[Occurrence, intratumoral heterogeneity, prognostic and predictive potential of microsatellite instability following surgical resection of primary colorectal carcinomas and corresponding liver metastases].

Abstract:

INTRODUCTION:Besides clinicopathological parameters, molecular markers can be very important, and further characterize colorectal carcinomas into chromosomally unstable, microsatellite instable and "CqG-island methylator phenotype" groups. AIM:To study the frequency of microsatellite instability using immunohistochemical evaluation of MLH1, MSH2, MSH6 and PMS2 proteins in colorectal carcinoma. METHOD:122 colorectal carcinomas as well as in 69 paired liver metastases were evaluated. Additionally, prognostic and predictive potential of mismatch repair status was tested. RESULTS:Microsatellite instable phenotype was identified in 11.5% (14/122) of the tumours. There were no differences regarding staining intensity of tumour regions. Mismatch repair status was discordant in primaries vs. metastases in 20.2%. There was no difference in progression free- and overall survival according to mismatch repair status. The mismatch repair status was not predictive for survival within systemic therapy regimen groups. CONCLUSIONS:The subgroups of colorectal carcinomas could be evaluated in a larger and homogenised patient cohort to predict prognosis and response to therapy.

journal_name

Orv Hetil

journal_title

Orvosi hetilap

authors

Ágoston EI,Baranyai Z,Dede K,Bodoky G,Kulka J,Bursics A,Harsányi L,Szász AM

doi

10.1556/650.2015.30218

subject

Has Abstract

pub_date

2015-09-06 00:00:00

pages

1460-71

issue

36

eissn

0030-6002

issn

1788-6120

journal_volume

156

pub_type

杂志文章
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    doi:

    authors: Császár T,Patakfalvi A

    更新日期:1993-07-18 00:00:00

  • [Mainz pouch II, a modified method of ureterosigmoidostomy].

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    doi:

    authors: Pajor L,Romics I,Kelemen Z,Frang D

    更新日期:1996-03-31 00:00:00

  • [Malignant fibrous hystiocytomas of unusual localizations].

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    pub_type: 杂志文章

    doi:

    authors: Balázs M,Baksa J,Faller J

    更新日期:1992-11-08 00:00:00

  • [Endoscopic removal of urinary calculi in children].

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    doi:

    authors: Holman E,Tóth C

    更新日期:1989-08-27 00:00:00

  • [Medical therapy of inflammatory bowel diseases: Crohn's disease].

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  • [Colorectal cancer heterogeneity: the clinical impact of sporadic lesions arising via the serrated pathway].

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    doi:10.1556/650.2018.30974

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  • [The effects of drug-eluting coronary stents].

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    pub_type: 杂志文章,评审

    doi:10.1556/OH.2007.28022

    authors: Keltai M

    更新日期:2007-03-11 00:00:00

  • [SPECT--single photon emission computer tomography. A new imaging method in isotope diagnosis].

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    doi:

    authors: Csernay L

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  • [Selenium: its antioxidant effects and issues in selenium supply].

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    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:10.1556/OH.2013.29705

    authors: Molnár J

    更新日期:2013-10-13 00:00:00

  • [Inclusion body myositis pathomechanism and therapy].

    abstract::Inclusion body myositis is an acquired inflammatory muscle disease belonging to the family of idiopathic inflammatory myopathy with vacuole formation. Approximately 15-28% of idiopathic inflammatory myopathy patients suffer from inclusion body myositis. Early diagnosis is very important due to the slowly progressive d...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:10.1556/OH.2008.28070

    authors: Váncsa A,Dankó K

    更新日期:2008-07-27 00:00:00

  • [Malignant cystosarcoma phyllodes: clinico-pathological conference in connection with two cases].

    abstract::Clinical and morphological characteristics of two malignant cystosarcoma phyllodes mammae were reported with the review of recent literature. One of the patients went to see her doctor 2 years after she had noticed the tumour because of "problems in her family". In the removed giant fibroadenoma osteo-chondrosarcomato...

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    pub_type: 杂志文章

    doi:

    authors: Baláz M,Svastics E

    更新日期:1994-10-09 00:00:00

  • [Do we use digitalis properly in the management of elderly patients suffering from the signs of chronic heart failure?].

    abstract:INTRODUCTION:The indications of digoxin therapy has been significantly narrowed and also the effective target therapeutic blood level has been decreased (0.9 micromol/L) compared to the previously desired one. OBJECTIVE:In this retrospective trial the data of 60 consecutive patients over 65 years (25 male, 35 female, ...

    journal_title:Orvosi hetilap

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    doi:

    authors: Erdei F,Vendrey R,Dani G,Kovács E,Márk L,Katona A

    更新日期:2006-10-15 00:00:00

  • [Bilateral renal artery stenosis diagnosed during pregnancy].

    abstract::Bilateral renal artery stenosis was diagnosed noninvasively in the 17th gestational week, in a chronically hypertensive pregnant woman, by renal artery duplex ultrasound examination, MRI and MR angiography. Continuous monitoring of the mother and the fetus was performed. Blood pressure was stabilized by complex antihy...

    journal_title:Orvosi hetilap

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    doi:

    authors: Rigó J,Burger M,Repa I,Vereckei A,Varga I,Pusztai P,Dzsinich C

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  • [Novel treatment modalities in cutaneous T cell lymphoma. Biologic response modifiers].

    abstract::Biologic response modifiers. Biologic response modifiers such as IFN-alpha, retinoids and extracorporeal photopheresis have been widely used in the treatment of cutaneous lymphoma. The novel treatment modalities like cytokine therapies, monoclonal antibodies and fusion proteins have been used only in limited number of...

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    doi:

    authors: Marschalkó M

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  • [Skin as an immune system].

    abstract::Skin consists of three structurally and functionally distinct compartments containing resident and nonresident cells. These cells cooperative with humoral pathway of immune system in defence of healthy skin. Resident and nonresident cells are able to initiate inflammatory or immune processes of skin, although intersti...

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    doi:

    authors: Hunyadi J,Szabó I,Simon M Jr

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  • [Oily contrast medium used for chemoembolization in the palliative treatment of extensive inoperable primary hepatocellular carcinomas].

    abstract::Transcatheter arterial oily chemoembolization using cytostatics mixed with lymphographic contrast agent with or without Gelfoam embolization seems currently to be the most suitable treatment for unresectable hepatocellular carcinomas (HCC). 5 patients with inoperable, biopsy proven huge HCC (average size 404 cm2) were...

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    doi:

    authors: Kónya A,Vigváry Z

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  • [The place of pelvic adhesions in gynecology. Possibilities of prevention].

    abstract::The authors review the recent international literature dealing with the role of pelvic adhesions in gynaecologic surgery. They point out that pelvic adhesions can be detected via laparatomy or laparoscopy in every third patient suffering from chronic pelvic pain, whereas abdominal adhesions revealed rarely correlate w...

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    doi:

    authors: Inovay J,Szendei G

    更新日期:1997-10-05 00:00:00

  • [How did cholesterol levels change in a village in Békés County, Hungary, during the last 20 years?].

    abstract:INTRODUCTION:There are only limited data about the change of cholesterol levels at population level in Hungary. AIM:The aim of the authors was to compare current serum cholesterol levels to those measured 20 years ago in residents of a village in Békés County, Hungary. METHOD:Using a database of a general ptactitione...

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    doi:10.1556/650.2015.30263

    authors: Márk L,Hanyecz V

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  • [Bacterial biofilms and medical practice].

    abstract::A suboptimal environment with limited supply of nutrients leads to marked changes in the microbial features. Similar conditions exist also on some tissue surfaces of the human body and on biomedical devices implanted. The basic feature of this environmental adaptation is the adherence of microbes to some surfaces and ...

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    authors: Kétyi I

    更新日期:1989-11-12 00:00:00

  • [Cognitive functions in type 1 and type 2 diabetes. Meta-analysis].

    abstract:INTRODUCTION:Diabetes has been repeatedly associated with a wide variety of cognitive impairments. AIM:To clarify the differences in cognitive dysfunctions between the two types of diabetes. METHOD:Metaanalysis was performed using databases of Medline, PubMed and ScienceDirect (3 studies with type 1 and 6 with type 2...

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  • [High lactose content of the Lundh test meal adversely affects the reliability of the ALTAB test].

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    authors: Mikó P,Schreiner M,Fehér J

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  • [Laboratory evaluation of immunological dysfunctions in primary immunodeficiency diseases].

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    doi:10.1556/650.2018.31261

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  • [The role of vinpocetine in the treatment of cerebrovascular diseases based in human studies].

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    doi:10.1556/OH.2007.28115

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  • [Experience with transrectal ultrasonic studies in patients with prostatic tumors].

    abstract::The authors present the most typical forms of the prostatic cancer imaged by transrectal ultrasound. They compared the results of investigations of two tumor markers [prostatic specific antigen (PSA), prostatic acid phosphatase (PAP),] the transrectal ultrasound and the rectal palpation. The sensibility of PSA, the ul...

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    authors: Romics I,Rüssel C,Bach D

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  • [Effect of vitamin E supplementation on the vitamin content of lipoprotein in young men and women].

    abstract:UNLABELLED:The effect of supplementary Vitamin E on the vitamin content of lipoproteins in young men and women. Inappropriate vitamin and trace element supplementation may facilitate the development of atherosclerosis. It is known that Vitamin E protects lipids from oxidative stress, while clinical signs of atheroscler...

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  • [The effect of low-protein diet supplemented with ketoacids in patients with chronic renal failure].

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    authors: Molnár M,Szekeresné Izsák M,Nagy J,Figler M

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  • [Two cases of hyperthyroidism and ophthalmopathy following hypothyroidism].

    abstract::Two cases of Graves' disease emerging in previously hypothyroid patients are described. After two years of thyroid hormone substitution due to 'idiopathic' hypothyreosis (patient 1) and Hashimoto's thyroiditis (patient 2), the substitution had to be stopped. The persisting clinical and laboratory signs of immune hyper...

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    doi:

    authors: Kálmán K,Nagy E,Leövey A

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  • [H2-receptor antagonists and alcohol: clinical significance].

    abstract::The aim of the review is to evaluate the putative clinical interactions between alcohol metabolism and the administration of H2-receptor antagonists. Places of the first-pass metabolism of ethanol in the body have been investigated as well. According to the in vitro experimental results the H2-receptor antagonists can...

    journal_title:Orvosi hetilap

    pub_type: 杂志文章,评审

    doi:

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    更新日期:1996-06-16 00:00:00

  • [Transient left ventricular dysfunction: special form of stress cardiomyopathy].

    abstract:INTRODUCTION:The phenomenon of stress induced left ventricular dysfunction has been long recognised. A special reversible form of it, characterized by left ventricular apical dilatation, is the so-called "tako-tsubo" or ampoule cardiomyopathy, based on its first description by Sato et al. in 1990. The tako-tsubo cardio...

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    doi:10.1556/OH.2008.28181

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  • [Study of the canalis mandibulae morphology in different vertical facial types].

    abstract:INTRODUCTION:The precise knowledge of the position of canalis mandibulae and foramen mandibulae is important for surgical and endodontic interventions on the mandible. AIM:The aim of the study is to examine the position of these anatomical landmarks in different vertical facial types. METHOD:In the panorama radiograp...

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