-2-enylidene)hydrazinyl)quinolin-2(1H)-one (CYL-4d) was found to inhibit lipopolysaccharide (LPS)-induced nitric oxide (NO) production without affecting cell viability or enzyme activity of expressed inducible NO synthase (iNOS) in RAW 264.7 macrophages. C...

journal_title：Biochemical pharmacology

authors： Lin MW,Tsao LT,Chang LC,Chen YL,Huang LJ,Kuo SC,Tzeng CC,Lee MR,Wang JP

更新日期：2007-06-01 00:00:00

abstract：:Recently, accumulated statistical data indicate the protective effect of caffeine consumption against several types of cancer diseases. There are also reports about protective effect of caffeine and other xanthines against tumors induced by polycyclic aromatic hydrocarbons. One of the explanations is based on biologic...

journal_title：Biochemical pharmacology

authors： Kapuscinski J,Ardelt B,Piosik J,Zdunek M,Darzynkiewicz Z

更新日期：2002-02-15 00:00:00

abstract：:Cardioprotective effect of a free radical-scavenging compound (HO-3073) was examined during ischaemia-reperfusion (IR) in isolated heart perfusion system and its influence on the pro-survival Akt signalling pathway was addressed. Rat hearts were perfused according to the Langendorff method and subjected to a global 25...

journal_title：Biochemical pharmacology

authors： Toth A,Kovacs K,Deres P,Halmosi R,Czopf L,Hanto K,Kalai T,Hideg K,Sumegi B,Toth K

更新日期：2003-12-01 00:00:00

abstract：:The inhibition of rat liver monoamine oxidase by a number of N-propargyl and alpha-methyl amine derivatives has been examined. The results indicate that alpha-methyl-substituted primary and secondary amine derivatives tend to show selectivity as reversible inhibitors towards the A-form of the enzyme. The structural fe...

journal_title：Biochemical pharmacology

authors： Tipton KF,McCrodden JM,Kalir AS,Youdim MB

更新日期：1982-04-01 00:00:00

abstract：:In congenital jaundice, which is due to defects of bilirubin gluruconidation, bilirubin is degraded by an alternative pathway into unidentified products. Previously, it was shown that plasma bilirubin levels can be decreased in rats with this defect by inducers of CYP1A enzymes. Here, liver microsomes from rats or mic...

journal_title：Biochemical pharmacology

authors： Zaccaro C,Sweitzer S,Pipino S,Gorman N,Sinclair PR,Sinclair JF,Nebert DW,De Matteis F

更新日期：2001-04-01 00:00:00

abstract：:By means of Sephadex G-75 and CM-Sephadex C-50 column chromatography and reverse-phase HPLC, a low molecular weight (Mr = 7500), cysteine-rich peptide, halysin, was purified from Agkistrodon halys (mamushi) snake venom. Halysin is a potent platelet aggregation inhibitor that concentration-dependently inhibited human p...

journal_title：Biochemical pharmacology

authors： Huang TF,Liu CZ,Ouyang CH,Teng CM

更新日期：1991-08-22 00:00:00

abstract：:Minoxidil sulphotransferase (MST) activity was determined in the cytosolic fraction of rat skin and liver. MST of rat skin is similar to the P (phenol)-form of phenosulphotransferase (PST) of human tissues with respect to thermostability and inhibition by 2,6-dichloro-4-nitrophenol (DCNP). p-Nitrophenol, a prototype s...

journal_title：Biochemical pharmacology

authors： Wong KO,Tan AY,Lim BG,Wong KP

更新日期：1993-03-09 00:00:00

abstract：:Free radical-induced damage to lipid and protein constituents of neuronal membranes contributes to the pathophysiology of neurodegenerative diseases, including Alzheimer's disease (AD). The development of an effective inhibitor of oxidative stress represents an important goal for the treatment of AD. In this study, th...

journal_title：Biochemical pharmacology

authors： Mason RP,Olmstead EG,Jacob RF

更新日期：2000-09-01 00:00:00

abstract：:An enzyme (NADPH-dependent diaphorase) present in rat brain microsomes has been solubilised and shown to utilise both nitrobluetetrazolium and cytochrome c as electron acceptors, when reduced by NADPH. The kinetics of the enzyme have been determined using cytochrome c (Km = 1.3 microM), NADPH (Km = 1.4 microM) and the...

journal_title：Biochemical pharmacology

authors： Kemp MC,Kuonen DR,Sutton A,Roberts PJ

更新日期：1988-08-15 00:00:00

abstract：:The effects of physiological and pathological concentrations of glucocorticoids were investigated using the glucocorticoid antagonist RU486 and the synthetic glucocorticoid dexamethasone, respectively. The effects of these treatments on the concentrations of glutamine and other amino acids in skeletal muscle and plasm...

journal_title：Biochemical pharmacology

authors： Parry-Billings M,Leighton B,Dimitriadis GD,Bond J,Newsholme EA

更新日期：1990-09-01 00:00:00

abstract：:Diabetic nephropathy (DN) is one of the most prevalent lethal complications of diabetes that leads to end stage renal disease. Although several clinical approaches exist to attenuate DN, there is not curative treatment to date. DN is complicated, as it involves several simultaneous molecular pathways. Some natural and...

journal_title：Biochemical pharmacology

authors： Dewanjee S,Bhattacharjee N

更新日期：2018-09-01 00:00:00

abstract：:The β2-adrenergic receptor (β2AR) is the prototypical member of the heptahelical G protein-coupled receptor (GPCR) superfamily and is well-known to elicit biological effects through both G protein-dependent and G protein-independent signaling cascades. Agonism of β2AR has been described to promote phosphorylation and ...

journal_title：Biochemical pharmacology

authors： Singh M,Moniri NH

更新日期：2012-09-01 00:00:00

abstract：:Adenosine is an endogenous agent exerting potent action on the immune system including regulation of lymphocyte functioning. Impaired T lymphocyte functioning is a common feature of diabetes. The aims of this study were to examine the effects of glucose and insulin on nucleoside transporters (NT) expression level and ...

journal_title：Biochemical pharmacology

authors： Sakowicz M,Szutowicz A,Pawelczyk T

更新日期：2004-10-01 00:00:00

abstract：:Incorporation of thia fatty acids and their effects on the fatty acid composition in phospholipids has been investigated in 7800 C1 hepatoma cells and cultured hepatocytes. 3-Thia fatty acids of chain lengths from dodecyl-to hexadecyl-thioacetic acid were incorporated into phospholipids during a 3-day incubation. Long...

journal_title：Biochemical pharmacology

authors： Wu P,Grav HJ,Horn R,Bremer J

更新日期：1996-03-22 00:00:00

abstract：:The biotransformation and the hepato- and nephrotoxicity of the mercapturic acids (N-acetyl-1-cysteine S-conjugates) of three structurally related 2,2-difluoroethylenes were investigated in vivo in the rat. All mercapturic acids appeared to cause nephrotoxicity, without any measureable effect on the liver. The mercapt...

journal_title：Biochemical pharmacology

authors： Commandeur JN,Brakenhoff JP,De Kanter FJ,Vermeulen NP

更新日期：1988-12-01 00:00:00

abstract：:To study the effect of sex hormones and alcohol on the hepatic activities of alcohol metabolizing enzymes, estradiol or testosterone were administered for 4 weeks to ovarectomized or sham operated adult female rats pair-fed nutritionally adequate liquid diets containing either alcohol (36% of total calories) or isocal...

journal_title：Biochemical pharmacology

authors： Teschke R,Wannagat FJ,Löwendorf F,Strohmeyer G

更新日期：1986-02-01 00:00:00

abstract：:The antidepressants milnacipran and paroxetine are used clinically worldwide. In the present study, we report here the effects of treatment with milnacipran and paroxetine on the functional activity, binding sites, and mRNA of the norepinephrine (NE) transporter (NET) in cultured bovine adrenal medullary cells. In acu...

journal_title：Biochemical pharmacology

authors： Shinkai K,Yoshimura R,Toyohira Y,Ueno S,Tsutsui M,Nakamura J,Yanagihara N

更新日期：2005-11-01 00:00:00

abstract：:L1210 and K562 leukaemic cells have been used to study the relationship between cytotoxicity and free radical production by two aziridinyl benzoquinones, 2,5-bis(carboethoxyamino)3,6-diaziridinyl-1,4-benzoquinone (AZQ) and 2,5-bis(2-hydroxyethylamino)-3,6-diaziridinyl-1,4-benzoquinone (BZQ). BZQ showed a high level of...

journal_title：Biochemical pharmacology

authors： Lea JS,Garner HJ,Butler J,Hoey BM,Ward TH

更新日期：1988-05-15 00:00:00

abstract：:Metabolic and cardiovascular disease patients have increased plasma levels of lipids and, specifically, of palmitate, which can be toxic for several tissues. Trimetazidine (TMZ), a partial inhibitor of lipid oxidation, has been proposed as a metabolic modulator for several cardiovascular pathologies. However, its mech...

journal_title：Biochemical pharmacology

authors： Kuzmicic J,Parra V,Verdejo HE,López-Crisosto C,Chiong M,García L,Jensen MD,Bernlohr DA,Castro PF,Lavandero S

更新日期：2014-10-01 00:00:00

abstract：:Resealed synaptic plasma membrane vesicles exhibit Na+-dependent Ca2+ transport activity which may participate in regulation of free Ca2+ concentrations in nerve endings. Sodium chloride-loaded vesicles took up Ca2+ from the external medium (150 mM KCl-25 mM Tris/HCl) in the presence of an outward-directed Na+ gradien...

journal_title：Biochemical pharmacology

authors： Michaelis ML,Michaelis EK

更新日期：1983-03-15 00:00:00

abstract：:An Ehrlich ascites tumour cell line (EHR2) was selected for resistance to etoposide (VP16) by in vivo exposure to this agent. The resulting cell line (EHR2/VP16) was 114.3-, 5.7-, and 4.0-fold resistant to VP16, daunorubicin, and vincristine, respectively. The amount of salt-extractable immunoreactive topoisomerase II...

journal_title：Biochemical pharmacology

authors： Nielsen D,Maare C,Eriksen J,Litman T,Friche E,Skovsgaard T

更新日期：2000-08-01 00:00:00

abstract：:The distribution of renal adenosine A(1) receptors was investigated in rats with glycerol- or mercuric chloride (HgCl(2))-induced acute renal failure. Receptors were localised by autoradiography using [(3)H]8-cyclopentyl-1,3-dipropylxanthine ([(3)H]DPCPX), a selective A(1) adenosine receptor antagonist. In saline-inje...

journal_title：Biochemical pharmacology

authors： Smith JA,Whitaker EM,Bowmer CJ,Yates MS

更新日期：2000-03-15 00:00:00

abstract：:The response of an SV40-immortalized hepatocyte cell line (CWSV-1) derived from adult male rat hepatocytes to human growth hormone (hGH) was investigated. CWSV-1 cells, which have been characterized extensively, retain certain differentiated functions of normal liver (Woodworth and Isom, Mol Cell Biol 7: 3740-3748, 19...

journal_title：Biochemical pharmacology

authors： Kempe KC,Isom HC,Greene FE

更新日期：1995-04-18 00:00:00

abstract：:Mastoparan, a polypeptide known to activate heterotrimeric GTP-binding proteins, enhances the transport of Ca2+ and K+ across membranes. In the present study we investigated the influence of mastoparan on transepithelial resistance (TER) and on short circuit current (SCC) of the intestinal cell line T84. Mastoparan de...

journal_title：Biochemical pharmacology

authors： Blumenstein I,Gerhard R,Ries J,Kottra G,Stein J

更新日期：2003-04-01 00:00:00

abstract：:Extracellular ATP suppressed the growth of HL-60 leukemia cells and induced their differentiation as revealed by N-formyl-methionyl-leucyl-phenylalanine-induced beta-glucuronidase release. ATP degraded to ADP, AMP, and adenosine, and the effect of ATP on cell growth was mimicked by these metabolites added to the cultu...

journal_title：Biochemical pharmacology

authors： Conigrave AD,van der Weyden L,Holt L,Jiang L,Wilson P,Christopherson RI,Morris MB

更新日期：2000-12-01 00:00:00

abstract：:Store-dependent calcium entry represents a little characterized calcium permeation pathway that is present in a variety of cell types. It is activated in an unknown way by depletion of intracellular calcium stores, for example in the course of phospholipase C stimulation. Current hypotheses propose that depleted calci...

journal_title：Biochemical pharmacology

authors： Bode HP,Netter KJ

更新日期：1996-04-26 00:00:00

abstract：:The current obesity epidemic is a major worldwide health and economic burden. In the modern environment, an increase in the intake of high-fat and high-sugar foods plays a crucial role in the development of obesity by disrupting the mechanisms governing food intake and energy balance. Food intake and whole-body energy...

journal_title：Biochemical pharmacology

authors： Zagmutt S,Mera P,Soler-Vázquez MC,Herrero L,Serra D

更新日期：2018-09-01 00:00:00

abstract：:The serine esterase inhibitor diisopropyl fluorophosphate (DFP) had been reported previously to inhibit IgE-dependent histamine release. Recently, it has been demonstrated that lower concentrations of DFP enhance IgE-dependent histamine release and inhibit desensitization. This manuscript describes the abilities of se...

journal_title：Biochemical pharmacology

authors： Meier HL,Gross CL,Papirmeister B

更新日期：1986-12-01 00:00:00

abstract：:Adult hepatocytes from rat and man were maintained for 2 weeks between two gel layers in a sandwich configuration to study the influence of this culture technique on the preservation of basal activities of xenobiotic-metabolizing phase I and phase II enzymes. The response of these enzyme activities to an enzyme induce...

journal_title：Biochemical pharmacology

authors： Kern A,Bader A,Pichlmayr R,Sewing KF

更新日期：1997-10-01 00:00:00

abstract：:Diabetic retinopathy (DR) is the most frequent complication of diabetes and one of leading causes of blindness worldwide. Early phases of DR are characterized by retinal pericyte loss mainly related to concurrent inflammatory process. Recently, an important link between P2X7 receptor (P2X7R) and inflammation has been ...

journal_title：Biochemical pharmacology

authors： Platania CBM,Giurdanella G,Di Paola L,Leggio GM,Drago F,Salomone S,Bucolo C

更新日期：2017-08-15 00:00:00