Abstract:
:Chronic pancreatitis is a persistent inflammatory disorder of the pancreas, characterized by destruction of the pancreatic parenchyma, maldigestion, chronic pain and diabetes mellitus. Genetic factors determining susceptibility to chronic pancreatitis can be classified in two groups: 1. rare gene mutations affecting the cationic trypsinogen gene that directly cause the disease, and 2. genetic variants that increase the risk for chronic pancreatitis but require additional risk factors to precipitate the disease. These gene variants are considered genetic risk factors, which emerged during the past decade and now represent a clinically important etiological category. Susceptibility to chronic pancreatitis is inherited in a complex manner, which can involve alterations in several genes conferring various degrees of risk. The biochemical mechanism behind the genetic risk includes increased ectopic activation of the digestive enzyme trypsin in the pancreas and failure of protective mechanisms responsible for trypsin inactivation.
journal_name
Orv Hetiljournal_title
Orvosi hetilapauthors
Sahin-Tóth M,Hegyi P,Tóth Mdoi
10.1556/OH.2008.28441subject
Has Abstractpub_date
2008-09-07 00:00:00pages
1683-8issue
36eissn
0030-6002issn
1788-6120pii
8706180J4NV74632journal_volume
149pub_type
杂志文章,评审相关文献
ORVOSI HETILAP文献大全abstract::Authors analysed 25 colorectal cancer lung metastases. Among them were 13 male 12 female. Ages ranged from 45 to 70 years. The lung nodules were discovered without any symptoms in 19 cases. The disease was localized on the right in 16 patients, in 7 on the left side and 2 others were bilateral. There were 19 solitary ...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1995-01-29 00:00:00
abstract:INTRODUCTION:Extension of electrocardiographic monitoring via loop recorder implantation may increase the diagnostic yield of syncope work-up. AIM:In this retrospective observational study, the authors wanted to evaluate the diagnostic performance of implantable loop recorder in the everyday clinical practice. METHOD...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2015.30124
更新日期:2015-04-01 00:00:00
abstract::This is a review of several mechanisms in the acute and chronic progress of viral hepatitis. Investigation of these mechanisms may have an important role in the diagnosis and treatment of chronic hepatitis. Clinical features of acute non-A, non-B hepatitis were studied in 110 patients. Most of the patients had a surgi...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1992-07-05 00:00:00
abstract::The authors detected Epstein-Barr virus (EBV) virus capsid (VCA) antibodies of IgM and IgG type together with EBNA and heterophil antibodies in the sera collected from 1882 unselected patients without infectious mononucleosis. Out of them IgM type antibodies were found in 123 cases and in an additional group of 30 pat...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1996-07-28 00:00:00
abstract::In our recent work we present two cases of coexisting Sjögren's syndrome and myeloma multiplex. Our results obtained studying a high number of patients suggest that the occurrence of myeloma in Sjögren's syndrome is much higher than in normal population. This can possibly be explained by the common pathogenetical fact...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2000-09-17 00:00:00
abstract:UNLABELLED:The need of outcome measures from the patients' aspect emerges reasonably in the field of rapidly developing pediatric cardiac surgery and pediatric cardiology. The professional standards and the possibilities of applicability of quality of life measures are often unknown for medical doctors. This is particu...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2008.28278
更新日期:2008-09-14 00:00:00
abstract::Transcatheter arterial oily chemoembolization using cytostatics mixed with lymphographic contrast agent with or without Gelfoam embolization seems currently to be the most suitable treatment for unresectable hepatocellular carcinomas (HCC). 5 patients with inoperable, biopsy proven huge HCC (average size 404 cm2) were...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1994-01-30 00:00:00
abstract::Incidence of gastrointestinal tuberculosis increases in the western world. Exact epidemiological data about this rare extrapulmonological disease are not available in Hungary. Three advanced cases with intestinal tuberculosis have been reported, all of them recognised during surgery due to complications. The clinicopa...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1998-02-01 00:00:00
abstract::The hepatitis C virus is an RNA virus, which belongs to the genus Hepaciviruses of the family Flaviviridae. Chronic hepatitis, cirrhosis, and ultimately even liver cancer may develop in over 80% of infected cases. The histological features of hepatitis C and hepatitis caused by other hepatotropic viruses show many sim...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/650.2015.30178
更新日期:2015-05-24 00:00:00
abstract::Inclusion body myositis is an acquired inflammatory muscle disease belonging to the family of idiopathic inflammatory myopathy with vacuole formation. Approximately 15-28% of idiopathic inflammatory myopathy patients suffer from inclusion body myositis. Early diagnosis is very important due to the slowly progressive d...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/OH.2008.28070
更新日期:2008-07-27 00:00:00
abstract:INTRODUCTION:Many new prognostic factors established in recent years in chronic lymphocytic leukemia. May help predicting survival. AIMS:The goal of the present study was to determine the frequency and the correlation of these novel prognostic factors in samples of 419 leukemia patients. METHODS:The mutation status o...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2007.27943
更新日期:2007-04-22 00:00:00
abstract::The detection of vasospasm plays an important role for the definition of the strategy of treatment in patients with subarachnoid hemorrhage (SAH). Besides the invasive contrast angiography, the non-invasive 99m-Tc-HMPAO brain perfusion SPECT and transcranial Doppler sonography (TCD) are recently used for this purpose....
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1996-08-18 00:00:00
abstract::What is PICC line insertion? The PICC is a soft, flexible catheter which is made of polyurethane or silicone, and is inserted via an upper or lower extremity peripheral vein into superior or inferior vena cava. The origin of PICC line dates back to the early 1950s. Since the introduction of the PICC catheter, this met...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/650.2017.30765
更新日期:2017-06-01 00:00:00
abstract::The paper gives an introduction to the basis and quality control of a relatively new imaging method. First the different kinds of SPECT instruments, and then the aspects of diagnostic application are described. Details are given on examinations of the central nervous system, the abdomen, the hearth and the skeletal sy...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:1989-03-19 00:00:00
abstract:UNLABELLED:The specific diagnosis of herpes simplex virus type 1 and 2 infections has an extreme importance in acute infections of central nervous system due to both availability of specific antiviral therapy and the possible serious consequences of the disease. AIMS:Evaluation of the relevance and interpretation of t...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2010.28921
更新日期:2010-11-14 00:00:00
abstract::L. J. Thénard and J. L. Gay-Lussac discovered hydrogen peroxide in 1818. Later, Thénard noticed that animal and plant tissues decompose hydrogen peroxide. The substance which is responsible for this reaction was named as catalase by O. Loew in 1900. The catalase enzyme was regarded as a diagnostic and a tumour marker ...
journal_title:Orvosi hetilap
pub_type: 历史文章,杂志文章
doi:10.1556/650.2018.31096
更新日期:2018-06-01 00:00:00
abstract:INTRODUCTION:Healthcare associated infections and antimicrobial use are common among residents of long-term care facilities. Faced to the lack of standardized data, the European Centre for Disease Prevention and Control funded a project with the aim of estimating prevalence of infections and antibiotic use in European ...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2014.29876
更新日期:2014-06-08 00:00:00
abstract::The serum concentrations of squamous cell carcinoma antigen (SCC) were determined in 59 patients with invasive carcinoma of the uterine cervix, in 21 patients with benign cervical diseases. Pretherapeutic SCC levels were elevated (> 2.5 ng/ml) in 63% (34/54) of the patients with squamous cervical carcinoma. 5 patients...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1992-12-13 00:00:00
abstract:INTRODUCTION:It is known that the quality of life (QoL) of patients surgically treated for head and neck cancer (HNC) is significantly enhanced by rehabilitation. It is also known that some of these patients will not quit smoking. AIM:To assess if smoking hampers rehabilitation-related QoL enhancement after surgery. ...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2017.30639
更新日期:2017-02-01 00:00:00
abstract::A case of a young man with eosinophilic gastroenteritis with mucosal involvement in the antrum and duodenum is presented. The diagnosis was based on endoscopic biopsy with histological examination, peripheral blood eosinophilia and gastrointestinal symptoms, like abdominal cramping, nausea, vomiting and diarrhoea. Par...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1994-03-27 00:00:00
abstract::The combination of pegilált interferon plus ribavirin is significantly more effective than conventional interferon plus ribavirin, and is thus the current therapy of choice for patients with chronic hepatitis C. Forty-eight weeks of treatment with combination of pegilált interferon plus ribavirin has produced overall ...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:2006-04-09 00:00:00
abstract:INTRODUCTION:Besides clinicopathological parameters, molecular markers can be very important, and further characterize colorectal carcinomas into chromosomally unstable, microsatellite instable and "CqG-island methylator phenotype" groups. AIM:To study the frequency of microsatellite instability using immunohistochemi...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2015.30218
更新日期:2015-09-06 00:00:00
abstract::The authors describe the clinical course of successfully treated patients with extensive, subtotal pulmonary embolism. After the diagnosis was confirmed by isotopic scan or pulmonary angiography, mechanical thrombus destruction was applied followed by low dose loco-regional thrombolysis in 11 patients by streptokinase...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:1995-11-19 00:00:00
abstract::Regardless of their origin, neuroactive steroids are capable of modifying neural activities by modulating different types of membrane receptors. Neurosteroids are synthesized de novo in neurones and glia. Steroidogenic enzymes are found in the central nervous system. Classical steroid receptors are localized in the cy...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/OH.2007.28139
更新日期:2007-10-14 00:00:00
abstract:UNLABELLED:Due to successful surgical treatment of congenital heart defects in infants and children, the number of patients who reach the adolescent/adult age is continuously increasing. AIMS:The authors sought to identify the short- and medium-term outcomes of reconstruction of right ventricular outflow tract in adol...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/OH.2012.29428
更新日期:2012-08-05 00:00:00
abstract::Diabetes diagnosed in the so-called middle age of life is debated from the typological point of view. The authors investigated 45 diabetics, whose disease had been diagnosed between the age of 30-45 years. As a result of their observations they state that diabetes in this age range is heterogenous. Patients can be cla...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:1990-01-07 00:00:00
abstract::The authors present a case report of a 13.5 yrs old girl. The first manifestation of her diabetes was the sudden decrease of her vision due to bilateral cataract. There was no report of perinatal of actual infection, previous trauma, radiation exposure or drug consumption. She was hypermetropic, for that she regularly...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1999-08-29 00:00:00
abstract::The cutaneous angiotropic lymphoma has a poor prognosis. The diagnosis and the treatment are usually late. The mortality rate is over 80% and the majority of patients die within a year because of the tumorous infiltration of parenchymal organs. The authors report here the medical history and follow up of a still livin...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2005-05-01 00:00:00
abstract::The role of Platelet-Derived Growth Factor (PDGF) was investigated in treatment of experimental inflammatory bowel disease (IBD) in animal models. A new model of IBD induced by the sulfhydryl (SH) alkylator iodoacetamide revealed that the most appropriate concentration of iodoacetamide is 6% given intracolonically onc...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1995-05-14 00:00:00
abstract:INTRODUCTION:Development of atherosclerosis is accelerated in kidney transplant patients. Impaired metabolic pathways have complex effect on the arterial wall which can be measured by non-invasive techniques. Only few data are available on the change of stiffness parameters in the postoperative course. Therefore, in th...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2016-06-12 00:00:00