Abstract:
:Structural insight into DNA quadruplex structures formed by oligodeoxyribonucleotides 3'TG5'-5'GGGT3' (QS55) and 5'TG3'-3'GGGT5' (QS33) is presented. NMR analysis reveals that QS33 forms a parallel-like four-fold symmetric quadruplex, while QS55 possesses a two-fold symmetry and is characterized by a tetrameric antiparallel quadruplex embedded between two parallel tracts. The results reported here describe unprecedented quadruplex complexes provided by peculiar structural features never reported to date. These structures might inspire the design of new aptameric nucleic acids characterized by novel structural motifs hardly realizable with unmodified DNA/RNA.
journal_name
Mol Biosystjournal_title
Molecular bioSystemsauthors
Galeone A,Mayol L,Virgilio A,Virno A,Randazzo Adoi
10.1039/b718778esubject
Has Abstractpub_date
2008-05-01 00:00:00pages
426-30issue
5eissn
1742-206Xissn
1742-2051journal_volume
4pub_type
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