Cis(Z)-clopenthixol and clopenthixol (Sordinol) in chronic psychotic patients. A double-blind clinical investigation.

Abstract:

:The clinical effect of cis(Z)-clopenthixol has been compared with that of clopenthixol, which is a mixture of the pharmacologically active cis(Z)-isomer and the inactive trans(E)-isomer. In the 2-month double-blind trial were included 57 psychotic patients, mainly schizophrenics. Ratings evaluating severity of illness, therapeutic effect, possible interference of side effects with the patient's functioning, as well as any individual side effects were done at months 0, 1, and 2. The antipsychotic effect of cis(Z)-clopenthixol was found equal to that of clopenthixol whereas the cis(Z)-isomer on a mg/mg basis was twice as active as clopenthixol. Apart from the finding that the unspecific sedative effect appeared to be less marked with cis(Z)-clopenthixol, the type, degree, and frequency of side effects were the same in the two groups of patients. More than half of the patients experienced no side effects.

journal_name

Acta Psychiatr Scand

authors

Gravem A,Engstrand E,Guleng RJ

doi

10.1111/j.1600-0447.1978.tb03570.x

subject

Has Abstract

pub_date

1978-11-01 00:00:00

pages

384-8

issue

5

eissn

0001-690X

issn

1600-0447

journal_volume

58

pub_type

临床试验,杂志文章
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