当前位置： SCI文献检索 > BRITISH JOURNAL OF HAEMATOLOGY期刊下所有文献 > Characterization of blast cells in chronic granulocytic leukaemia in transformation, acute myelofibrosis and undifferentiated leukaemia. I. Ultrastructural morphology and cytochemistry.

Characterization of blast cells in chronic granulocytic leukaemia in transformation, acute myelofibrosis and undifferentiated leukaemia. I. Ultrastructural morphology and cytochemistry.

Abstract：

:A systematic analysis of the blast cell population was carried out on samples from 50 patients suffering from blast transformation of chronic granulocytic leukaemia (CGL) (31) and of myelofibrosis (4), acute myelofibrosis (AM) (11) and undifferentiated acute leukaemia (4). Transmission electron microscopy (TEM), used in 41 samples, included: morphology and techniques for myeloperoxidase (MPO), platelet-peroxidase (PPO) and acid phosphatase (AP). The majority of cases were also studied by light microscopy cytochemistry and with a battery of cell markers which are reported in the accompanying paper (San Miguel et al, 1985). The characterization of the type(s) of proliferating blasts was made from the integration of ultrastructural and immunological data. TEM morphology allowed the precise recognition of specific granules in basophil and mast-cell precursors and of ferritin particles in blasts of erythroid lineage; these rare cell types were not adequately characterized by other methods. The PPO reaction made possible the identification of pure megakaryoblastic proliferations in 38% of cases, including eight of the 11 with AM; megakaryoblasts were also present in nine of 12 cases with mixed blast cell types. The MPO and AP reactions were useful for the characterization of myeloblasts and monoblasts, respectively. Lymphoblasts could be distinguished from other cell types by TEM morphology and negative MPO and PPO reactions. TEM techniques were valuable for diagnosing correctly the type of blast cell in this study in which only four cases (8%) remained unclassifiable.

journal_name

Br J Haematol

journal_title

British journal of haematology

authors

Polli N,O'Brien M,Tavares de Castro J,Matutes E,San Miguel JF,Catovsky D

doi

10.1111/j.1365-2141.1985.tb02994.x

subject

Has Abstract

pub_date

1985-02-01 00:00:00

pages

277-96

issue

2

eissn

0007-1048

issn

1365-2141

journal_volume

59

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF HAEMATOLOGY文献大全
  • Haemostatic and rheological factors in intermittent claudication: the influence of smoking and extent of arterial disease.

    abstract：:Patients with intermittent claudication have been reported to have disturbances in blood rheology and haemostasis. Whether these disturbances are a result of, or largely independent of, smoking history and arterial narrowing has not yet been established. The levels of whole blood and plasma viscosity, haematocrit, von...

    journal_title：British journal of haematology

    pub_type： 临床试验,杂志文章

    doi：10.1046/j.1365-2141.1996.00283.x

    authors： Lee AJ,Fowkes FG,Rattray A,Rumley A,Lowe GD

    更新日期：1996-01-01 00:00:00

  • Molecular characterization of a normal Hb A2 beta-thalassaemia determinant in a Sardinian family.

    abstract：:In this study we have carried out haplotype analysis at the beta-globin gene cluster and defined the beta-thalassaemia mutations in a large Sardinian family, ascertained through a proband with thalassaemia major, in which several members were carriers of a beta-thalassaemia allele characterized by microcytosis, hypoch...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1987.tb02331.x

    authors： Oggiano L,Pirastu M,Moi P,Longinotti M,Perseu L,Cao A

    更新日期：1987-10-01 00:00:00

  • Haemophilia B Leyden arising de novo by point mutation in the putative factor IX promoter region.

    abstract：:Haemophilia B Leyden is characterized by severe factor IX deficiency during childhood with partial resolution at puberty or following the administration of anabolic steroids. The disorder has recently been associated with point mutations in the putative factor IX promoter region, which contains an imperfect direct rep...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1991.tb07976.x

    authors： Royle G,Van de Water NS,Berry E,Ockelford PA,Browett PJ

    更新日期：1991-02-01 00:00:00

  • Acute promyelocytic leukaemia in a patient treated with etoposide for Langerhans cell histiocytosis.

    abstract：:We report a child with acute promyelocytic leukaemia (APL) who was treated with etoposide (VP16) for Langerhans cell histiocytosis (LCH). A 3-year-old Japanese girl was diagnosed as having LCH. She was treated with combination chemotherapy using VP16 and prednisolone. 56 months after beginning the chemotherapy she dev...

    journal_title：British journal of haematology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2141.1994.tb04851.x

    authors： Matsuzaki A,Inamitsu T,Watanabe T,Ohga S,Ishii E,Nagotoshi Y,Tasaka H,Suda M,Ueda K

    更新日期：1994-04-01 00:00:00

  • A novel immunogenic CS1-specific peptide inducing antigen-specific cytotoxic T lymphocytes targeting multiple myeloma.

    abstract：:The CS1 antigen provides a unique target for the development of an immunotherapeutic strategy to treat patients with multiple myeloma (MM). This study aimed to identify HLA-A2(+) immunogenic peptides from the CS1 antigen, which induce peptide-specific cytotoxic T lymphocytes (CTL) against HLA-A2(+) MM cells. We iden...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.2012.09111.x

    authors： Bae J,Song W,Smith R,Daley J,Tai YT,Anderson KC,Munshi NC

    更新日期：2012-06-01 00:00:00

  • Dissociation between fibrinogen and fibrin interaction with platelets in patients with different subtypes of Glanzmann's thrombasthenia: studies in an ex vivo perfusion chamber model.

    abstract：:To explore the possible role of a residual or variant alphaIIbbeta3 integrin (alphaIIbbeta3) in thrombogenesis, we used a new ex vivo perfusion chamber model to examine blood from patients with different subtypes of Glanzmann's thrombasthenia (GT). Non-anticoagulated blood was perfused through capillaries coated with ...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2141.2002.03966.x

    authors： Hainaud P,Brouland JP,André P,Simoneau G,Bal Dit Sollier C,Drouet L,Caen J,Bellucci S

    更新日期：2002-12-01 00:00:00

  • Myeloma-reactive allospecific cytotoxic T lymphocytes lyse target cells via the granule exocytosis pathway.

    abstract：:Accumulating evidence indicates that a graft-vs.-myeloma effect (GVM) and its associated clinical remission of the disease can be induced by donor lymphocyte infusion in myeloma patients who have relapsed after allogeneic bone marrow transplantation. Although it is believed that GVM is induced by allospecific T cells,...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2141.2001.02531.x

    authors： Chiriva-Internati M,Du J,Cannon M,Barlogie B,Yi Q

    更新日期：2001-02-01 00:00:00

  • Platelet aggregating IgG antibody to platelet surface glycoproteins associated with thrombosis and thrombocytopenia.

    abstract：:Previously described platelet-aggregating antibodies associated with thrombosis and thrombocytopenia required heparin for their in vivo and in vitro expression. We have observed a patient with thrombosis who became thrombocytopenic during heparin treatment, but who suffered further thrombotic events and continued thro...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1990.tb02592.x

    authors： Pfueller SL,David R,Firkin BG,Bilston RA,Cortizo WF,Raines G

    更新日期：1990-03-01 00:00:00

  • Thrombomodulin with the Asp468Tyr mutation is expressed on the cell surface with normal cofactor activity for protein C activation.

    abstract：:Thrombomodulin (TM) is an endothelial cell glycoprotein that acts as an anticoagulant. Mutation in the TM gene is a potential risk factor for thrombosis. The first TM mutation identified was a heterozygous substitution of T for G at nucleotide position 1456, which predicted Asp468 with Tyr in a Ser/Thr-rich domain. To...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2141.1999.01567.x

    authors： Nakazawa F,Koyama T,Saito T,Shibakura M,Yoshinaga H,Chung DH,Kamiyama R,Hirosawa S

    更新日期：1999-08-01 00:00:00

  • Evaluation of the supertransfusion regimen in homozygous beta-thalassaemia children.

    abstract：:The maintenance of physiological levels of haemoglobin is beneficial in the management of patients with thalassaemia major since it leads to better tissue oxygenation, reduction of blood volume, and reduced intestinal absorption of iron. We have studied 11 patients with thalassaemia major while treating them for 4-12 ...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1982.tb03867.x

    authors： Masera G,Terzoli S,Avanzini A,Fontanelli G,Mauri RA,Piacentini G,Ferrari M

    更新日期：1982-09-01 00:00:00

  • Eltrombopag preferentially expands haematopoietic multipotent progenitors in human aplastic anaemia.

    abstract：:Eltrombopag has been added to first-line treatment of immune aplastic anaemia (AA), resulting in higher responses. We analysed marrow samples of AA patients who responded to immunosuppressive therapy (IST) alone or in combination with eltrombopag for the composition of the haematopoietic stem and progenitor cell (HSPC...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/bjh.17140

    authors： Quintino de Oliveira B,Catto LFB,Santana BAA,Tellechea MF,Scheucher PS,Scheinberg P,Calado RT

    更新日期：2020-11-20 00:00:00

  • Platelet von Willebrand factor--structure, function and biological importance.

    abstract：:Besides circulating in normal plasma, von Willebrand factor (VWF) is also stored at relatively high concentration within the alpha-granules of platelets. This pool of platelet VWF exists distinct from plasma VWF, and is enriched in haemostatically-active high molecular weight multimers. Interestingly, the glycosylatio...

    journal_title：British journal of haematology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2141.2009.08052.x

    authors： McGrath RT,McRae E,Smith OP,O'Donnell JS

    更新日期：2010-03-01 00:00:00

  • Plasma levels of platelet factor 4 measured by radioimmunoassay.

    abstract：:A radioimmunoassay has been developed to measure platelet factor 4 (PF4) in biological fluids both in vitro and in vivo. The assay has been shown to be highly specific for PF4 and has a sensitivity of 0.08 ng/assay tube and 1.6 ng/ml of plasma. The preparation of plasma for the measurement of in vivo levels of PF4 req...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1978.tb05819.x

    authors： Chesterman CN,McGready JR,Doyle DJ,Morgan FJ

    更新日期：1978-11-01 00:00:00

  • Interleukin 2 enhances cytotoxic cell function in vitro after T-cell depleted marrow transplantation.

    abstract：:After T-cell depleted marrow transplantation, there is a rapid recovery of cytotoxic effector cells, with activity against targets not susceptible to killing by 'resting' natural killer cells. These targets include Epstein-Barr virus transformed B cells and leukaemic cell lines. Activated killer cell function declines...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1987.tb02347.x

    authors： Leger O,Drexler HG,Reittie JE,Secker-Walker L,Prentice HG,Brenner MK

    更新日期：1987-11-01 00:00:00

  • Novel BCR-ABL transcript containing an intronic sequence insert in a patient with Philadelphia-positive acute lymphoblastic leukaemia.

    abstract：:In a patient with Philadelphia chromosome-positive acute lymphoblastic leukaemia (ALL), a novel variant of the chimaeric BCR-ABL mRNA transcript was detected by reverse transcription polymerase chain reaction (RT-PCR). Sequencing revealed the novel transcript to be a chimaeric mRNA produced by fusion of the BCR exon 1...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2141.2000.02205.x

    authors： Hirota M,Hidaka E,Ueno I,Ishikawa M,Asano N,Yamauchi K,Ishida F,Tozuka M,Katsuyama T

    更新日期：2000-09-01 00:00:00

  • Highly purified CD38 sub-populations show no evidence of preferential clonal evolution despite having increased proliferative activity when compared with CD38 sub-populations derived from the same chronic lymphocytic leukaemia patient.

    abstract：:In agreement with a recently published manuscript, this present study demonstrated that CD38+ sub-populations had increased proliferative activity as evidenced by higher Ki-67 expression (P < 0.0001). This raised the possibility that the CD38+ fraction is exposed to an increased risk of clonal evolution. However, seri...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.2008.07236.x

    authors： Lin TT,Hewamana S,Ward R,Taylor H,Payne T,Pratt G,Baird D,Fegan C,Pepper C

    更新日期：2008-08-01 00:00:00

  • Guidelines for the management of mature T-cell and NK-cell neoplasms (excluding cutaneous T-cell lymphoma).

    abstract：:The peripheral T-cell neoplasms are a biologically and clinically heterogeneous group of rare disorders that result from clonal proliferation of mature post-thymic lymphocytes. Natural killer (NK) cell neoplasms are included in this group. The World Health Organization classification of haemopoietic malignancies has d...

    journal_title：British journal of haematology

    pub_type： 杂志文章,实务指引,评审

    doi：10.1111/j.1365-2141.2011.08651.x

    authors： Dearden CE,Johnson R,Pettengell R,Devereux S,Cwynarski K,Whittaker S,McMillan A,British Committee for Standards in Haematology.

    更新日期：2011-05-01 00:00:00

  • The issue of consent in medical practice.

    abstract：:Following a recent court judgment, legal and moral issues surrounding consent have been thrown into the spotlight. Elizabeth Larner, Solicitor, and Rachel Carter, Partner, of Wollen Michelmore LLP, look at the issues surrounding consent, including where problems arise in the fields of clinical negligence and non-accid...

    journal_title：British journal of haematology

    pub_type： 杂志文章,评审

    doi：10.1111/bjh.13795

    authors： Larner E,Carter R

    更新日期：2016-01-01 00:00:00

  • The incidence of dysfunctional antithrombin variants: four cases in 210 patients with thromboembolic disease.

    abstract：:210 patients, with a history of venous thrombosis, have undergone prothrombotic investigations. In nine cases a consistent deficiency of antithrombin was identified. In five there was a reduction in the plasma antigenic concentration of antithrombin and in a further four cases deficiency was due to the presence of a d...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1991.tb08584.x

    authors： Harper PL,Luddington RJ,Daly M,Bruce D,Williamson D,Edgar PF,Perry DJ,Carrell RW

    更新日期：1991-03-01 00:00:00

  • Improved intensive care unit survival for critically ill allogeneic haematopoietic stem cell transplant recipients following reduced intensity conditioning.

    abstract：:The use of allogeneic haematopoietic stem cell transplantation (Allo-HSCT) is a standard treatment option for many patients with haematological malignancies. Historically, patients requiring intensive care unit (ICU) admission for transplant-related toxicities have fared extremely poorly, with high ICU mortality rates...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/bjh.12294

    authors： Townsend WM,Holroyd A,Pearce R,Mackinnon S,Naik P,Goldstone AH,Linch DC,Peggs KS,Thomson KJ,Singer M,Howell DC,Morris EC

    更新日期：2013-05-01 00:00:00

  • Activation of endothelium by immunotherapy with interleukin-2 in patients with malignant disorders.

    abstract：:Treatment with intravenous recombinant human interleukin-2 (rh IL-2) is frequently accompanied by the capillary leak syndrome and disturbances of the coagulation system. Although the exact mechanisms are still not fully understood, the involvement of the endothelium is proven. This investigation aimed to elucidate mor...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2141.1999.01453.x

    authors： Locker GJ,Kapiotis S,Veitl M,Mader RM,Stoiser B,Kofler J,Sieder AE,Rainer H,Steger GG,Mannhalter C,Wagner OF

    更新日期：1999-06-01 00:00:00

  • Surface immunoglobulin on B lymphocytes as a potential target for specific peptide ligands in chronic lymphocytic leukaemia.

    abstract：:With the aim of producing unique targets for malignant cells we have identified peptide ligands for the clonal surface immunoglobulin isolated from the B cells of a chronic lymphocytic leukaemia (CLL) patient. The peptides were identified from random-peptide phage-display libraries. The obtained ligands bound specific...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.0007-1048.2001.03311.x

    authors： Buhl L,Szecsi PB,Gisselø GG,Schafer-Nielsen C

    更新日期：2002-03-01 00:00:00

  • How we manage haemostasis during sepsis.

    abstract：:Sepsis may be associated with activation of the coagulation system and, in its most severe form, may result in disseminated intravascular coagulation (DIC). Initially, there is thrombosis primarily affecting small and medium sized vessels and contributing to organ dysfunction, but continued activation results in consu...

    journal_title：British journal of haematology

    pub_type： 杂志文章,评审

    doi：10.1111/bjh.15821

    authors： Scully M,Levi M

    更新日期：2019-04-01 00:00:00

  • Inhibition of platelet function with 2,3-dihydroxybenzoic acid.

    abstract：:2,3-Dihydroxybenzoic acid (2,3-DHB) inhibits the second wave of platelet aggregation release of serotonin, and malonaldehyde production. The effect is concentration dependent and reversible in vitro and in vivo. 50% inhibition of platelet aggregation induced in vitro with 70 micron adrenaline was obtained with 1.5 mM ...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1977.tb01030.x

    authors： Greenberg M,Grady RW,Peterson CM

    更新日期：1977-12-01 00:00:00

  • Hb Arta [beta 45 (CD4) Phe-->Cys]: a new unstable haemoglobin with reduced oxygen affinity in trans with beta-thalassaemia.

    abstract：:The interaction of rare Hb variants with beta(0)-thalassaemia results in a quasihomozygous state where the erythrocytes contain the variant as the only major adult Hb component. Such a situation is a unique model that enables functional studies even in the case of a neutral variant that could not be isolated from Hb A...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1995.tb05353.x

    authors： Vassilopoulos G,Papassotiriou I,Voskaridou E,Stamoulakatou A,Premetis E,Kister J,Marden M,Griffon N,Poyart C,Wajcman H

    更新日期：1995-11-01 00:00:00

  • The Duffy blood group determinants: their role in the susceptibility of human and animal erythrocytes to Plasmodium knowlesi malaria.

    abstract：:Duffy blood group negative erythrocytes from blacks are refractory to invasion by Plasmodium knowlesi merozoites in vitro, and blacks with this genotype are resistant to infection by P. vivax in vivo. In order to evaluate in a direct manner the role of Duffy blood group determinants in invasion by P. knowlesi merozoit...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2141.1977.tb00656.x

    authors： Mason SJ,Miller LH,Shiroishi T,Dvorak JA,McGinniss MH

    更新日期：1977-07-01 00:00:00

  • Frequent deletion of chromosome 12p12.3 in children with acute lymphoblastic leukaemia.

    abstract：:Cytogenetic deletions of the short arm of chromosome 12 are common recurring alterations found in a wide range of haematological neoplasias, including childhood acute lymphoblastic leukaemia (ALL), the most frequent paediatric malignancy. Such a loss of genetic material suggests the presence of a tumour suppressor gen...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2141.1997.3663180.x

    authors： Baccichet A,Sinnett D

    更新日期：1997-10-01 00:00:00

  • Induction of the CD163-dependent haemoglobin uptake by macrophages as a novel anti-inflammatory action of glucocorticoids.

    abstract：:Highly efficient systems remove toxic and pro-inflammatory haemoglobin (Hb) from the circulation and local sites of tissue damage. Macrophages are major Hb-clearing cells; CD163 was recently recognized as the specific haemoglobin-haptoglobin scavenger receptor (HSR). We show that dexamethasone strongly induced the spe...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2141.2002.03790.x

    authors： Schaer DJ,Boretti FS,Schoedon G,Schaffner A

    更新日期：2002-10-01 00:00:00

  • Quality of life during and following sequential treatment of previously untreated patients with multiple myeloma: findings of the Medical Research Council Myeloma IX randomised study.

    abstract：:In the Medical Research Council (MRC) Myeloma IX trial (ISRCTN684564111) patients were randomised to sodium clodronate or zoledronic acid and induction treatment: cyclophosphamide, vincristine, doxorubicin and dexamethasone (CVAD) or cyclophosphamide, thalidomide and dexamethasone (CTD) followed by autologous stem cel...

    journal_title：British journal of haematology

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/bjh.15459

    authors： Royle KL,Gregory WM,Cairns DA,Bell SE,Cook G,Owen RG,Drayson MT,Davies FE,Jackson GH,Morgan GJ,Child JA

    更新日期：2018-09-01 00:00:00

  • FLT3 internal tandem duplication mutations in adult acute myeloid leukaemia define a high-risk group.

    abstract：:Genomic DNA from 106 cases of adult de novo acute myeloid leukaemia (AML) was screened by polymerase chain reaction (PCR) and gel electrophoresis for FLT3 internal tandem duplication (ITD) mutations within the juxtamembrane (JM) domain. FLT3 mutations were detected in 14 cases (13.2%) and occurred in FAB types M1 (4 o...

    journal_title：British journal of haematology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2141.2000.02317.x

    authors： Abu-Duhier FM,Goodeve AC,Wilson GA,Gari MA,Peake IR,Rees DC,Vandenberghe EA,Winship PR,Reilly JT

    更新日期：2000-10-01 00:00:00