Novel Inhibitors of DNA Repair Enzyme TDP1 Combining Monoterpenoid and Adamantane Fragments.

abstract：BACKGROUND:Curcumin is a natural polyphenol and lead compound of the rhizomes of curcuma longa that it has been widely used for pharmacological activities. OBJECTIVE:In this study, series of novel derivatives of curcumin, which this group was linked to a 2-amino-4-phenylpyran-3-carbonitrile system, have been synthesiz...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Arjomandi OK,Almasi S,Hosseinzadeh L,Kavoosi M,Adibi H

更新日期：2020-10-02 00:00:00

abstract：BACKGROUND:Glutathione (GSH), which is the predominant low molecular weight intracellular thiol in mammals, has multiple functions, such as those of protecting against oxidative stress and detoxifying endogenous and exogenous electrophiles. High GSH levels, which have been observed in various types of tumors, have been...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Cilurzo F,Cristiano MC,Da Pian M,Cianflone E,Quintieri L,Paolino D,Pasut G

更新日期：2019-01-01 00:00:00

abstract：:In the early 1960s, inorganic pyrophosphate (PPi) was found to be present in body fluids and to act as a natural inhibitor of calcification by its interaction with hydroxyapatite. In addition to inhibiting the formation of calcium phosphate, PPi also inhibited dissolution of hydroxyapatite crystals, which made it inte...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Widler L,Jahnke W,Green JR

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Coumarins are naturally occurring plant metabolites and several synthetic coumarin analogues are known for their various pharmacological properties such as anticoagulant, antimicrobial, anticancer, antioxidant, anti-inflammatory and antiviral properties. Objective; Keeping this promising pharmacological prop...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Kasumbwe K,Venugopala KN,Mohanlall V,Odhav B

更新日期：2017-01-01 00:00:00

abstract：:Tea catechins exhibit a broad range of pharmacological activities that impart beneficial effects on human health. Epigallocatechin-3-gallate (EGCG), one of the major tea catechins, has been widely associated with cancer prevention and treatment. In addition, tea catechins in combination with anticancer drugs are being...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Shang W,Lu W,Han M,Qiao J

更新日期：2014-01-01 00:00:00

abstract：:Due to an oversight one of the author's name was published wrong in the article entitled "Design, Synthesis and Biological Evaluation of a Phenyl Butyric Acid Derivative, N-(4-chlorophenyl)-4- phenylbutanamide: A HDAC6 Inhibitor with Anti-proliferative Activity on Cervix Cancer and Leukemia Cells" in "Anti-Cancer Agen...

journal_title：Anti-cancer agents in medicinal chemistry

authors：

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND & OBJECTIVE:Nowadays, the interaction between natural products and microRNAs provides a promising field for exploring the chemo preventive agents for various cancers.As a member of microRNAs, the expression of let-7f-5p is universally down regulated in colorectal cancer (CRC). The present study aimed to unco...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Feng Y,Liu X,Han Y,Chen M,Zhang L,Hu Y,Chen L,Chen G,Li N

更新日期：2020-07-30 00:00:00

abstract：PURPOSE:Elderly patients with metastatic colorectal cancer (mCRC) differ from the general population and are underrepresented in clinical trials. We, retrospectively, analyzed the safety and efficacy of XELOX regimen in the treatment of elderly patients affected by mCRC. PATIENTS AND METHODS:One-hundred-eleven consecu...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Berretta M,Aprile G,Nasti G,Urbani M,Bearz A,Lutrino S,Foltran L,Ferrari L,Talamini R,Fiorica F,Lleshi A,Canzonieri V,Lestuzzi C,Borsatti E,Fisichella R,Tirelli U

更新日期：2013-11-01 00:00:00

abstract：:Evidence supports that a variety of cancers are sparked by the growth of cells that exhibit characteristics of stem cells. Such cancer-initiating cells are capable of populating a tumor with a heterogeneous group of daughter cells while still maintaining the ability to self-renew. Several groups have recently reported...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Murphy SK

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:In recent years, targeted cancer treatment methods at various molecular levels have been developed for Non-Small Cell Lung Cancer (NSCLC), one of two major subtypes of lung cancer. miRNAbased clinical trials are currently the preferred targeted therapeutic strategy. Also, ceRNAs (competing endogenous RNA) wo...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ergun S,Güney S,Temiz E,Petrovic N,Gunes S

更新日期：2018-01-01 00:00:00

abstract：:Integration of geriatric assessment into cancer clinical practice is strongly needed in squamous cell carcinoma of the head and neck (SCCHN) due to the frequent discrepancy between chronologic and biologic age. Comprehensive Geriatric Assessment (CGA) is a multidimensional assessment tool that examines age-related dom...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Perri F,Ionna F,Pavone E,Longo F,Caponigro F

更新日期：2013-11-01 00:00:00

abstract：INTRODUCTION:Esophageal cancer remains an aggressive disease with poor survival rates. FAK and IGF-1R are two important tyrosine kinases important for cell survival signaling and found to be upregulated in esophageal cancer. Our hypothesis is that a novel small molecule compound that disrupts FAK and IGF-1R protein-pro...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ucar DA,Cox A,He DH,Ostrov DA,Kurenova E,Hochwald SN

更新日期：2011-09-01 00:00:00

abstract：:Various preclinical, clinical and epidemiological studies have already well established the cancer chemopreventive and chemoprotective potential of selenium compounds. In addition to its protective efficacy, recent studies have also proved the abilities of selenium compounds to induce cell death specifically in malign...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Chakraborty P,Roy SS,Bhattacharya S

更新日期：2015-01-01 00:00:00

abstract：:High grade gliomas (HGGs) are primary CNS cancers with more than 95% of patients experiencing tumor recurrence following radiation therapy, chemotherapy, and/or an anti-angiogenic therapy. Populations of glioma 'stem-like' cells (GSCs) exist in both proliferative and non-proliferative states and are capable of tumor r...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Gorin FA,Pasupuleti N,Mahajan D,Dugar S

更新日期：2017-01-01 00:00:00

abstract：:We developed a drug-delivery system comprising a novel platinum drug (Pt(II) complex) entrapped within β-Casein (β-CN) nanoparticles referred to as nano-vehicles. Fluorescence spectroscopy, UV-Vis spectrometry, dynamic light scattering (DLS), and scanning electron microscopy (SEM) were used to characterize the β-CN-Pt...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Divsalar A,Razmi M,Saboury AA,Seyedarabi A

更新日期：2014-01-01 00:00:00

abstract：:Sphingolipids are major constituents of the cells with emerging roles in the regulation of cellular processes. Deregulation of sphingolipid metabolism is reflected as various pathophysiological conditions including metabolic disorders and several forms of cancer. Ceramides, ceramide-1-phosphate (C1P), glucosyl ceramid...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ekiz HA,Baran Y

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:The existence of drug-resistance and lack of selectivity encourages scientists to search for novel and more selective cytotoxic agents. OBJECTIVES:In this work, novel 1,3,4-triarylpyrazole derivatives were synthesized to study their cytotoxicity on MCF7 (human breast Cell Line). In addition, QSAR studies we...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ismail MMF,Farrag AM,Harras MF

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Gemin D (GD) is an ellagitannin found in several plant species rich in phenolic compounds. Its many beneficial properties include antioxidant and antitumoral. OBJECTIVE:The present study assessed the genotoxicity, cytotoxicity, antigenotoxicity, and anticytotoxicity of GD by in vitro and in vivo assays. ME...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Carneiro CC,de Moraes-Filho AV,Fernandes AS,da Costa Santos S,de Melo E Silva D,Chen LC

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Cancer is the second leading cause of death globally. Hydrazone and hydrazone derivatives have high activity, and for this reason, these compound are greatly used by researchers to synthesize new anti-cancer drug. The aim of this research work is to synthesize novel anticancer agents. METHODS:New hydrazone ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ünver H,Berber B,Demirel R,Koparal AT

更新日期：2019-01-01 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) is a central controller of cell growth, proliferation, metabolism and angiogenesis. mTOR signaling is often dysregulated in various human diseases and thus attracts great interest in developing drugs that target mTOR. Currently it is known that mTOR functions as two complexes, mTOR...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Zhou H,Luo Y,Huang S

更新日期：2010-09-01 00:00:00

abstract：:β-Glucans are polysaccharides of β-D-glucose extracted from the cell walls of different species of mushrooms, yeast, oat, barley, seaweeds, algae and bacteria. Modern biomedical research has identified β-glucans as biological response modifiers (BRM) with anti-tumor properties that elicit potent immune responses throu...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Albeituni SH,Yan J

更新日期：2013-06-01 00:00:00

abstract：AIM:The aim of our research work is the synthesis of tetrahydroisoquinoline derivatives as anti-Angiogenesis and anti-cancer agents. BACKGROUND:Cancer is the second leading cause of deaths in United States. The current recovery rate from the advanced treatment for the cancer is unacceptably low. Therefore, identificat...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Gangapuram M,Eyunni S,Zhang W,Redda KK

更新日期：2021-01-12 00:00:00

abstract：:Reactive oxygen species (ROS) are produced as normal products of cellular metabolism, which are essential for numerous cell biological functions. Due to aberrant metabolism, oncogenic signaling activation and mitochondrial dysfunction, cancer cells generate excessive ROS that cause severe oxidative damage, finally lea...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Cheng Y,Qi Y

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Glucosamine is a widely prescribed dietary supplement used in the treatment of osteoarthritis. In the present study, the chemoprotectant ability of glucosamine was evaluated against cisplatin-induced genotoxicity and cytotoxicity in rat bone marrow cells. METHODS:Glucosamine was orally adminis...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Cheki M,Jafari S,Najafi M,Mahmoudzadeh A

更新日期：2019-01-01 00:00:00

abstract：:The Src family of kinases has nine known members, all of which are nonreceptor tyrosine kinases involved in signal transduction in both normal and cancer cells. Interest in these kinases has increased recently because of the development, initial clinical success, and low toxicity of pharmacologic inhibitors. c-Src is ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Johnson FM,Gallick GE

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Pyrazole derivatives have been reported as both anticancer and antiinflammatory agents. OBJECTIVE:This study was conducted to develop new pyrazole derivatives as potential anticancer and/or antiinflammatory agents. Their molecular mechanisms of action have been investigated. METHOD:a series of new triarylp...

journal_title：Anti-cancer agents in medicinal chemistry

authors： El-Gamal MI,Abdel-Maksoud MS,Gamal El-Din MM,Shin JS,Lee KT,Yoo KH,Oh CH

更新日期：2017-01-01 00:00:00

abstract：:Colorectal cancer is a major global health problem with more than a million new cases diagnosed worldwide in 2005. In the United States, this malignancy is the third most common with 145,000 new cases and the second most lethal with 56,000 deaths in 2005. Unfortunately, preclinical diagnostic screening in the U.S. pop...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Majer M,Akerley W,Kuwada SK

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:T-LAK cell-originated protein kinase (TOPK) belongs to the serine/threonine protein kinase family. It is highly expressed in RPMI7951 melanoma cells. Scutellarin (SCU) is an active ingredient extracted from Erigeron breviscapus (Vant.) Hand.-Mazz. Its main physiological functions are related to its anti-infl...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Mu X,Wang L,Zhang Z,Ge R,Zhang J,Mou K,Liu W,Lv S

更新日期：2020-08-10 00:00:00

abstract：BACKGROUND:Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) is the main bioactive component of Brazilian green propolis, and possesses, among other things, anticancer properties. However, to the best of our knowledge, there are no studies of artepillin C in cervical cancer. METHOD:To explore a new therapeutic candid...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Souza RP,Bonfim-Mendonça PS,Damke GMZF,de-Assis Carvalho ARB,Ratti BA,Dembogurski DSO,da-Silva VRS,Silva SO,Da-Silva DB,Bruschi ML,Maria-Engler SS,Consolaro MEL

更新日期：2018-01-01 00:00:00

abstract：:The kinesin spindle protein (KSP, also known as Hs Eg5) plays an essential part in the proper separation of spindle poles and the correct formation of bipolar mitotic spindle during mitosis. Inhibition of this protein results in cells apoptosis followed by mitotic arrest and the formation of characteristic monoaster s...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Zhang Y,Xu W

更新日期：2008-08-01 00:00:00