[Vitamin D receptor gene polymorphisms and risk of hip fracture in Chilean elderly women].

Abstract:

BACKGROUND:Osteoporotic hip fractures are devastating events in older women. There is a genetic modulation of bone phenotypic parameters including bone density (BMD) and bone fragility fractures. Vitamin D receptor (VDR) gene polymorphisms explain a small part of the genetic influence on BMD, whereas their effect on fractures remains uncertain. AIM:To examine the contributions of VDR genotypes to the susceptibility to hip fracture in elderly Chilean women. PATIENTS AND METHODS:We recruited 126 women (67 with fractures and 59 without) from Bio-Bio Region, Chile, aged 65 to 94 years. Genotyping for Bsm-l, Apa-1, Taq-1 and Fok-1 VDR polymorphisms was performed using polymerase chain reaction methods. All hip fractures were confirmed by X-ray. RESULTS:The allele frequencies were 0.49 for B, 0.57 for A, 0.60 for T and 0.65 for F in the Bsm-l, Apa-1, Taq-1 and Fok-1 polymorphisms respectively. The prevalence of these VDR gene polymorphisms in women with fractures were 16% BB, 69% Bb, 15% bb for Bsm-l; 30% AA, 46% Aa, 14% aa for Apa-1; 17% TT, 34 Tt, 8% tt for Taq-1 and 43%FF, 41% Ff, 16% ff for Fok-1. All VDR genotype frequencies did not differ from Hardy-Weinberg expectations. Allele or genotype frequencies did not differ between women with or without fractures. These results did not change when analysis was adjusted by age weight, height or gynecologic history. CONCLUSIONS:The genotype frequencies of the VDR polymorphisms are in accordance with the frequencies of other Hispanic and Caucasian populations. Our results suggest that VDR polymorphisms are not associated with the risk of hip fracture in older women of this Region of Southern Chile.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Quevedo L I,Martínez B M,Castillo N M,Rivera F N

doi

/S0034-98872008000400008

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

475-81

issue

4

eissn

0034-9887

issn

0717-6163

pii

S0034-98872008000400008

journal_volume

136

pub_type

杂志文章
  • [The medical history of Edgar Allan Poe].

    abstract::Edgar Allan Poe, one of the best American storytellers and poets, suffered an episodic behaviour disorder partially triggered by alcohol and opiate use. Much confusion still exists about the last days of his turbulent life and the cause of his death at an early age. Different etiologies have been proposed to explain h...

    journal_title:Revista medica de Chile

    pub_type: 传,历史文章,杂志文章

    doi:10.4067/s0034-98872007000900019

    authors: Miranda C M

    更新日期:2007-09-01 00:00:00

  • [Genetic polymorphism of isoniazid acetylation in Chilean patients with tuberculosis].

    abstract::We studied genetic polymorphism of isoniazid acetylation in 47 tuberculous patients treated with 4 drugs between Aug 1987 and Dec 1988. Inactivation of isoniazid was estimated from urine samples after administration of the drug (10 mg/kg). There were 18 slow and 29 fast acetylators. The frequency of the slow mutant ge...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Ligueros M,Cruz Coke R,Neira S,Saavedra H,Kramer V,Prieto JC,Gelman M,Saavedra A,Nuñez A,Pescio S

    更新日期:1989-12-01 00:00:00

  • [Lithogenic risk in patients from Paraguay with urolithiasis].

    abstract:UNLABELLED:The lithogenic risk profile is a graphical representation of metabolic factors and urinary saturation involved in the stone formation with their respective critical values. AIM:To determine the lithogenic risk profile in patients with urolithiasis. MATERIAL AND METHODS:Personal data such as anthropometric,...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872016000600005

    authors: Funes P,Echagüe G,Ruiz I,Rivas L,Zenteno J,Guillén R

    更新日期:2016-06-01 00:00:00

  • [Wolff-Parkinson-White syndrome: late results of surgical treatment].

    abstract::We followed 25 patients operated on for Wolff-Parkinson-White syndrome between August 1985 and October 1989. Their mean age was 37 +/- 12 years and arrhythmia had been present for 5 to 30 years. A mean of 3.3 +/- 1.2 antiarrhythmic agents had failed in controlling recurrences. Tachycardia was orthodromic in 21 patient...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: González R,Morán S,Fajuri A,Irarrazabal MJ,Maturana G,Urzua J,Lema G,Espinoza R,Casanegra P

    更新日期:1990-08-01 00:00:00

  • [Association of the TCF7L2 (RS7903146) genotype with adiposity and metabolic markers in the Chilean adult population].

    abstract:BACKGROUND:Type 2 diabetes etiology has a strong genetic component. More than 20 genetic variants have been associated with diabetes and other metabolic markers. However, the polymorphism rs7903146 of the TCF7L2 gene has shown the strongest association. AIM:To investigate the association of TCF7L2 (rs7903146) genotype...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872019000800965

    authors: Petermann-Rocha F,Lasserre-Laso N,Villagrán M,Mardones L,Martínez MA,Leiva AM,Ulloa N,Celis-Morales C

    更新日期:2019-08-01 00:00:00

  • [Legal recognition of transsexuality in Chile through the judicial procedure for name change].

    abstract::Do transsexual people in Chile have a right to have their gender identity or their sex reassignment legally recognized? The absence of any legislation on gender identity or transsexualism could lead us to believe that it is not the case. However, a quantitative review of decisions issued by Chilean courts during the l...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872015000800008

    authors: Muñoz León F

    更新日期:2015-08-01 00:00:00

  • [IgG4 associated nephritis and recurrent hemoptysis: Case report].

    abstract::IgG4 disease is a multi-systemic condition involving pancreas, salivary glands and lymph nodes. Less frequently, it causes interstitial nephritis and involves the lungs. We report a 58 years old male with a four years history of hemoptysis and renal dysfunction characterized by hematuria and proteinuria, responsive to...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872017000100018

    authors: Erlij D,Rivera Á,Maya JC,Cuellar C,Correa G,Michalland S,Méndez GP

    更新日期:2017-01-01 00:00:00

  • [Inactivation of tumor suppressor genes in uterine cervix carcinogenesis].

    abstract::The importance of inactivation of tumor suppressor genes in the development/progression of carcinomas of the uterine cervix is reviewed. It is well known that HPV-related oncogenes are strongly linked to cervical cancer. However, fewer studies have explored the occurrence of inactivation of tumor suppressor genes in t...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:

    authors: Chuaqui R,Cuello M,Emmert-Buck M

    更新日期:1999-12-01 00:00:00

  • [Non-specific cecal ulcer in a patient with chronic renal failure in hemodialysis treatment. Case report].

    abstract::We report a 65 years old female undergoing hemodialysis, presenting with intense pain in the lower right quadrant and moderate hematochezia. Since symptoms did not abate after an appendectomy, a colonoscopy and barium enema were performed, whose results suggested an advanced cecal carcinoma. Biopsies were negative for...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Bannura G,Melo C,Villamán J,Muñoz M,Levy I

    更新日期:1999-05-01 00:00:00

  • [Antihypertensive effects of valsartan. National multicentric study].

    abstract:BACKGROUND:Valsartan is an angiotensin AT1 receptor antagonist. Clinical studies have shown that this is an effective and well tolerated drug. AIM:To compare valsartan with other commonly used antihypertensives in a National multicentric study. MATERIAL AND METHODS:Between 1997 and 1998, a pharmacological surveillanc...

    journal_title:Revista medica de Chile

    pub_type: 临床试验,杂志文章,多中心研究

    doi:

    authors: Prat H

    更新日期:2000-05-01 00:00:00

  • [A workshop to improve written communication skills of medical students].

    abstract:BACKGROUND:Despite being among the best academically prepared of the country, many medical students have difficulties to communicate in writing. In 2005, the School of Medicine at the Pontificia Universidad Católica de Chile introduced a writing workshop in the undergraduate curriculum, to enhance the students' writing...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872009000500004

    authors: Bitran M,Zúñiga D,Flotts P,Padilla O,Moreno R

    更新日期:2009-05-01 00:00:00

  • [SPECT tomography with F 18-fluorodeoxyglucose in a recent myocardial infarction clinical case].

    abstract::We report a 50-year-old woman with a recent myocardial infarction in whom a myocardial perfusion single photon emission computed tomography (SPECT) with Thallium201 was done simultaneously with a F18-fluorodeoxyglucose (FDG) SPECT to study glucose metabolism. Myocardial infarction was located in the anteroseptal and a...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: González P,Coll C,Massardo T,Sierralta P,Humeres P,Aramburú I,Brugère S,Yovanevich J,Ramírez A,Jofré J,Chamorro H,Kuntsmann S,López H

    更新日期:2000-09-01 00:00:00

  • [Cholesterol and triglycerides in atherosclerosis: epidemiologic and physiopathologic considerations].

    abstract::Increased cholesterol levels above 200 mg/dl, LDL levels above 130 mg/dl and total cholesterol/HDL ratio above 4.5 in males and above 5.0 in females are recognized as indicators of increased risk of atherosclerosis. Risk associated to increased triglyceride levels (above 200 mg/dl) must be judged in relation to associ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:

    authors: Davidoff P

    更新日期:1991-09-01 00:00:00

  • [Systemic inflammatory response syndrome: is it comparable with severe sepsis?].

    abstract:BACKGROUND:In 1992, a consensus conference defined the terms systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis and septic shock. Since then, numerous reports have validated the prognostic usefulness of these operative definitions. AIM:To evaluate if sepsis severity criteria, as defined by the Conse...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Hernández G,Dougnac A,Castro J,Labarca E,Ojeda M,Bugedo G,Castillo L,Andresen M,Bruhn A,Huidobro LF,Huidobro R,Caballero MT,Hernández A

    更新日期:1999-11-01 00:00:00

  • [Influence of personality and learning styles in the choice of medical specialty].

    abstract:BACKGROUND:Several studies indicate that doctors who work in the same area of the medical profession tend to behave somehow similarly. Thus, it has been suggested that personality relates to the medical specialty choice. However, it is not known whether people self-select into the medical specialties according to their...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/s0034-98872005001000008

    authors: Bitran M,Zúñiga D,Lafuente M,Viviani P,Mena B

    更新日期:2005-10-01 00:00:00

  • [Primary adrenal insufficiency due to autoimmune adrenalitis].

    abstract::We report a 10 years old boy, admitted with a history of asthenia, anorexia and weight loss of 4 kg. Initial laboratory work up showed metabolic acidosis and hyponatremia. The patient had no circadian rhythm of serum cortisol and an adrenal stimulation test confirmed the presence of adrenal insufficiency. Anti-adrenal...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Muzzo S,Izquierdo G,Verbeke S

    更新日期:2002-08-01 00:00:00

  • [Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis: advances in pathogenesis and treatment].

    abstract::ANCA (anti-neutrophil cytoplasmic antibodies) associated vasculitis or AAV are a group of diseases with predominant inflammation of small vessels and the presence of detectable ANCA in serum. Due to these common features, it is considered that AAV share pathogenic mechanisms. Consequently, a similar therapeutic approa...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:10.4067/S0034-98872013000600011

    authors: Silva F,Cisternas M

    更新日期:2013-06-01 00:00:00

  • [Microdeletion of Y chromosome in severe olygozoospemic infertile patient].

    abstract::We are reporting a 37 year old male with severe oligozoospermia and a history of infertility for thirteen years and surgery for severe unilateral varicocele. The hormonal levels for FSH, LH and T, and karyotype were within the normal range. Multiplex PCR revealed the presence of a de novo microdeletion in the azoosper...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Castro A,López P,Johnson MC,Sovino H,Martínez C,Vantman D

    更新日期:2000-07-01 00:00:00

  • [Effects of a six weeks exercise training program for type 2 diabetes mellitus and hypertensive patients].

    abstract:BACKGROUND:There is a wide interindividual variability in the response to a period of exercise training. The science have reported that a minimum of participants could be non-responders for improving different health-related outcomes after training. AIM:To compare the effects of a 6-weeks exercise program on body comp...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/s0034-98872018000600693

    authors: Cano-Montoya J,Ramírez-Campillo R,Sade Calles F,Izquierdo M,Fritz Silva N,Arteaga San Martín R,Álvarez C

    更新日期:2018-06-01 00:00:00

  • [Clinical usefulness of rheumatoid factor in synovial fluid. Re-evaluation].

    abstract::The aim of this work is to analyze the usefulness of rheumatoid factor determination in synovial fluid. One hundred twenty nine patients (29 with rheumatoid arthritis), in whom rheumatoid factor was simultaneously determined in serum and synovial fluid, were retrospectively analyzed. Serum rheumatoid factor had a 48% ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Sari L,Astorga G,Carvajal P,Gatica H

    更新日期:1993-12-01 00:00:00

  • [Use of intravenous immunoglobulin for the treatment of toxic epidermal necrolysis and Stevens-Johnson/toxic epidermal necrolysis overlap syndrome. Review of 15 cases].

    abstract:BACKGROUND:Toxic epidemial necrolysis (TEN) is an acute adverse drug reaction, that has an unpredictableprogression and a 30% mortality. The incidence of TEN in the general population is approximately 0.4 to 1.2 cases/million/year. It is characterized pathologically by keratinocyte apoptosis which leads to epidemial de...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872009000300009

    authors: Molgó M,Carreño N,Hoyos-Bachiloglu R,Andresen M,González S

    更新日期:2009-03-01 00:00:00

  • [Andrés Bello and medical education].

    abstract::Andrés Bello, a Venezuelan intellectual arrived in Chile in 1829. He had a decisive influence on the development of natural sciences and medical sciences in this country. The first formal teaching program in Medicine appeared in 1833, with few students due to the low social prestige of Medicine at that time. The Facul...

    journal_title:Revista medica de Chile

    pub_type: 传,历史文章,杂志文章

    doi:

    authors: Costa-Casaretto C

    更新日期:1991-11-01 00:00:00

  • [Aortic valve replacement with bioprosthesis in patients 70 years old or older with aortic stenosis].

    abstract:BACKGROUND:Aortic valve stenosis is the most prevalent valvulopathy in the elderly, but it is frequently undertreated. AIM:To assess early and long term results of valve replacement with bioprostheses in patients 70 years old or older with aortic stenosis. PATIENTS AND METHODS:A review of the database of the Cardiova...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872011000200002

    authors: Zalaquett R,Olivares G,Mejía R,Quezada F,Padilla O,Becker P,Irarrázaval M,Morán S,Muñoz C,González R

    更新日期:2011-02-01 00:00:00

  • [Association of Good syndrome with pure red cell aplasia: report of one case].

    abstract::The association between Good's syndrome (hypogammaglobulinemia and thymoma) with pure red aplasia is very uncommon. We report a 70-year-old male, who had a thymoma excised nine years before. Afterwards, he suffered frequent respiratory infections, which were attributed to a humoral immunodeficiency. Nine years later, ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:10.4067/S0034-98872012000800013

    authors: Peña C,Intriago M,Muñoz P,Gray AM,Cabrera ME

    更新日期:2012-08-01 00:00:00

  • [Seroprevalence of Epstein Barr virus infection in a healthy population of Santiago de Chile].

    abstract::To study the rate of infection by Epstein Barr virus (EBV) in Santiago, Chile, the prevalence of antibody to the viral capsid antigen (VCA-IgG) was determined in a group of 663 healthy individuals grouped by age and socioeconomic level (SEL). In addition, several risk factors for infection were studied. VCA-IgG was de...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Ferrés M,Prado P,Ovalle J,Fuentes R,Villarroel L,Ferreccio C,Vial P

    更新日期:1995-12-01 00:00:00

  • [Sun exposure behaviors and knowledge among Chileans].

    abstract:BACKGROUND:Ultraviolet light exposure has a pathogenic effect on the development of skin cancer, whose prevalence increases worldwide. In Chile and the rest of the world, preventive educational campaigns are carried out to change high risk sun exposure behaviors. AIM:To study the behavior of the Chilean population tow...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872005000600007

    authors: Molgó M,Castillo C,Valdés R,Romero W,Jeanneret V,Cevo T,Torres C,Silva P,Flores L,Riquelme A,Ayala MF,González F,Hasbún MT,Baladrón MJ

    更新日期:2005-06-01 00:00:00

  • [Antimicrobial activity of actinomycetes isolated from aquatic environments in southern Chile].

    abstract:BACKGROUND:The easy access and inappropriate use of antimicrobials led to selection and spread of resistant microorganisms strains. It is imperative to search for new and more effective antimicrobials. One strategy is the screening of metabolites produced by microorganisms found in the environment. Actinomycetes are a ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/s0034-98872004000200003

    authors: Leiva S,Yáñez M,Zaror L,Rodríguez H,García-Quintana H

    更新日期:2004-02-01 00:00:00

  • [Effect of chronic blockade of the opiodergic receptor on insulin resistance in a hyperandrogenic woman].

    abstract::We report a woman with insulin resistance associated with hyperandrogenism and acanthosis nigricans (HAIR-AN syndrome) treated during 30 days with the prolonged action opioid antagonist Naltrexone. During its administration, decreases in basal blood glucose and serum insulin, insulin and glucose response to a glucose ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Sir T,López G,Alba F,Cipriano A,Candía M,Castillo T,Devoto L

    更新日期:1994-04-01 00:00:00

  • [Primary hyperthyroidism after excision of a Struma ovarii].

    abstract::Struma ovarii is a teratoma composed of thyroid tissue and can be a rare cause of hyperthyroidism. We report a 35 years old woman with a left ovarian mass whose pathology revealed a Struma ovarii. This tumor was partially excised initially to avoid fertility problems and after a successful gestation, the tumor was com...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Sapunar J,Roa JC,Meissner A

    更新日期:2003-07-01 00:00:00

  • [Etiology and biomarkers of systemic inflammation in mild to moderate COPD exacerbations].

    abstract:BACKGROUND:The etiology of acute exacerbations of chronic obstructive pulmonary disease (COPD) is heterogeneous and still under discussion. Inflammation increases during exacerbation of COPD. The identification of inflammatory changes will increase our knowledge and potentially guide therapy. AIM:To identify which inf...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872012000100002

    authors: Saldías PF,Díaz PO,Dreyse DJ,Gaggero BA,Sandoval AC,Lisboa BC

    更新日期:2012-01-01 00:00:00