Miconazole therapy for systemic candidiasis in a conjoined (Siamese) twin and a premature newborn.

Abstract:

:A 2.5 kg thoracopagus (Siamese) twin and a 0.73 kg premature newborn developed systemic candidiasis and were treated with intravenous miconazole. The conjoined twin was in a state of severe metabolic acidosis, respiratory distress, jaundice, anuria, abdominal distension, and shock. The 0.73 kg premature infant was also in a state of severe metabolic acidosis, respiratory distress, and oliguria. Miconazole was used in this desperate situation for the treatment of life-threatening candidiasis. Both infants responded well to treatment and recovered. All parameters of their diseases improved during therapy despite pre-existing multiple organ dysfunction. Miconazole can be a safe alternative to amphotericin B for the treatment of systemic candidiasis in neonatal infants, including those with impaired renal function.

journal_name

Am J Surg

authors

Sung JP,Rajani K,Chopra DR,Grendahl JG,Haws EB

doi

10.1016/0002-9610(79)90349-0

subject

Has Abstract

pub_date

1979-11-01 00:00:00

pages

688-91

issue

5

eissn

0002-9610

issn

1879-1883

pii

0002-9610(79)90349-0

journal_volume

138

pub_type

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