Abstract:
UNLABELLED:The effect of supplementary Vitamin E on the vitamin content of lipoproteins in young men and women. Inappropriate vitamin and trace element supplementation may facilitate the development of atherosclerosis. It is known that Vitamin E protects lipids from oxidative stress, while clinical signs of atherosclerosis appear later in women compared to men. AIMS:(1) The increase of vitamin E in plasma and plasma lipoproteins after 4 weeks of supplementation vitamin E was investigated, (2) furthermore it was tested whether a proportion shift occurs in alpha-tocopherol content of lipoproteins, (3) and checked for gender-related differences in plasma and plasma lipoprotein vitamin E levels before, during and after treatment, (4) plasma CRP levels as a marker of lipid peroxidation were also followed. METHODS:5-5 young healthy men and women took part in the study, receiving 700 IU/day Vitamin E for one month. Each subject was studied before and at the end of treatment, and also one month after treatment. HDL and LDL-VLDL containing lipoproteins were separated. Vitamin E and hsCRP levels were measured (by HPLC and an immunoturbidimetric method, respectively). RESULTS:Vitamin E treatment induced in both genders an approximately threefold increase in vitamin E concentration in HDL-cholesterol (8.1 +/- 1.7 micromol/l vs. 22.5 +/- 7.5 micromol/l, p < 0.001), and a twofold increase in LDL-VLDL-cholesterol (22.0 +/- 3.7 micromol/l vs. 49.0 +/- 9.0 micromol/l, p < 0.001). Plasma and HDL vitamin E levels were higher in women than in men at the onset of treatment (6.8 +/- 0.96 micromol/l vs. 9.5 +/- 1.10 micromol/l), but during the treatment these gender-related differences disappeared. When plasma vitamin E concentration were considered 100% and the changes of the vitamin E concentrations of lipoproteins were calculated, it was found that supplementation with vitamin E in men increased the vitamin E concentration of LDL-VLDL cholesterol to a higher extent compared to women (LDL-VLDL % in men: 59.8 +/- 7.43%, in women: 49.3 +/- 7.41%, p < 0.05). All the observed changes regressed one month after cessation of supplementation. The level of hsCRP decreased during vitamin E treatment (1.07 +/- 0.9 mg/l vs. 0.2 +/- 0.14 mg/l, p < 0.001), and remained suppressed after the cessation of treatment (0.37 +/- 0.4, p < 0.01). CONCLUSIONS:These results support the hypothesis that women at young age are better protected against lipid-peroxidation as compared to men because of higher HDL vitamin E concentrations. Vitamin E supplementation in men eliminates this concentration difference between genders, and also increases LDL-VLDL vitamin E. In both genders high concentration of vitamin E in lipoproteins was associated with low hsCRP concentration.
journal_name
Orv Hetiljournal_title
Orvosi hetilapauthors
Somogyi A,Herold M,Kocsis I,Nagy G,Somfai G,Studinger Psubject
Has Abstractpub_date
2005-08-28 00:00:00pages
1813-8issue
35eissn
0030-6002issn
1788-6120journal_volume
146pub_type
临床试验,杂志文章相关文献
ORVOSI HETILAP文献大全abstract::During the last years, interventional radiological treatment of hepatocellular cancer has changed dramatically. The percutaneous ethanol infiltration is partly replaced by thermoablative methods, mainly by radiofrequency ablation. Cooled-tip electrodes and volumetric therapy planning increased the treatment success. E...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/OH.2010.28914
更新日期:2010-07-25 00:00:00
abstract::Patients seeking help from gastroenterologist have frequent complaints of changes in the quality and quantity of stool as well in the frequency of bowel movements. Definition of diarrhea includes: more than three bowel movements daily, more than 200 grams of the stool daily, and its water content exceeding 75-85%. Dia...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/OH.2009.28709
更新日期:2009-08-30 00:00:00
abstract::Neutral endopeptidase (neprilysin; EC 3.4.24.11) is present in the brush border membrane, for example in the bile ducts. We investigated serum neprilysin activity and its correlation with cholestatic markers in patients with primary biliary cirrhosis. Sera of 39 patients with primary biliary cirrhosis (37 females, 2 m...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2000-04-30 00:00:00
abstract::This article reviews the recent changes in the understanding of acute pancreatitis pathophysiology emphasizing results deriving from the more detailed comprehension of the local and systemic aspects of the inflammatory process. The authors briefly discuss those theories that have been influencing the basic philosophie...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:2000-02-06 00:00:00
abstract::The goal of stereotactic radiosurgery by definition is "the delivery of a single, high dose of radiation allowing the precise and complete destruction of chosen target structures containing healthy and/or pathological cells, without significant concomitant or late radiation damage to adjacent tissues". This effect is ...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:2001-10-07 00:00:00
abstract:BACKGROUND AND AIMS:Interferon-alfa (IFN-alfa) has recently been introduced for chronic C hepatitis treatment; however, the response rate is merely 25-50%. The aims of this follow-up study were to compare the efficacy of 6 and 12-month IFN-alfa treatment via liver biopsy scores and to evaluate the correlation with the ...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:1998-04-12 00:00:00
abstract::The authors investigated the frequency of left atrial spontaneous echo contrast in mitral valve disease. They also tested whether there was any correlation between the presence of left atrial spontaneous echo contrast and the severity of the mitral valve disease. Echocardiographic investigations were performed using b...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1996-12-01 00:00:00
abstract:INTRODUCTION:Informal care plays an important role in ageing societies. AIM:To analyse informal care use and its determinants among patients with chronic diseases in Hungary. METHOD:Patient level data from previous studies in 14 diagnoses were analysed including patients' EQ-5D-3L health status. Descriptive statistic...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2017.30894
更新日期:2017-12-01 00:00:00
abstract::Williams syndrome is a rare genetic disorder, that occurs equally in all ethnic groups and both sexes. The diagnosis might be missed during childhood in mild cases. However, establishing the diagnosis is important, not only to find the cause of intellectual disability but to look for cardiovascular, endocrine, psychia...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2017.30905
更新日期:2017-11-01 00:00:00
abstract::The authors review the theories of origin of the so-called sclerosing heamangioma of the lung. The results of immunohistochemical studies--epithelial membrane antigen positivity and vimentin and factor VIII. related antigen negativity--support the hypothesis of epithelial origin. The problems of clinical and pathologi...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1994-01-16 00:00:00
abstract::During the first 3 months of the full-time lactation the level of the lipid and lipoprotein fractions does not change in the mother's blood. The levonorgestrel contraceptive pills taken during the lactation do not influence considerably the lipid-metabolism either. There is only one minute deviation in the levonorgest...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1992-02-09 00:00:00
abstract::The article summarises the statistical data of bone marrow transplantation (BMT) carried out in Hungary between 1990-1995 in yearly distribution. Since the first BMT up to the end of 1995, 168 BMT were performed. The number of transplantations since 1990 to our days was gradually increasing. As a result of this activi...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1996-10-06 00:00:00
abstract::The case history of a 49-year-old female patient is reported, who was operated on because of varicose vein in the left lower extremity. A few days after the operation serious signs of cerebrovascular insult appeared. The clinical picture and the result of an urgent transoesophageal echocardiography are described; a se...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2000-07-02 00:00:00
abstract:UNLABELLED:INTRODUCTION, AIMS: In spring of 2000 a national survey was conducted on the diagnostic and therapeutic attitudes of Hungarian family practitioners concerning Helicobacter pylori. RESULTS:Based on responses, endoscopy, urea breath test and serology are easily available to 98, 42 and 48% of family practition...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2002-06-30 00:00:00
abstract::Acute porphyrias are caused by the inherited decreased activity of the enzymes of the heme biosynthesis pathway. Depending on the affected enzyme there are 4 types of them: acute intermittent porphyria, porphyria variegata, coproporphyria and delta-aminolevulinic acid dehydratase deficient porphyria, listed in order o...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:2003-05-11 00:00:00
abstract::Introduction: For the treatment of asymmetry of the midface due to permanent peripheral facial nerve palsy of different etiologies - which means a great psychical burden for the patients - several surgical solutions have been described. Aim: Our goal was to elaborate a minimally invasive surgical technique, that, on o...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2019.31344
更新日期:2019-06-01 00:00:00
abstract:UNLABELLED:In a retrospective evaluation, the outcome of the long term treatment of the sphincter of Oddi dyskinesia (OD, type III. dysfunction) has been analysed. PATIENTS AND METHOD:Therapeutic results of 64 cholecystectomised patients with OD were evaluated by means of regular follow-up and questionnaire filled in ...
journal_title:Orvosi hetilap
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1995-10-01 00:00:00
abstract::In the past few years more and more data have become available on the important role of vitamin D in immunological processes and inflammation. The role of vitamin D deficiency in the pathogenesis as well as in disease progression of different autoimmune and inflammatory conditions is suspected. Vitamin D deficiency is...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/650.2017.30816
更新日期:2017-08-01 00:00:00
abstract::Following the failure of conventional diagnostic procedures, whole-body FDG-PET investigations were carried out in 42 metastatic cancer patients to localize occult primary carcinomas. During the clinical follow-up, the presence of malignant tumor was ruled out in 3 cases, and 2 patients originally believed to have car...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2002-05-26 00:00:00
abstract::The authors present a case of a young diabetic patient with acute symptoms of pyelonephritis. The specific and permanent antibiotic treatment was ineffective and septic condition developed complicated by renal papillary necrosis. Because of the strong flank pain extensive examinations were done with negative result. T...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2001-03-25 00:00:00
abstract::Age-related changes in renal morphology and function cannot be regarded physiological. The number of glomeruli falls, sclerotic glomeruli and aglomerular arterioles develop. Besides tubular atrophy interstitial fibrosis is often seen, and the age-related vascular changes strongly affect the kidneys. Renal blood flow a...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/OH.2008.28362
更新日期:2008-04-27 00:00:00
abstract::Introduction: Autologous hemopoietic stem cell transplantation remains a promising therapy in certain malignant and non-malignant conditions. The procedure, however, will increase the risk of complications, most notably early and late infections. Aim: To analyze the frequency and spectrum of pathogens in early (<+100 ...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2020.31638
更新日期:2020-01-01 00:00:00
abstract::The authors present a case report of a 13.5 yrs old girl. The first manifestation of her diabetes was the sudden decrease of her vision due to bilateral cataract. There was no report of perinatal of actual infection, previous trauma, radiation exposure or drug consumption. She was hypermetropic, for that she regularly...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:1999-08-29 00:00:00
abstract::The healing properties of sunlight has been known for millennia, however the gradual deterioration of the ozone layer and the increased use of sun tanning beds in recent decades are causing an increase in skin damaging ultraviolet exposure. In this article the most common photodermatoses and the principles of their tr...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/650.2016.30335
更新日期:2016-01-17 00:00:00
abstract::Invasive prenatal testing and conventional G-banding chromosome analysis have been considered to be the gold standard of fetal cytogenetic diagnosis. Standard karyotyping is, however, constrained by the limits of the resolution of using a microscope. The advantage of molecular karyotyping, array based methods is the e...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:10.1556/650.2019.31322
更新日期:2019-03-01 00:00:00
abstract::In the androgen insensitivity syndrome (AIS) the androgen effect is decreased in the fetus and the youth despite the adequate testosterone production. Usually the mutation of the androgen receptor is responsible for the disease. In the presented case the external genitalia were similar to female genitalia but masses w...
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:
更新日期:2006-09-17 00:00:00
abstract::The prevalence of allergic diseases has been increasing recently. Allergy has various symptoms. Allergic eye diseases (seasonal and perennial allergic conjunctivitis, vernal keratoconjunctivitis, atopic keratoconjunctivitis, giant papillary conjunctivitis, contact blepharoconjunctivitis) are common in atopic patients....
journal_title:Orvosi hetilap
pub_type: 杂志文章
doi:10.1556/650.2019.31265
更新日期:2019-03-01 00:00:00
abstract::Ghrelin: a new peptide regulating the neurohormonal system and energy homeostasis. Research leading to the identification of ghrelin started with the discovery of growth hormone secretagogues, continued with the description of ghrelin receptors and ended with description of the chemical structure of ghrelin. However, ...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:2004-12-19 00:00:00
abstract::Authors surveyed the data of 2677 patients with acute myocardial infarction treated in cardiological department between 1970 and 1993. Activity of Coronary Care Unit (has been working from 1974) reduced the earlier hospital mortality in general internal medicine possibilities with 50%. Main cause of this reduction was...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:1995-06-18 00:00:00
abstract::Proton pump inhibitors (PPI) have influenced dramatically the management of acid-related disorders in recent years. They all have a broadly similar mechanism of action. There are some differences however, between the PPIs in their pharmacokinetics, pharmacodynamics, clinical efficacy, and potential for drug interactio...
journal_title:Orvosi hetilap
pub_type: 杂志文章,评审
doi:
更新日期:2001-09-09 00:00:00