Rotundic Acid Regulates the Effects of Let-7f-5p on Caco2 Cell Proliferation.

abstract：BACKGROUND:In recent years, targeted cancer treatment methods at various molecular levels have been developed for Non-Small Cell Lung Cancer (NSCLC), one of two major subtypes of lung cancer. miRNAbased clinical trials are currently the preferred targeted therapeutic strategy. Also, ceRNAs (competing endogenous RNA) wo...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ergun S,Güney S,Temiz E,Petrovic N,Gunes S

更新日期：2018-01-01 00:00:00

abstract：METHODS:A novel series of isoxazole (S21-S30) derivatives were designed, synthesized and screened for their anticancer activity against estrogen receptor-positive MCF-7 and negative MDA-MB-435 breast cancer cell lines. The synthesized derivative has the ability to inhibit the growth of the human breast cancer cell line...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Mokale SN,Sakle NS,Bhavale SA,Lokwani DK,Shelke VR

更新日期：2018-01-01 00:00:00

abstract：:Protein kinases are one of the largest known families of enzyme characterized by having a well conserved ATP binding pocket. Most of the synthetic kinase inhibitors are ATP-competitive, but display some potential problems, like selectivity, discrepancy between the in vitro and in vivo inhibition assays and an high ris...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Cozza G,Bortolato A,Menta E,Cavalletti E,Spinelli S,Moro S

更新日期：2009-09-01 00:00:00

abstract：:β-Glucans are polysaccharides of β-D-glucose extracted from the cell walls of different species of mushrooms, yeast, oat, barley, seaweeds, algae and bacteria. Modern biomedical research has identified β-glucans as biological response modifiers (BRM) with anti-tumor properties that elicit potent immune responses throu...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Albeituni SH,Yan J

更新日期：2013-06-01 00:00:00

abstract：:Glioblastoma Multiforme (GMB) is the most aggressive primary brain tumor with poor survival rates and universal recurrence despite aggressive treatments. Recent research suggested that GBM has multiple glioma cell populations, some of which are organized in a stem cell hierarchical order with different stages of diffe...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Alexandru-Abrams D,Jadus MR,Hsu FP,Stathopoulos A,Bota DA

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Obesity is characterized by increased long chain fatty acids (LCFA) uptake and impaired lipid metabolism in hepatocytes. Consequently, an enhanced intracellular lipid content, including sphingolipids, may lead to lipotoxicity. It is believed that resveratrol (RSV), one of the most extensively studied plant-d...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Charytoniuk T,Harasim-Symbor E,Polak A,Drygalski K,Berk K,Chabowski A,Konstantynowicz-Nowicka K

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:The development of cancer stem-like cells (CSCs) is one of the main causes of ovarian cancer tolerance to radiotherapy. Autophagy is an adaptive process by which cells repair damage due to radiation. As a metabolite of riboflavin, lumiflavin can enhance the chemotherapeutic effects of cisplatin on ovarian ca...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Wu M,Huang Y,Song Z,Yang R

更新日期：2021-01-04 00:00:00

abstract：BACKGROUND:Fruits of Morus alba L. (mulberry) have various bioactive compounds such as polyphenols and anthocyanins and used as a herbal medicine. However, the anti-cancer effects and molecular basis have not been elucidated. METHODS:We isolated the cyanidin-3-glucoside in various cultivar of mulberry by acidified-met...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Cho E,Chung EY,Jang HY,Hong OY,Chae HS,Jeong YJ,Kim SY,Kim BS,Yoo DJ,Kim JS,Park KH

更新日期：2017-11-24 00:00:00

abstract：:Life expectancy has impressively increased over the past century and the US population over 65 years is rapidly growing, especially those over 80 years. In fact, persons older than 80 years have increased by more than 250% between the years 1960 and 2000, and it is expected that the population aged >75 years will trip...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ciancia R,Tirelli U,Ribera J,Spina M

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Gemin D (GD) is an ellagitannin found in several plant species rich in phenolic compounds. Its many beneficial properties include antioxidant and antitumoral. OBJECTIVE:The present study assessed the genotoxicity, cytotoxicity, antigenotoxicity, and anticytotoxicity of GD by in vitro and in vivo assays. ME...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Carneiro CC,de Moraes-Filho AV,Fernandes AS,da Costa Santos S,de Melo E Silva D,Chen LC

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Pyrazolo[3,4-d]pyrimidine scaffold was reported to possess potent cytotoxic and CDK2 inhibitory activity as analogue of roscovitine. OBJECTIVE:To design and synthesize novel 1-(4-flourophenyl)pyrazolo[3,4-d]pyrimidine derivatives as bioisosters of roscovitine with potential cytotoxic and CDK2 inhibitory act...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Maher M,Kassab AE,Zaher AF,Mahmoud Z

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Sonchus oleraceus is a large and widespread plant in the world. It is edible to humans as a leaf vegetable and is also used as a folklore medicinal herb in the treatment of infections and inflammatory disease, but limited research on its chemical constituents has been done. OBJECTIVE:To isolate and identify...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Zhang H,Wang Y,Wang S,Wang Q,Wang T,Zhu J,Liu B

更新日期：2020-01-01 00:00:00

abstract：:The use of statins has scaled up to become one of the most prescribed medicines in the world and have been very useful in the manegement of cardiovascular diseases and related mortality. The disclosure of their chemical structure similar to that of hydroxy methyl glutaryl-CoA (HMG-CoA) revealed their ability to compet...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Garcia-Ruiz C,Morales A,Fernandez-Checa JC

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Peniciketal A (Pe-A), a spiroketal compound, shows potent anticancer activities in human acute monocytic leukemia. However, the detailed mechanisms and potent targets of Pe-A remain largely unexplored. Here, we investigated the differentially expressed proteins between the Pe-A-treated group and the control ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Gao X,Zhou Y,Sun H,Liu D,Zhang J,Zhang J,Liu W,Pan X

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Araucaria angustifolia extract (AAE) is a polyphenol-rich extract that has gained interest as a natural anticancer agent. Recent work suggests that AAE induces oxidative damage and apoptosis through its action on decreasing complex I activity of the mitochondrial Electron Transport Chain (ETC). AIMS AND MET...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Branco CS,Duong A,Machado AK,Scola G,Andreazza AC,Salvador M

更新日期：2019-01-01 00:00:00

abstract：:Radiolabelled peptides have shown to be an important class of radiopharmaceuticals for imaging and therapy of malignancies expressing receptors of regulatory peptides. These peptides have high affinity and specificity for their receptors. The majority of these receptors are present at different levels in different tis...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Breeman WA,Kwekkeboom DJ,de Blois E,de Jong M,Visser TJ,Krenning EP

更新日期：2007-05-01 00:00:00

abstract：:Of late medicinal plants and functional foods rich in bioactive phytochemicals have received growing attention as potential agents for cancer chemoprevention. Accumulating evidence from epidemiological studies as well as laboratory data supports the anticancer properties of garlic widely used as a medicinal herb and s...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Nagini S

更新日期：2008-04-01 00:00:00

abstract：:A physiologically stable thiolate gold(I) derivative [Au(Spyrimidine)(PTA-CH2Ph)]Br has shown inhibition in colon cancer proliferation of Caco-2/TC7, Caco-2/PD7 and HTC-116-luc2 cell lines via apoptotic pathway and S-phase arrest in the cell cycle. Intraperitoneal injection of [Au(Spyrimidine)(PTA-CH2Ph)]Br in athymic...

journal_title：Anti-cancer agents in medicinal chemistry

authors： García-Moreno E,Gascón S,García de Jalón JA,Romanos E,Rodriguez-Yoldi MJ,Cerrada E,Laguna M

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Multi-kinase inhibitor sorafenib showed dramatic effects in acute myeloid leukemia (AML) cells harboring fms-related tyrosine kinase 3-internal tandem duplication (FLT3-ITD) mutation. However, FLT3-ITD mutation only occurs in 25% of AML cases. The therapeutic effects of sorafenib in AML patients without FLT3...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Yang N,Gu Z,Liu Z,Huang W,Wang S,Wang L,Gao C

更新日期：2018-01-01 00:00:00

abstract：:Recently, intensive laboratory and preclinical studies have identified and validated therapeutic molecular targets in cancer, particularly the receptor tyrosine kinases, the intracellular pathways, and the genetic and epigenetic alterations, resulting in an unprecedented surge of novel, targeted therapies and therapeu...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Yasui H,Imai K

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:The network interactions link human disease proteins to regulatory cellular pathways leading to better understanding of protein functions and cellular processes. Revealing the network of signaling pathways in cancer through protein-protein interactions at molecular level enhances our understanding of Hepatoc...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ranjpour M,Katare DP,Wajid S,Jain SK

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Intrinsic resistance to apoptotic cell death due to co-occurrence of mutated KRAS and p53 is frequently reported in pancreatic cancer that renders them aggressive, highly proliferative and metastatic. In addition, these cancer types are less sensitive to apoptosis inducing drugs where promotion of autophagic...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Pal S,Salunke-Gawalib S,Konkimallaa VB

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The present study was carried out to evaluate the anticancer property of an alkylamino phenol derivative -2-((3,4-Dihydroquinolin-1(2H)-yl)(p-tolyl)methyl)phenol) (THTMP) against human breast cancer cells. The cytotoxicity of the THTMP was assessed to know its specificity towards breast cancer ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Palanivel S,Yli-Harja O,Kandhavelu M

更新日期：2020-01-01 00:00:00

abstract：:Sphingosine 1-phosphate (S1P) is a bioactive lipid with diverse biological functions, including cell proliferation, differentiation, angiogenesis, chemotaxis, and migration. Many of the activities of S1P are mediated through five closely related G-protein-coupled receptors of the sphingosine-1-phosphate receptor famil...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Watters RJ,Wang HG,Sung SS,Loughran TP,Liu X

更新日期：2011-11-01 00:00:00

abstract：:Due to an oversight one of the author's name was published wrong in the article entitled "Design, Synthesis and Biological Evaluation of a Phenyl Butyric Acid Derivative, N-(4-chlorophenyl)-4- phenylbutanamide: A HDAC6 Inhibitor with Anti-proliferative Activity on Cervix Cancer and Leukemia Cells" in "Anti-Cancer Agen...

journal_title：Anti-cancer agents in medicinal chemistry

authors：

更新日期：2018-01-01 00:00:00

abstract：:Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that resides at the sites of focal adhesions. The 125 kDa FAK protein is encoded by the FAK gene located on human chromosome 8q24. Structurally, FAK consists of an amino-terminal regulatory FERM domain, a central catalytic kinase domain, and a carboxy-termi...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Golubovskaya VM

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Liposomes have been employed to improve pharmacokinetics and reduce side effects of drugs. They can be functionalized with antibodies for targeted delivery. While the monoclonal antibody trastuzumab has been employed in the therapy of HER2-positive breast cancer, the resistance developed during treatment has...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Eloy JO,Petrilli R,Brueggemeier RW,Marchetti JM,Lee RJ

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Coumarins are naturally occurring plant metabolites and several synthetic coumarin analogues are known for their various pharmacological properties such as anticoagulant, antimicrobial, anticancer, antioxidant, anti-inflammatory and antiviral properties. Objective; Keeping this promising pharmacological prop...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Kasumbwe K,Venugopala KN,Mohanlall V,Odhav B

更新日期：2017-01-01 00:00:00

abstract：AIM:The aim of our research work is the synthesis of tetrahydroisoquinoline derivatives as anti-Angiogenesis and anti-cancer agents. BACKGROUND:Cancer is the second leading cause of deaths in United States. The current recovery rate from the advanced treatment for the cancer is unacceptably low. Therefore, identificat...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Gangapuram M,Eyunni S,Zhang W,Redda KK

更新日期：2021-01-12 00:00:00

abstract：BACKGROUND:Glutathione (GSH), which is the predominant low molecular weight intracellular thiol in mammals, has multiple functions, such as those of protecting against oxidative stress and detoxifying endogenous and exogenous electrophiles. High GSH levels, which have been observed in various types of tumors, have been...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Cilurzo F,Cristiano MC,Da Pian M,Cianflone E,Quintieri L,Paolino D,Pasut G

更新日期：2019-01-01 00:00:00