Nerve growth factor stimulation of mouse embryonal carcinoma cell migration.

abstract：:Renal cell carcinoma is frequently infiltrated by cells of the immune system. This makes it important to understand interactions between cancer cells and immune cells so they can be manipulated to bring clinical benefit. Here, we analyze subsets and functions of T lymphocytes infiltrating renal cell tumors directly ex...

journal_title：Cancer research

authors： Attig S,Hennenlotter J,Pawelec G,Klein G,Koch SD,Pircher H,Feyerabend S,Wernet D,Stenzl A,Rammensee HG,Gouttefangeas C

更新日期：2009-11-01 00:00:00

abstract：:The immunoreceptor NKG2D originally identified in natural killer (NK) cells recognizes ligands that are upregulated on tumor cells. Expression of NKG2D ligands (NKG2DL) is induced by the DNA damage response (DDR), which is often activated constitutively in cancer cells, revealing them to NK cells as a mechanism of imm...

journal_title：Cancer research

authors： Lam AR,Bert NL,Ho SS,Shen YJ,Tang LF,Xiong GM,Croxford JL,Koo CX,Ishii KJ,Akira S,Raulet DH,Gasser S

更新日期：2014-04-15 00:00:00

abstract：:Patients with longstanding extensive ulcerative colitis have an increased risk of developing colorectal cancer (CRC). There are significant differences in the early pathogenesis of colitis-associated tumors compared with common CRC, whereas the frequency, degree, and significance of microsatellite instability (MSI) as...

journal_title：Cancer research

authors： Kohonen-Corish MR,Daniel JJ,te Riele H,Buffinton GD,Dahlstrom JE

更新日期：2002-04-01 00:00:00

abstract：:A major challenge in treating cancer is the difficulty of bringing therapy to poorly perfused areas of solid tumors, which are often most resistant to chemotherapy and radiation. GRP94 is a chaperone protein localized in the endoplasmic reticulum with antiapoptotic properties. We report here that in vitro the proximal...

journal_title：Cancer research

authors： Reddy RK,Dubeau L,Kleiner H,Parr T,Nichols P,Ko B,Dong D,Ko H,Mao C,DiGiovanni J,Lee AS

更新日期：2002-12-15 00:00:00

abstract：:It is known that Wnt-1 signaling inhibits apoptosis by activating beta-catenin/tcf-mediated transcription. Here, we show that blocking Wnt-1 signaling in beta-catenin-deficient mesothelioma cell lines H28 and MS-1 induces apoptotic cell death. Both Wnt-1 small interfering RNA (siRNA) and Dishevelled siRNA induced sign...

journal_title：Cancer research

authors： You L,He B,Uematsu K,Xu Z,Mazieres J,Lee A,McCormick F,Jablons DM

更新日期：2004-05-15 00:00:00

abstract：:The chemokine receptor, CXCR4, is expressed by human melanomas, and its ligand, CXCL12, is frequently produced at sites of melanoma metastasis. Herein, we examine CXCR4-enhanced binding of B16 murine melanoma cells to endothelial cells (ECs) and recombinant adhesion molecules in vitro to determine the role of tumor- a...

journal_title：Cancer research

authors： Cardones AR,Murakami T,Hwang ST

更新日期：2003-10-15 00:00:00

abstract：:Nucleoside kinases from several species are investigated as suicide genes for treatment of malignant tumors by combined gene/chemotherapy. In the present study, we have investigated a novel strategy where nucleoside kinase proteins are directly delivered to cells without delivery of genetic material. We used a mix of ...

journal_title：Cancer research

authors： Zheng X,Lundberg M,Karlsson A,Johansson M

更新日期：2003-10-15 00:00:00

abstract：:The transplantable hormone-responsive rat mammary adenocarcinoma 13762NF was dissociated with collagenase and hyaluronidase. Cells were cloned directly or lines were established from mass cultures and cells from these lines were cloned. Clones differed in cellular morphology, colony morphology on plastic or in collage...

journal_title：Cancer research

authors： Geradts J,Richards J,Edery M,Pang K,Larson L,Nandi S

更新日期：1986-04-01 00:00:00

abstract：:Anti-VEGF pathway therapies primarily target immature blood vessels in tumors. However, emerging approaches to combine with targeted therapies impacting the later stages of remodeling and vessel maturation are expected to improve clinical efficacy by expanding the target vessel population. The angiopoietin/Tie ligand/...

journal_title：Cancer research

authors： Gerald D,Chintharlapalli S,Augustin HG,Benjamin LE

更新日期：2013-03-15 00:00:00

abstract：:A bovine serum albumin-conjugated doxorubicin via the glutaraldehyde bridge (BSA-DXR conjugate) showed potent dose-dependent inhibition of cell growth against daunorubicin-resistant AH66 (AH66DR) cells as well as parental AH66 (AH66P) cells in vitro as compared to treatment with DXR or BSA-glutaraldehyde conjugate wit...

journal_title：Cancer research

authors： Ohkawa K,Hatano T,Yamada K,Joh K,Takada K,Tsukada Y,Matsuda M

更新日期：1993-09-15 00:00:00

abstract：:The metastasizing MDAY-D2 tumor of DBA/2 mice disseminates in BALB/c allogeneic athymic nude (nu/nu) mice in a manner identical to that observed in the syngeneic host. Both the kinetics and organ distribution pattern of metastases from s.c. implants of MDAY-D2 are routinely predictable at any given tumor dose. BALB/c ...

journal_title：Cancer research

authors： Wiltrout RH,Frost P,Morrison MK,Kerbel RS

更新日期：1979-10-01 00:00:00

abstract：:Organization of cancer cells into endothelial-like cell-lined structures to support neovascularization and to fuel solid tumors is a hallmark of progression and poor outcome. In triple-negative breast cancer (TNBC), PDGFRβ has been identified as a key player of this process and is considered a promising target for bre...

journal_title：Cancer research

authors： D'Ippolito E,Plantamura I,Bongiovanni L,Casalini P,Baroni S,Piovan C,Orlandi R,Gualeni AV,Gloghini A,Rossini A,Cresta S,Tessari A,De Braud F,Di Leva G,Tripodo C,Iorio MV

更新日期：2016-09-15 00:00:00

abstract：:L-Histidinol, an analogue of the amino acid L-histidine, has been reported to be able to increase the specificity of 5-fluorouracil (FUra), through both protection of normal tissues at risk and potentiation of leukemic cell killing. It is postulated that this occurs through prevention of the entry of normal cells into...

journal_title：Cancer research

authors： Edelstein MB,Heilbrun LK

更新日期：1988-03-15 00:00:00

abstract：:Immune checkpoint therapies exhibit impressive efficacy in some patients with melanoma or lung cancer, but the lack of response in most cases presses the question of how general efficacy can be improved. In addressing this question, we generated a preclinical tumor model to study anti-PD-1 resistance by in vivo passag...

journal_title：Cancer research

authors： Wang X,Schoenhals JE,Li A,Valdecanas DR,Ye H,Zang F,Tang C,Tang M,Liu CG,Liu X,Krishnan S,Allison JP,Sharma P,Hwu P,Komaki R,Overwijk WW,Gomez DR,Chang JY,Hahn SM,Cortez MA,Welsh JW

更新日期：2017-02-15 00:00:00

abstract：:Ribonucleotide reductase (RR) is responsible for the de novo conversion of the ribonucleoside diphosphates to deoxyribonucleoside diphosphates, which are essential for DNA synthesis and repair. RR consists of two subunits, hRRM1 and hRRM2. p53R2 is a new RR family member. Because the majority of human tumors possess m...

journal_title：Cancer research

authors： Zhou B,Liu X,Mo X,Xue L,Darwish D,Qiu W,Shih J,Hwu EB,Luh F,Yen Y

更新日期：2003-10-15 00:00:00

abstract：:Cells lacking the tumor suppressor gene LKB1/STK11 alter their metabolism to match the demands of accelerated growth, leaving them highly vulnerable to stress. However, targeted therapy for LKB1-deficient cancers has yet to be reported. In both Kras/p53/Lkb1 cell lines and a genetically engineered mouse model of Kras/...

journal_title：Cancer research

authors： Liu Y,Li Y,Wang X,Liu F,Gao P,Quinn MM,Li F,Merlino AA,Benes C,Liu Q,Gray NS,Wong KK

更新日期：2017-09-15 00:00:00

abstract：:ERBB4/HER4 (referred to here as ERBB4) is a unique member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. In contrast to the other three members of the EGFR family (i.e., EGFR, ERBB2/HER2/NEU, and ERBB3), which are associated with aggressive forms of human cancers, ERBB4 expression ...

journal_title：Cancer research

authors： Naresh A,Long W,Vidal GA,Wimley WC,Marrero L,Sartor CI,Tovey S,Cooke TG,Bartlett JM,Jones FE

更新日期：2006-06-15 00:00:00

abstract：:Cisplatin (cis-diamminedichloroplatinum, CDDP) is one of the most used drugs for osteosarcoma chemotherapy. By using a series of CDDP-resistant variants, which were established from the U-2OS and Saos-2 human osteosarcoma cell lines, we found that CDDP resistance was mainly associated with the increase of both the int...

journal_title：Cancer research

authors： Pasello M,Michelacci F,Scionti I,Hattinger CM,Zuntini M,Caccuri AM,Scotlandi K,Picci P,Serra M

更新日期：2008-08-15 00:00:00

abstract：:The pharmacology of high-dose 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT) has been studied by radiochemical and chromatographic techniques in eight patients. Plasma disappearance of FT was exponential, with a half-life of 8.8 hr. Plasma concentrations of 5-fluorouracil (FUra) were sustained at 12.8 nmol/ml (1.7 micro...

journal_title：Cancer research

authors： Benvenuto JA,Lu K,Hall SW,Benjamin RS,Loo TL

更新日期：1978-11-01 00:00:00

abstract：:The cytochrome P-450 in hepatic microsomes prepared from rats pretreated with hematoporphyrin derivative was shown to be rapidly destroyed in the presence of long-wave ultraviolet light. The photocatalytic destruction of the heme-protein was dependent on both the dose of ultraviolet light and of hematoporphyrin deriva...

journal_title：Cancer research

authors： Das M,Dixit R,Mukhtar H,Bickers DR

更新日期：1985-02-01 00:00:00

abstract：:DNA content and in situ sensitivity to denaturation were analyzed by flow cytometry of individual cell nuclei isolated from 40 breast carcinomas, nine fibroadenomas, and 14 samples of normal breast tissue. The extent of DNA denaturation induced by acid was expressed as alpha t, which represents the fraction of DNA sta...

journal_title：Cancer research

authors： Kunicka JE,Olszewski W,Rosen PP,Kimmel M,Melamed MR,Darzynkiewicz Z

更新日期：1989-11-15 00:00:00

abstract：:Plasma membrane preparations from Chinese hamster lung cells, which are resistant to the antitumor agent Adriamycin, were analyzed using fluorescence polarization of the membrane lipid probe trans-parinaric acid. The results of these studies reveal that membranes from several drug-resistant isolates have a substantial...

journal_title：Cancer research

authors： Rintoul DA,Center MS

更新日期：1984-11-01 00:00:00

abstract：:Colony-forming capacity of human melanoma cells was investigated in five established cell lines and isolated cells from seven metastatic or recurrent tumors. A single-cell suspension was added to 0.3% agar medium, and colonies were observed over 7 to 21 days. With the five cell lines, colony formation occurred in all ...

journal_title：Cancer research

authors： Asano S,Riglar C

更新日期：1981-03-01 00:00:00

abstract：:The tumor microenvironment is characterized by regions of fluctuating and chronic hypoxia, low pH, and nutrient deprivation. It has been proposed that this unique tissue environment itself may constitute a major cause of the genetic instability seen in cancer. To investigate possible mechanisms by which the tumor micr...

journal_title：Cancer research

authors： Yuan J,Narayanan L,Rockwell S,Glazer PM

更新日期：2000-08-15 00:00:00

abstract：:Phosphorylation of heat shock protein 27 (HSP27) has been suggested to play an important role in the regulation of F-actin dynamics in response to growth factors and stress. Because the microfilament network is one of the earliest targets of oxidative stress and because phosphorylation of HSP27 is strongly induced by ...

journal_title：Cancer research

authors： Huot J,Houle F,Spitz DR,Landry J

更新日期：1996-01-15 00:00:00

abstract：:Immunologic targeting of the oncoprotein HER2/neu with monoclonal antibodies is an important component of current therapeutic strategies for patients with locally and systemically advanced breast cancer. Engineered antibodies targeting HER2 may have agonist or antagonist effects on HER2, but little is known about whet...

journal_title：Cancer research

authors： Montgomery RB,Makary E,Schiffman K,Goodell V,Disis ML

更新日期：2005-01-15 00:00:00

abstract：:The potential role of alpha5beta1 integrins in cancer has recently attracted much interest. However, few alpha5beta1-selective antagonists have been developed compared with other integrins. The most specific nonpeptidic alpha5beta1 antagonist described thus far, SJ749, inhibits angiogenesis by affecting adhesion and m...

journal_title：Cancer research

authors： Maglott A,Bartik P,Cosgun S,Klotz P,Rondé P,Fuhrmann G,Takeda K,Martin S,Dontenwill M

更新日期：2006-06-15 00:00:00

abstract：:The antitumor activity of IFN-alpha is well established. However, the role of the plasmacytoid dendritic cell (PDC), the major producer of IFN-alpha upon viral infection, in tumor biology is unknown. We sought to study the presence and function of PDC in a human solid tumor. Here, we demonstrate that PDCs infiltrate t...

journal_title：Cancer research

authors： Hartmann E,Wollenberg B,Rothenfusser S,Wagner M,Wellisch D,Mack B,Giese T,Gires O,Endres S,Hartmann G

更新日期：2003-10-01 00:00:00

abstract：:Diagnosis of hepatitis B virus (HBV)-positive hepatocellular carcinoma (HCC), particularly HCC independent of cirrhosis etiology, presents a great challenge because of a lack of biomarkers. Here we test the hypothesis that expression profiles of microRNAs (miRNAs) in serum can serve as biomarkers for diagnosis of HBV ...

journal_title：Cancer research

authors： Li LM,Hu ZB,Zhou ZX,Chen X,Liu FY,Zhang JF,Shen HB,Zhang CY,Zen K

更新日期：2010-12-01 00:00:00

abstract：:The accumulated literature suggests that altering the immune capacities of animals or humans seldom has detectable effects on tumor incidence nor, it seems, does the growth of an untransplanted tumor, either spontaneous or induced, immunize the host against the growth of a subsequent implant of that tumor. These obser...

journal_title：Cancer research

authors： Prehn RT

更新日期：1994-02-15 00:00:00