Multidimensional system biology: genetic markers and proteomic biomarkers of adverse pregnancy outcome in preterm birth.

Abstract:

:Premature birth before 37 weeks of gestation is a significant public health problem. Each year, 4.5 million premature infants are born worldwide. Despite extensive research and a variety of interventions, the rate of preterm birth has steadily increased over the past 20 years and reached a high of 12.8% in 2006. The etiology of most preterm births remains elusive and is likely multifactorial, with many pathophysiological pathways involved, such as excessive stretching, oxidative stress, decidual hemorrhage, and infection. Genomics and proteomics have emerged to provide a better comprehension of the pathophysiological conditions leading to preterm birth, thereby providing a perspective for improving neonatal outcome.

journal_name

Am J Perinatol

authors

Buhimschi CS,Rosenberg VA,Dulay AT,Thung S,Sfakianaki AK,Bahtiyar MO,Buhimschi IA

doi

10.1055/s-2008-1061497

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

175-87

issue

3

eissn

0735-1631

issn

1098-8785

journal_volume

25

pub_type

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