Abstract:
BACKGROUND:Osteoporotic hip fractures are devastating events in older women. There is a genetic modulation of bone phenotypic parameters including bone density (BMD) and bone fragility fractures. Vitamin D receptor (VDR) gene polymorphisms explain a small part of the genetic influence on BMD, whereas their effect on fractures remains uncertain. AIM:To examine the contributions of VDR genotypes to the susceptibility to hip fracture in elderly Chilean women. PATIENTS AND METHODS:We recruited 126 women (67 with fractures and 59 without) from Bio-Bio Region, Chile, aged 65 to 94 years. Genotyping for Bsm-l, Apa-1, Taq-1 and Fok-1 VDR polymorphisms was performed using polymerase chain reaction methods. All hip fractures were confirmed by X-ray. RESULTS:The allele frequencies were 0.49 for B, 0.57 for A, 0.60 for T and 0.65 for F in the Bsm-l, Apa-1, Taq-1 and Fok-1 polymorphisms respectively. The prevalence of these VDR gene polymorphisms in women with fractures were 16% BB, 69% Bb, 15% bb for Bsm-l; 30% AA, 46% Aa, 14% aa for Apa-1; 17% TT, 34 Tt, 8% tt for Taq-1 and 43%FF, 41% Ff, 16% ff for Fok-1. All VDR genotype frequencies did not differ from Hardy-Weinberg expectations. Allele or genotype frequencies did not differ between women with or without fractures. These results did not change when analysis was adjusted by age weight, height or gynecologic history. CONCLUSIONS:The genotype frequencies of the VDR polymorphisms are in accordance with the frequencies of other Hispanic and Caucasian populations. Our results suggest that VDR polymorphisms are not associated with the risk of hip fracture in older women of this Region of Southern Chile.
journal_name
Rev Med Chiljournal_title
Revista medica de Chileauthors
Quevedo L I,Martínez B M,Castillo N M,Rivera F Ndoi
/S0034-98872008000400008subject
Has Abstractpub_date
2008-04-01 00:00:00pages
475-81issue
4eissn
0034-9887issn
0717-6163pii
S0034-98872008000400008journal_volume
136pub_type
杂志文章abstract::Edgar Allan Poe, one of the best American storytellers and poets, suffered an episodic behaviour disorder partially triggered by alcohol and opiate use. Much confusion still exists about the last days of his turbulent life and the cause of his death at an early age. Different etiologies have been proposed to explain h...
journal_title:Revista medica de Chile
pub_type: 传,历史文章,杂志文章
doi:10.4067/s0034-98872007000900019
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journal_title:Revista medica de Chile
pub_type: 杂志文章
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journal_title:Revista medica de Chile
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journal_title:Revista medica de Chile
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journal_title:Revista medica de Chile
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journal_title:Revista medica de Chile
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journal_title:Revista medica de Chile
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