Tumour hypoxia affects the responsiveness of cancer cells to chemotherapy and promotes cancer progression.

abstract：:High grade gliomas (HGGs) are primary CNS cancers with more than 95% of patients experiencing tumor recurrence following radiation therapy, chemotherapy, and/or an anti-angiogenic therapy. Populations of glioma 'stem-like' cells (GSCs) exist in both proliferative and non-proliferative states and are capable of tumor r...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Gorin FA,Pasupuleti N,Mahajan D,Dugar S

更新日期：2017-01-01 00:00:00

abstract：:β-Glucans are polysaccharides of β-D-glucose extracted from the cell walls of different species of mushrooms, yeast, oat, barley, seaweeds, algae and bacteria. Modern biomedical research has identified β-glucans as biological response modifiers (BRM) with anti-tumor properties that elicit potent immune responses throu...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Albeituni SH,Yan J

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Angiogenesis is physiological process in embryogenesis, organ development, endometrial vasculature in menstrual cycle and wound healing. Angiogenesis has also been associated with several pathological conditions such as cancer, arthritis, atherosclerosis, etc. Out of the many growth factor responsible for an...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Bhanushali U,Kalekar-Joshi S,Kulkarni-Munshi R,Yellanki S,Medishetty R,Kulkarni P,Chelakara RS

更新日期：2017-01-01 00:00:00

abstract：:The importance of monoclonal antibodies in oncology has increased drastically following the discovery of Milstein and Kohler. Since the first approval of the monoclonal antibody, i.e. Rituximab in 1997 by the FDA, there was a decline in further applications but this number has significantly increased over the last thr...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Kaur N,Goyal A,Sindhu RK

更新日期：2020-01-01 00:00:00

abstract：:Sphingolipids are membrane lipids that play important roles in the regulation of cell functions and homeostasis. Alterations in their metabolism have been associated with several pathologies. For this reason, therapeutic strategies based on the design of small molecules to restore sphingolipid levels to their physiolo...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Delgado A,Fabrias G,Bedia C,Casas J,Abad JL

更新日期：2012-05-01 00:00:00

abstract：:We developed a drug-delivery system comprising a novel platinum drug (Pt(II) complex) entrapped within β-Casein (β-CN) nanoparticles referred to as nano-vehicles. Fluorescence spectroscopy, UV-Vis spectrometry, dynamic light scattering (DLS), and scanning electron microscopy (SEM) were used to characterize the β-CN-Pt...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Divsalar A,Razmi M,Saboury AA,Seyedarabi A

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Cancer is the second leading cause of death globally. Hydrazone and hydrazone derivatives have high activity, and for this reason, these compound are greatly used by researchers to synthesize new anti-cancer drug. The aim of this research work is to synthesize novel anticancer agents. METHODS:New hydrazone ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ünver H,Berber B,Demirel R,Koparal AT

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Coumarins are naturally occurring plant metabolites and several synthetic coumarin analogues are known for their various pharmacological properties such as anticoagulant, antimicrobial, anticancer, antioxidant, anti-inflammatory and antiviral properties. Objective; Keeping this promising pharmacological prop...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Kasumbwe K,Venugopala KN,Mohanlall V,Odhav B

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The ratio of live cells to total cells in a sample is a definition for cell viability or cell toxicity. The assessment of the viable cells plays a critical role in all processes of the cell culture workflows. Overall, they are used to evaluate the survival of cells and also to optimize culture ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Nozhat Z,Khalaji MS,Hedayati M,Kia SK

更新日期：2020-12-30 00:00:00

abstract：AIMS:Gallic acid (GA) is generally distributed in a variety of plants and foods, and possesses cell growth-inhibiting activities in cancer cell lines. In the present study, the impact of GA on cell viability, apoptosis induction and possible molecular mechanisms in cultured A549 lung carcinoma cells was investigated. ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Maimaiti A,Aili A,Kuerban H,Li X

更新日期：2018-01-01 00:00:00

abstract：:Histone deacetylase inhibitors (HDACIs) represent one of the most promising, recently developed classes of anticancer agents already approved by the U.S. FDA. The effectiveness of these new drugs has currently being explored in a variety of cancer cell lines, in vitro, animal models, in vivo, as well as in clinical tr...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Katafygiotis P,Giaginis C,Patsouris E,Theocharis S

更新日期：2013-03-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a cancer with extremely poor prognosis. This review discusses the pathological characteristics of multi-step hepatocarcinogenesis, tumor growth, invasion and metastasis, the expression of matrix metalloproteinases (MMPs) and their inhibitors via signal transduction in relation to dedi...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Okazaki I,Inagaki Y

更新日期：2012-09-01 00:00:00

abstract：:A majority of breast cancers (BC) display characteristics of epithelial cells and express estrogen receptors and/or HER-2 (a member of the epidermal growth factor receptor family). About one-fifth of BC is constituted of basal cells for which there is no specific category of proliferation regulators. Insulin-like grow...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Mester J,Redeuilh G

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:Elderly patients with metastatic colorectal cancer (mCRC) differ from the general population and are underrepresented in clinical trials. We, retrospectively, analyzed the safety and efficacy of XELOX regimen in the treatment of elderly patients affected by mCRC. PATIENTS AND METHODS:One-hundred-eleven consecu...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Berretta M,Aprile G,Nasti G,Urbani M,Bearz A,Lutrino S,Foltran L,Ferrari L,Talamini R,Fiorica F,Lleshi A,Canzonieri V,Lestuzzi C,Borsatti E,Fisichella R,Tirelli U

更新日期：2013-11-01 00:00:00

abstract：:In attempts to overcome the drawbacks of cisplatin - severe toxicity, drug resistance and poor oral bioavailability - the development of platinum-based drugs has progressed from carboplatin and oxaliplatin to the newest generation of drugs, such as satraplatin, picoplatin and the multinuclear platinum complex BBR3464 ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Olszewski U,Hamilton G

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVE:Multiparametric Magnetic Resonance Imaging (mpMRI) has become a very useful tool in the management of PCa. Particularly, there is a great interest in using mpMRI for men on Active Surveillance (AS) for low risk PCa. The aim of this systematic review was to critically review the latest literature concerning th...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Cantiello F,Manno S,Russo GI,Cimino S,Privitera S,Morgia G,Cicione A,Damiano R

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Glutathione (GSH), which is the predominant low molecular weight intracellular thiol in mammals, has multiple functions, such as those of protecting against oxidative stress and detoxifying endogenous and exogenous electrophiles. High GSH levels, which have been observed in various types of tumors, have been...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Cilurzo F,Cristiano MC,Da Pian M,Cianflone E,Quintieri L,Paolino D,Pasut G

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Sonchus oleraceus is a large and widespread plant in the world. It is edible to humans as a leaf vegetable and is also used as a folklore medicinal herb in the treatment of infections and inflammatory disease, but limited research on its chemical constituents has been done. OBJECTIVE:To isolate and identify...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Zhang H,Wang Y,Wang S,Wang Q,Wang T,Zhu J,Liu B

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Peniciketal A (Pe-A), a spiroketal compound, shows potent anticancer activities in human acute monocytic leukemia. However, the detailed mechanisms and potent targets of Pe-A remain largely unexplored. Here, we investigated the differentially expressed proteins between the Pe-A-treated group and the control ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Gao X,Zhou Y,Sun H,Liu D,Zhang J,Zhang J,Liu W,Pan X

更新日期：2019-01-01 00:00:00

abstract：:Various preclinical, clinical and epidemiological studies have already well established the cancer chemopreventive and chemoprotective potential of selenium compounds. In addition to its protective efficacy, recent studies have also proved the abilities of selenium compounds to induce cell death specifically in malign...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Chakraborty P,Roy SS,Bhattacharya S

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) is the main bioactive component of Brazilian green propolis, and possesses, among other things, anticancer properties. However, to the best of our knowledge, there are no studies of artepillin C in cervical cancer. METHOD:To explore a new therapeutic candid...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Souza RP,Bonfim-Mendonça PS,Damke GMZF,de-Assis Carvalho ARB,Ratti BA,Dembogurski DSO,da-Silva VRS,Silva SO,Da-Silva DB,Bruschi ML,Maria-Engler SS,Consolaro MEL

更新日期：2018-01-01 00:00:00

abstract：:In human pathologies, therapeutic treatments are often limited by the lack of selectivity of drugs and their elevated effective concentrations. Targeting these agents to a defined tissue could enhance their selectivity and then diminish their side effects when compared to drugs that accumulate in the entire body. Targ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Schmitt F,Juillerat-Jeanneret L

更新日期：2012-06-01 00:00:00

abstract：:Ras association domain family member 5 (RASSF5, also named NORE1) is an identified member of the RASSF gene family which could bind selectively to activate Ras and function as an antineoplastic effector in multiple cellular regulations. While highly expressed in majority of normal tissues, RASSF5 is epigenetically ina...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Li S,Teng J,Li H,Chen F,Zheng J

更新日期：2018-01-01 00:00:00

abstract：:Recently, intensive laboratory and preclinical studies have identified and validated therapeutic molecular targets in cancer, particularly the receptor tyrosine kinases, the intracellular pathways, and the genetic and epigenetic alterations, resulting in an unprecedented surge of novel, targeted therapies and therapeu...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Yasui H,Imai K

更新日期：2008-06-01 00:00:00

abstract：:For thousands of years medicine and natural products have been closely linked through the use of traditional medicines and natural poisons. Mushrooms have an established history of use in traditional oriental medicine, where most medicinal mushroom preparations are regarded as a tonic, that is, they have beneficial he...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ferreira IC,Vaz JA,Vasconcelos MH,Martins A

更新日期：2010-06-01 00:00:00

abstract：:The androgen receptor (AR) plays a crucial role in the physiological and pathological functions of androgen. As a transcription factor, the AR modulates androgen activity by regulating the transcription of target genes that are involved in numerous physiological functions and pathological disorders, such as acne vulga...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Shi Q,Shih CC,Lee KH

更新日期：2009-10-01 00:00:00

abstract：:A concept that currently steers the development of cancer therapies has been that agents directed against specific proteins that facilitate tumorigenesis or maintain a malignant phenotype will have greater efficacy, less toxicity and a more sustained response relative to traditional cytotoxic chemotherapeutic agents. ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Driscoll JJ,Minter A,Driscoll DA,Burris JK

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Using imatinib, a tyrosine kinase inhibitor drug used in lymphoblastic leukemia, has always had limitations due to its cardiotoxicity and hepatotoxicity side effects. The objective of this study is to develop a target-oriented drug carrier to minimize these adverse effects by the controlled release of the dr...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Varshosaz J,Fardshouraki S,Mirian M,Safaeian L,Jandaghian S,Taymouri S

更新日期：2020-01-01 00:00:00

abstract：:This review summarizes the reported molecular mechanisms underlying the antileukemic property of Sesquiterpene Lactones (SLs). This systematic review was registered in the PROSPERO database and conducted following the PRISMA Statements. The MeSH terms, Sesquiterpenes, Lactones and Leukemia were used in four databases ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： da Silva Castro E,Alves Antunes LA,Revoredo Lobo JF,Ratcliffe NA,Borges RM,Rocha L,Burth P,Fonte Amorim LM

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Reserpine, an indole alkaloid commonly used for hypertension, is found in the roots of Rauwolfia serpentina. Although the root extract has been used for the treatment of cancer, the molecular mechanism of its anti-cancer activity on hormonal independent prostate cancer remains elusive. METHODS:we evaluated ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ramamoorthy MD,Kumar A,Ayyavu M,Dhiraviam KN

更新日期：2018-01-01 00:00:00