Abstract:
INTRODUCTION:Besides clinicopathological parameters, molecular markers can be very important, and further characterize colorectal carcinomas into chromosomally unstable, microsatellite instable and "CqG-island methylator phenotype" groups. AIM:To study the frequency of microsatellite instability using immunohistochemical evaluation of MLH1, MSH2, MSH6 and PMS2 proteins in colorectal carcinoma. METHOD:122 colorectal carcinomas as well as in 69 paired liver metastases were evaluated. Additionally, prognostic and predictive potential of mismatch repair status was tested. RESULTS:Microsatellite instable phenotype was identified in 11.5% (14/122) of the tumours. There were no differences regarding staining intensity of tumour regions. Mismatch repair status was discordant in primaries vs. metastases in 20.2%. There was no difference in progression free- and overall survival according to mismatch repair status. The mismatch repair status was not predictive for survival within systemic therapy regimen groups. CONCLUSIONS:The subgroups of colorectal carcinomas could be evaluated in a larger and homogenised patient cohort to predict prognosis and response to therapy.
journal_name
Orv Hetiljournal_title
Orvosi hetilapauthors
Ágoston EI,Baranyai Z,Dede K,Bodoky G,Kulka J,Bursics A,Harsányi L,Szász AMdoi
10.1556/650.2015.30218subject
Has Abstractpub_date
2015-09-06 00:00:00pages
1460-71issue
36eissn
0030-6002issn
1788-6120journal_volume
156pub_type
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