Influences of the early olfactory environment on the survival, behavior and pituitary-adrenal activity of caesarean delivered preterm rat pups.

Abstract:

:In a first experiment, vaginally delivered Day 21 and Caesarean delivered Day 20 and Day 21 rat pups were isolated in the presence of various odorants or no odorant for 1 hr immediately following birth. For Day 20 pups, exposure to novel mint odor resulted in higher mortality during isolation than did exposure to the odor of amnion/placenta. In the preterm pups, whole body corticosterone levels were higher in all isolation treatments than they were immediately following birth. For Day 21 pups, isolation treatments had no effect on corticosterone concentrations, but overall, corticosterone levels were higher following Caesarean section than they were following vaginal delivery. A second experiment replicated the mint odor-induced increase in mortality and revealed a lower activity level in preterm pups exposed to mint odor than in those exposed to the odor of amnion/placenta. Mechanical movement of the pups during exposure eliminated the effects of mint odor on mortality and activity. There was a positive correlation between corticosterone concentrations and pup activity during isolation. These results demonstrate potent influences of seemingly minor changes in early sensory stimulation on the preterm pup. The paradigm might provide a useful animal model for studying the effects of variations in ambient stimulation on premature infants.

journal_name

Dev Psychobiol

authors

Smotherman WP,Robinson SR,La Vallee PA,Hennessy MB

doi

10.1002/dev.420200406

subject

Has Abstract

pub_date

1987-07-01 00:00:00

pages

415-23

issue

4

eissn

0012-1630

issn

1098-2302

journal_volume

20

pub_type

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