VDAC1 Mediated Anticancer Activity of Gallic Acid in Human Lung Adenocarcinoma A549 Cells.

abstract：BACKGROUND:While Thioredoxin Reductase (TrxR) plays an important role in regulation of the intracellular redox balance and various signalling pathways, Glutathione S-Transferase (GSTs) enzymes belong to the detoxification family that catalyse the conjugation of glutathione with various endogenous and xenobiotic electro...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ozgencli I,Kilic D,Guller U,Ciftci M,Kufrevioglu OI,Budak H

更新日期：2018-01-01 00:00:00

abstract：:Effective elicitation of endogenous immunity is associated with improved prognosis for cancer patients. Clinical evidence in hematological and solid cancers shows that intratumoral injection of immunostimulatory genes primes and augments endogenous T cell responses. The ability of pro-inflammatory chemokines/cytokines...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Phan-Lai V,Kievit FM,Florczyk SJ,Wang K,Disis ML,Zhang M

更新日期：2014-02-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is the most frequent type of hematological cancer in the Western World. An accumulation of leukemic cells in peripheral blood of patients is a result of apoptosis disturbances as well as an increase in germinal centers CLL cell proliferation. The differences between CLL patients in t...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Kiliańska ZM,Rogalińska M

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Bendamustine, an N-mustard-benzoimidazole hybrid conjugate, was recently approved for the treatment of chronic lymphocytic leukemia. However, the short half-life of bendamustine may limit its clinical applications. OBJECTIVE:The purpose of this study is to design and synthesize compounds with a more favorab...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Detroja D,Chen TL,Lin YW,Yen TY,Wu MH,Tsai TH,Mehariya K,Kakadiya R,Lee TC,Shah A,Su TL

更新日期：2017-01-01 00:00:00

abstract：:Despite being long lived, anthracyclines remain the "evergreen" drugs in clinical practice of oncology, showing a potent effect in inhibiting cell growth in many types of tumors, including brain neoplasms. Unfortunately, they suffer from a poor penetration into the brain when intravenously administered due to multidru...

journal_title：Anti-cancer agents in medicinal chemistry

authors： da Ros M,Iorio AL,Lucchesi M,Stival A,de Martino M,Sardi I

更新日期：2015-01-01 00:00:00

abstract：:The systematic improvement of methods used for unraveling physiological and pathological role of proteases, as well as for elucidation of relevant hydrolase structures contributes to the progress in the area of new inhibitor-like drugs development. Many of protease inhibitors have entered clinics and are now successfu...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Białas A,Kafarski P

更新日期：2009-09-01 00:00:00

abstract：:Because invasion is, either directly or via metastasis formation, the main cause of death in cancer patients, development of efficient anti-invasive agents is an important research challenge. We have established a screening program for potentially anti-invasive compounds. The assay is based on organotypic confronting ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Bracke ME,Vanhoecke BW,Derycke L,Bolca S,Possemiers S,Heyerick A,Stevens CV,De Keukeleire D,Depypere HT,Verstraete W,Williams CA,McKenna ST,Tomar S,Sharma D,Prasad AK,DePass AL,Parmar VS

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:The cause of cervical cancer can be traced to Human Papilloma Virus (HPV) along with other, nonviral factors. The uterine cervix is reactive to hormones, and female hormones have been implicated in cervical cancer pathogenesis. Previous studies have indicated that malignant cervical cells tend to lose Estrog...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Yu P,Wang Y,Li C,Lv L,Wang J

更新日期：2018-01-01 00:00:00

abstract：:3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid is a secondary metabolite biosynthetically related to ferulic acid in which a geranyl chain is attached to the phenolic group, extracted from Acronychia baueri Schott (Fam. Rutaceae). In the last five years some of the pharmacological properties of 3-(4'-gerany...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Curini M,Epifano F,Genovese S,Marcotullio MC,Menghini L

更新日期：2006-11-01 00:00:00

abstract：:Breast cancer is the most common cancer among women, and ranks second among cancer deaths in women. Approximately 60% of all breast cancer patients have hormone-dependent breast cancer, which contains estrogen receptors and requires estrogen for tumor growth. Estradiol is biosynthesized from androgens by the cytochrom...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Díaz-Cruz ES,Brueggemeier RW

更新日期：2006-05-01 00:00:00

abstract：:Epigenetic modifications can affect numerous mechanisms used by neoplastic cells to evade immune control. In melanoma epigenetic defects, caused by dysregulations in the expression of genome writers, erasers, or readers, play a significant role in the reduced expression of molecules required for efficient immune recog...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Venza M,Visalli M,Catalano T,Beninati C,Teti D,Venza I

更新日期：2017-01-01 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) is a central controller of cell growth, proliferation, metabolism and angiogenesis. mTOR signaling is often dysregulated in various human diseases and thus attracts great interest in developing drugs that target mTOR. Currently it is known that mTOR functions as two complexes, mTOR...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Zhou H,Luo Y,Huang S

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Colorectal cancer is among the leading causes of death worldwide. The incidence of deaths is expected to be 11.4 million in 2030. OBJECTIVE:We aimed to evaluate the in vitro and in vivo antioxidant and antitumor activities of a novel Bithiophene- Fluorobenzamidine (BFB) against DMH-induced colorectal cancer...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Abdel-Rasol M,El-Beih NM,Yahya SMM,Ismail MA,El-Sayed WM

更新日期：2020-01-01 00:00:00

abstract：:The therapeutic potential of targeting p21-Activated Kinases (PAK1 - 6) for the treatment of cancer has recently gained traction in the biotech industry. Many pharmaceutically-viable ATP competitive inhibitors have been through different stages of pre-clinical development with only a single compound evaluated in human...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Senapedis W,Crochiere M,Baloglu E,Landesman Y

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The ratio of live cells to total cells in a sample is a definition for cell viability or cell toxicity. The assessment of the viable cells plays a critical role in all processes of the cell culture workflows. Overall, they are used to evaluate the survival of cells and also to optimize culture ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Nozhat Z,Khalaji MS,Hedayati M,Kia SK

更新日期：2020-12-30 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The DNA repair enzyme tyrosyl-DNA-phosphodiesterase 1 (TDP1) is a current inhibition target to improve the efficacy of cancer chemotherapy. Previous studies showed that compounds combining adamantane and monoterpenoid fragments are active against TDP1 enzyme. This investigation is focused on th...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Mozhaitsev ES,Zakharenko AL,Suslov EV,Korchagina DV,Zakharova OD,Vasil'eva IA,Chepanova AA,Black E,Patel J,Chand R,Reynisson J,Leung IKH,Volcho KP,Salakhutdinov NF,Lavrik OI

更新日期：2019-01-01 00:00:00

abstract：:A large group of aminoalkyl and aminoalkanol derivatives of selected dicarboximides were synthesized and characterized by 1HNMR, 13CNMR and ESI MS spectra analysis. The thirty nine new compounds were tested for their cytotoxic properties in human chronic (K562), acute leukemia (HL-60), and cervical cancer cells (HeLa)...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Kuran B,Napiórkowska M,Kossakowski J,Cieślak M,Kaźmierczak-Barańska J,Królewska K,Nawrot B

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Lung cancer is one of the most prevalent malignancies and thus the development of novel therapeutic agents for managing lung cancer is imperative. Tetrandrine, a bis-benzyltetrahydroisoquinoline alkaloid isolated from Stephania tetrandra S. Moore, has been found to exert cytotoxic effects on cancerous cells....

journal_title：Anti-cancer agents in medicinal chemistry

authors： Niu N,Qu T,Xu J,Lu X,Bodwell GJ,Zhao Z

更新日期：2019-01-01 00:00:00

abstract：:Apoptosis, or programmed cell death, is an important physiologic process multicellular organisms use to maintain homeostasis by providing a means for elimination of redundant cells during development. Furthermore, cells that have become damaged or are defective undergo apoptosis to prevent disease. It is an important ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Zeng W,Miao W

更新日期：2009-11-01 00:00:00

abstract：:The success of anticancer therapy is limited due to the resistance caused by tumor cells to cytotoxic agents, which interfere with the effectiveness of various chemotherapeutic agents. Several mechanisms for decreased effectiveness of anti-cancer drugs have been examined however the most widely studied mechanism is th...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Kumar R,Kaur M,Silakari O

更新日期：2014-06-01 00:00:00

abstract：:Natural and synthetic carbazoles, either in a pure substituted or in an annellated substituted form, represent an important and heterogeneous class of anticancer agents, which has grown considerably over the last two decades. Many carbazole derivatives have been tested for cyctotoxic activity, some of them have entere...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Asche C,Demeunynck M

更新日期：2007-03-01 00:00:00

abstract：:Cancer is the deadliest disease worldwide and the development of safer chemical entities to treat cancer is one of the major challenges of medicinal chemistry. Emergence of new cases every year and development of multiple drug resistance against available molecular entities has turned the focus of researchers towards ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Shukla S,Sood AK,Goyal K,Singh A,Sharma V,Guliya N,Gulati S,Kumar S

更新日期：2020-11-24 00:00:00

abstract：:Sphingosine 1-phosphate (S1P) is a bioactive lipid with diverse biological functions, including cell proliferation, differentiation, angiogenesis, chemotaxis, and migration. Many of the activities of S1P are mediated through five closely related G-protein-coupled receptors of the sphingosine-1-phosphate receptor famil...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Watters RJ,Wang HG,Sung SS,Loughran TP,Liu X

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Multi-kinase inhibitor sorafenib showed dramatic effects in acute myeloid leukemia (AML) cells harboring fms-related tyrosine kinase 3-internal tandem duplication (FLT3-ITD) mutation. However, FLT3-ITD mutation only occurs in 25% of AML cases. The therapeutic effects of sorafenib in AML patients without FLT3...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Yang N,Gu Z,Liu Z,Huang W,Wang S,Wang L,Gao C

更新日期：2018-01-01 00:00:00

abstract：:The risk of developing colorectal cancer increases in patients with inflammatory bowel disease (IBD) and a growing body of evidence shows the critical role of interleukin (IL-6) in this process. IL-6 is both a pro- and anti-inflammatory cytokine whose effects are mediated through activation of STAT3. Recent studies ha...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Moriasi C,Subramaniam D,Awasthi S,Ramalingam S,Anant S

更新日期：2012-12-01 00:00:00

abstract：:A concept that currently steers the development of cancer therapies has been that agents directed against specific proteins that facilitate tumorigenesis or maintain a malignant phenotype will have greater efficacy, less toxicity and a more sustained response relative to traditional cytotoxic chemotherapeutic agents. ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Driscoll JJ,Minter A,Driscoll DA,Burris JK

更新日期：2011-02-01 00:00:00

abstract：:The kinesin spindle protein (KSP, also known as Hs Eg5) plays an essential part in the proper separation of spindle poles and the correct formation of bipolar mitotic spindle during mitosis. Inhibition of this protein results in cells apoptosis followed by mitotic arrest and the formation of characteristic monoaster s...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Zhang Y,Xu W

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Araucaria angustifolia extract (AAE) is a polyphenol-rich extract that has gained interest as a natural anticancer agent. Recent work suggests that AAE induces oxidative damage and apoptosis through its action on decreasing complex I activity of the mitochondrial Electron Transport Chain (ETC). AIMS AND MET...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Branco CS,Duong A,Machado AK,Scola G,Andreazza AC,Salvador M

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Colorectal Cancer (CRC) is one of the most common fatal diseases with high morbidity. Alteration of glucose metabolism is one of the hallmarks in the development of CRC. Glucose Transporter 1 (GLUT1) is a key rate-limiting protein in hyperactive glucose metabolism and up-regulated in CRC, however, the underl...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Kuai XY,Lei ZY,Liu XS,Shao XY

更新日期：2020-01-01 00:00:00

abstract：:For thousands of years medicine and natural products have been closely linked through the use of traditional medicines and natural poisons. Mushrooms have an established history of use in traditional oriental medicine, where most medicinal mushroom preparations are regarded as a tonic, that is, they have beneficial he...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ferreira IC,Vaz JA,Vasconcelos MH,Martins A

更新日期：2010-06-01 00:00:00