Abstract:
:Links between child maltreatment and low-grade inflammation in adulthood are well documented, but these studies often rely on adults to report retrospectively on experiences of childhood abuse. Furthermore, these findings raise questions about whether exposure to childhood maltreatment needs time to "incubate," only giving rise to nonresolving inflammation in adulthood, or whether heightened inflammation may be observable in childhood, closer in time to the maltreatment exposure. The present study examined this question in a sample of 155 low-income children (ages 8-12), half of whom had been exposed to maltreatment. Trained coders evaluated case reports to classify maltreatment based on timing and exposure type. Blood samples from children assessed C-reactive protein and cytokines, which were used to form a composite of low-grade inflammation. Analyses revealed a marginally significant Maltreatment Exposure × Sex interaction, which suggested that maltreatment exposure was associated with higher inflammation for girls but not boys. Additionally, analyses focused on the accumulation of maltreatment experiences (through multiple forms of maltreatment or across multiple time points) revealed that girls with greater diversity in their maltreatment experiences and those who experienced maltreatment at multiple time points were at greatest risk. Finally, examination of timing of first onset of maltreatment suggested that girls whose exposures occurred before the age of 5 had the highest low-grade inflammation. These findings add new evidence linking maltreatment to inflammation in childhood, which could increase the risk for mental and physical health problems across the lifespan.
journal_name
Dev Psychobioljournal_title
Developmental psychobiologyauthors
Ehrlich KB,Miller GE,Rogosch FA,Cicchetti Ddoi
10.1002/dev.22031subject
Has Abstractpub_date
2020-09-08 00:00:00eissn
0012-1630issn
1098-2302pub_type
杂志文章abstract::Two experiments examined in 5- and 10-day-old rat pups the impact of alcohol olfactory aversions upon subsequent alcohol intake. In Experiment 1 it was observed that at both ages, animals given a single pairing of alcohol odor and LiCl subsequently consumed less alcohol than those in any of 4 control conditions (alcoh...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420190304
更新日期:1986-05-01 00:00:00
abstract::The present study was designed to investigate cocaine self-administration in adult male and female rats exposed prenatally to morphine. Pregnant dams were injected two times a day with either saline, analgesic doses of morphine or no drug at all (controls) on gestation Days 11-18. One day after birth, litters were cro...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20240
更新日期:2007-07-01 00:00:00
abstract::Hofer, Brunelli, Shair, and Masmela (2001) examined several behavioral and physiological measures in low, high, and unselected lines obtained from a divergent selection for ultrasound production (USP) in young rats. Although the response to selection was clear-cut, few correlated responses appeared. This surprising re...
journal_title:Developmental psychobiology
pub_type: 评论,信件
doi:10.1002/dev.1002
更新日期:2001-12-01 00:00:00
abstract::The goal of this study was to evaluate lateral preferences in a population of children with intellectual deficiency of idiopathic origin, compared with those of typically developing (TD) children. Two groups of children with mild or moderate intellectual deficiency were observed. Handedness (using a 10-item test and B...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20167
更新日期:2006-09-01 00:00:00
abstract::Intensive corticosterone treatment given to rats during the 1st postnatal week irreversibly decreases DNA accumulation in the cerebrum and cerebellum. After such hypercorticism in infancy rats were tested as adults in 2 conditioned active avoidance tasks. In comparison with litter-mate controls, the treated rats were ...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420080108
更新日期:1975-01-01 00:00:00
abstract::Early theoretical work by Buss (1986a, 1986b) posited that there is an early-developing fearful shyness that emerges during toddlerhood, and a later-developing self-conscious shyness that emerges during early childhood. It has been theorized that early-developing shyness is related to fear, rooted in inherited biases,...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21937
更新日期:2020-07-01 00:00:00
abstract::The present study measured postnatal ultrasonic vocalization (USV) and gene expression to examine potential changes in communication and/or attachment in the offspring of mothers exposed to morphine during adolescence. Offspring of morphine-exposed (Mor-F1), saline-exposed (Sal-F1), or non-handled control (Con-F1) fem...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21411
更新日期:2016-09-01 00:00:00
abstract::This article reviews 30 years of work demonstrating that interactions between mother and newborn infant in the period just after birth influence the physiology and behavior of both. Close body contact of the infant with his/her mother helps regulate the newborn's temperature, energy conservation, acid-base balance, ad...
journal_title:Developmental psychobiology
pub_type: 杂志文章,评审
doi:10.1002/dev.20094
更新日期:2005-11-01 00:00:00
abstract::Adolescence is a time involving a series of changes in the use of appetitive reinforcers like food, as well as neuroendocrine changes like those taking place in the mesolimbic dopamine function. Social isolation from postnatal day 21 to 36 in rats leads to behavioral and neurophysiological alterations such as increase...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21273
更新日期:2015-03-01 00:00:00
abstract::Brain monoaminergic neurotransmitters, such as dopamine (DA), serotonin (5-HT), and noradrenaline (NA), play crucial roles in neuronal and physiological functions, including social behaviors. Isolation housing may induce behavioral and neurochemical abnormalities in rats, although its influence on neurotransmitter lev...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.22036
更新日期:2020-09-18 00:00:00
abstract::Puberty marks the beginning of a period of dramatic physical, hormonal, and social change. This instability has made adolescence infamous as a time of "storm and stress" and it is well-established that stress during adolescence can be particularly damaging. However, prior stress may also shape the adolescent experienc...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21765
更新日期:2019-07-01 00:00:00
abstract::The neurological development of the kitten was studied from birth to 120 days of age. Three motor features present at birth disappeared within the 1st 45 days of life. The labyrinthine head and body righting reactions were present at birth; the latter matured only by 25 days of age when the air righting reaction (matu...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420120204
更新日期:1979-03-01 00:00:00
abstract::Despite evidence that acute stress impairs attention in adults, there has been minimal research in children. Here, the effects of acute stress on Go/No-go performance were examined in young children (M age = 5.41 years). Given the critical role of the parent-child relationship to children's self-regulatory development...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21915
更新日期:2020-05-01 00:00:00
abstract::Preweanling rats, 15 days of age, were placed in an unfamiliar cage containing 1 of a variety of surrogate conspecific stimuli. The surrogate stimuli consisted of a rat-sized aluminum tube covered with soft fluffy synthetic fur, a tanned rat pelt, felt, and an aluminum sheet. The surrogate was either maintained at amb...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420140206
更新日期:1981-03-01 00:00:00
abstract::The aim of the study was to investigate parental perception and interpretation of infant emotional expression depending on their attachment representation. Forty-six parents' responses to infant pictures depicting positive, neutral, and negative emotions were assessed on the level of affective judgments (valence, arou...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20441
更新日期:2010-07-01 00:00:00
abstract::In order to establish odors which can be used in appetitive and aversive conditioning paradigms, naive rat pups, postnatal day 7 (i.e., PND 7) and weanlings (PND 25), were placed in a rectangular open field with an odorant at one or both ends. Time spent over each odor was measured for 3 min. At both ages subjects avo...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/(sici)1098-2302(199809)33:2<157::aid-dev6>
更新日期:1998-09-01 00:00:00
abstract::Rat pups are more resistant to retroactive associative interference 3 hr after birth than 24 hr later [Cheslock et al. [2004] Developmental Science, 7, 581-598]. The present experiments tested the effect of age, retention interval and dam presence during the retention interval on odor-induced motor activity subsequent...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20456
更新日期:2010-05-01 00:00:00
abstract::The effects of an enriched environment (EE, permanent presence of a humanlike model plus colored mobile objects) during the rearing period (from birth to weaning at 3 months) were assessed on subsequent fear reactions of lambs and their mothers. Behavioral tests involved isolation, surprise effect, and the presence of...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/(sici)1098-2302(199807)33:1<33::aid-dev4>3
更新日期:1998-07-01 00:00:00
abstract::Motor overflow is extraneous movement in a limb not involved in a motor action. Typically, overflow is observed in people with neurological impairments and in healthy children and adults during strenuous and attention-demanding tasks. In the current study, we found that young infants produce vast amounts of motor over...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20595
更新日期:2012-05-01 00:00:00
abstract::Mammalian infant behavior directed toward caregivers is critical to survival and may play a role in establishing social bonds. Most mammalian infants vocalize when isolated. Rat pups vocalize at a higher rate when isolated following an interaction with an adult female than after an interaction with littermates, a phen...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20355
更新日期:2009-03-01 00:00:00
abstract::Artificial rearing (AR) of infant rats permits precise control over key features of the early environment without maternal influence. The present study examined the behavioral response of AR rats towards natural and drug-mediated rewards, as well as their exploratory and affective behaviors. Adolescent AR rats showed ...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.20139
更新日期:2006-05-01 00:00:00
abstract::Data from a variety of sources, including a number of tasks and dependent measures, suggests that a systematic inverse relationship exists between age and the amount of variability observed on simple measures of learning. Implications for general theoretical perspectives concerning ontogenetic differences in stimulus ...
journal_title:Developmental psychobiology
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1098-2302(199604)29:3<219::AID-DEV3>
更新日期:1996-04-01 00:00:00
abstract::Developmental aspects of behavioral organization were investigated in 29 healthy fetuses from 24-weeks gestation onwards: (a) short-term association between body (GM) and eye (EM) movements; (b) linkage of pairs of the three state variables [fetal heart rate pattern (FHRP), GM, and EM]; and (c) sequence of change of s...
journal_title:Developmental psychobiology
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1098-2302(199905)34:2<257::aid-dev2>
更新日期:1999-05-01 00:00:00
abstract::Effects of the presence or absence of the dam during testing and the retention interval on pretone heart rate (HR) and habituation and retention of an HR orienting response to tone were examined in prenatally cocaine-exposed and nontreated Sprague Dawley rat pups in two experiments. On postnatal day 16, each pup recei...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.10084
更新日期:2003-03-01 00:00:00
abstract::The effects of neonatal undernutrition in rats on food and water regulation, external indices of development, and long-term regulatory behavior were investigated. Undernutrition produced retardation in some external indices of development. The ability to eat, drink, and maintain body weight at weaning were not serious...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420110205
更新日期:1978-03-01 00:00:00
abstract::This study examined the development of ability to recognize familiar face in drawings in infants aged 6-8 months. In Experiment 1, we investigated infants' recognition of their mothers' faces by testing their visual preference for their mother's face over a stranger's face under three conditions: photographs, cartoons...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.21972
更新日期:2020-12-01 00:00:00
abstract::Patterns of visual interaction in mother-infant dyadic behavior have been reported for human and nonhuman primates, including age and gender differences among rhesus macaques. Such findings are tested with data from two developmental periods (Weeks 1-8 and 21-36) on Japanese macaque mother-infant visual behavior. Rate...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420170406
更新日期:1984-07-01 00:00:00
abstract::Investigations of maternal behavior of mothers fed a low-protein diet indicated deficits in retrieval and in the rate of nest-building. In addition, they indicated a concomitant increase in time spent with young when assessed during periods not associated with the retrieval/nest-building test session. The adrenalectom...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420100308
更新日期:1977-05-01 00:00:00
abstract::A wide variety of hypotheses have been put forth that address the functional significance of active sleep. Despite the well-accepted fact that active sleep expresses itself predominantly in the perinatal period, the vast majority of these functional hypotheses are applicable largely, if not exclusively, to the adult. ...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/(SICI)1098-2302(199601)29:1<1::AID-DEV1>3.
更新日期:1996-01-01 00:00:00
abstract::For the portion of their ontogeny, the juveniles of many mammalian species appear resistant to aggressive attack by adult male conspecifics. The possibility that urinary odors and small size contribute to this immunity from attack was investigated with C57/Bl, A/J, and DW/J laboratory mice. The results of the 1st of 6...
journal_title:Developmental psychobiology
pub_type: 杂志文章
doi:10.1002/dev.420150209
更新日期:1982-03-01 00:00:00