[Complex analysis of prognostic factors in chronic lymphocytic leukemia].

Abstract:

INTRODUCTION:Many new prognostic factors established in recent years in chronic lymphocytic leukemia. May help predicting survival. AIMS:The goal of the present study was to determine the frequency and the correlation of these novel prognostic factors in samples of 419 leukemia patients. METHODS:The mutation status of the IgH gene was evaluated in 160 cases. RESULTS:In 62% of cases, non-mutated IgH gene was found, the heavy chain family usage was different in mutated and non-mutated cases. The CD38 expression demonstrated 78% concordance with the mutation status, the ZAP-70 expression failed to show any correlation. Cytogenetic abnormalities were seen in 76% of cases, the most frequent were del(13q) (57%), trisomy 12 (15%), del(11q) (12%) and del(17p) (6%). 95% of cases with del(11q) harbored non-mutated, 74% of cases with del(13q) as the sole anomaly demonstrated mutated IgH genes. CONCLUSIONS:The parameters analysed are not independent of each other, utilization of them in the clinical routine needs careful planning.

journal_name

Orv Hetil

journal_title

Orvosi hetilap

authors

Kajtár B,Jáksó P,Kereskai L,Lacza A,Méhes G,Bodnár MA,Dombi JP,Gasztonyi Z,Egyed M,Iványi JL,Kovács G,Marton E,Palaczki A,Petz S,Tóth P,Sziládi E,Losonczy H,Pajor L

doi

10.1556/OH.2007.27943

subject

Has Abstract

pub_date

2007-04-22 00:00:00

pages

737-43

issue

16

eissn

0030-6002

issn

1788-6120

pii

976004334J235M17

journal_volume

148

pub_type

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