The interactions of anticancer agents with tea catechins: current evidence from preclinical studies.

Abstract:

:Tea catechins exhibit a broad range of pharmacological activities that impart beneficial effects on human health. Epigallocatechin-3-gallate (EGCG), one of the major tea catechins, has been widely associated with cancer prevention and treatment. In addition, tea catechins in combination with anticancer drugs are being evaluated as a new cancer treatment strategy. However, the interactions of anticancer drugs with tea catechins are largely unknown. Accumulated data indicate significant interactions between anticancer drugs and tea catechins, such as synergistic tumor inhibition or antagonist activity. Therefore, it is critical to understand comprehensively the effects of tea catechins on anticancer drugs. Focusing on evidence from preclinical studies, this paper will review the interactions between anticancer drugs and tea catechins, including pharmacodynamics and pharmacokinetics effects. We hope that by detailing the interactions between anticancer drugs and tea catechins, more attention will be directed to this important therapeutic combination in the future.

authors

Shang W,Lu W,Han M,Qiao J

doi

10.2174/1871520614666140829123651

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

1343-50

issue

10

eissn

1871-5206

issn

1875-5992

pii

ACAMC-EPUB-62074

journal_volume

14

pub_type

杂志文章,评审
  • Cytotoxic Sesquiterpenes from Sonchus oleraceus.

    abstract:BACKGROUND:Sonchus oleraceus is a large and widespread plant in the world. It is edible to humans as a leaf vegetable and is also used as a folklore medicinal herb in the treatment of infections and inflammatory disease, but limited research on its chemical constituents has been done. OBJECTIVE:To isolate and identify...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章

    doi:10.2174/1871520620666200101152934

    authors: Zhang H,Wang Y,Wang S,Wang Q,Wang T,Zhu J,Liu B

    更新日期:2020-01-01 00:00:00

  • Benzophenone Sulfonamide Derivatives as Interacting Partners and Inhibitors of Human P-glycoprotein.

    abstract:BACKGROUND:Human P-glycoprotein (P-gp) is a transmembrane protein that belongs to the ATPBinding Cassette (ABC) transporters family. Physiologically, it exports toxins out of the cell, however, its overexpression leads to the phenomena of Multidrug-Resistance (MDR) by exporting a diverse range of compounds, which are s...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章

    doi:10.2174/1871520620666200516144403

    authors: Farman S,Javed A,Arshia,Khan KM,Nasir A,Khan AU,Lodhi MA,Gul H,Khan F,Asad M,Parveen Z

    更新日期:2020-01-01 00:00:00

  • Acetogenins as Potential Anticancer Agents.

    abstract::Acetogenins (ACG) are naturally occurring compounds that are chemically one of the least investigated families. In the review, we have provided a comprehensive listing of 133 of these compounds for which anti-tumor activity has been documented within the literature. We have compiled and studied their chemical structur...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/1871520615666150629101827

    authors: Mangal M,Khan MI,Agarwal SM

    更新日期:2015-01-01 00:00:00

  • Molecular mechanism behind the synergistic activity of diphenylmethyl selenocyanate and Cisplatin against murine tumor model.

    abstract::Various preclinical, clinical and epidemiological studies have already well established the cancer chemopreventive and chemoprotective potential of selenium compounds. In addition to its protective efficacy, recent studies have also proved the abilities of selenium compounds to induce cell death specifically in malign...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章

    doi:10.2174/1871520615666150113123401

    authors: Chakraborty P,Roy SS,Bhattacharya S

    更新日期:2015-01-01 00:00:00

  • Novel 1,3,4-Triaryl Pyrazoles: Synthesis, QSAR Studies and Cytotoxicity against Breast Cancer.

    abstract:BACKGROUND:The existence of drug-resistance and lack of selectivity encourages scientists to search for novel and more selective cytotoxic agents. OBJECTIVES:In this work, novel 1,3,4-triarylpyrazole derivatives were synthesized to study their cytotoxicity on MCF7 (human breast Cell Line). In addition, QSAR studies we...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章

    doi:10.2174/1871520619666190207094610

    authors: Ismail MMF,Farrag AM,Harras MF

    更新日期:2019-01-01 00:00:00

  • Reserpine Induces Apoptosis and Cell Cycle Arrest in Hormone Independent Prostate Cancer Cells through Mitochondrial Membrane Potential Failure.

    abstract:BACKGROUND:Reserpine, an indole alkaloid commonly used for hypertension, is found in the roots of Rauwolfia serpentina. Although the root extract has been used for the treatment of cancer, the molecular mechanism of its anti-cancer activity on hormonal independent prostate cancer remains elusive. METHODS:we evaluated ...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章

    doi:10.2174/1871520618666180209152215

    authors: Ramamoorthy MD,Kumar A,Ayyavu M,Dhiraviam KN

    更新日期:2018-01-01 00:00:00

  • Induction of Apoptosis by Pierisin-6 in HPV Positive HeLa and HepG2 Cancer Cells is Mediated by the Caspase-3 Dependent Mitochondrial Pathway.

    abstract:BACKGROUND:To explore the cytotoxic and apoptotic activity of the pierisin-6 protein in HPV HeLa and HepG2 cell lines. METHODS:In this study, isolation, and purification of cytotoxic Prierisin-6 from the larvae of Pieris napi by affinity column chromatography techniques. Characterization of full-length mRNA of pierisi...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章

    doi:10.2174/1871520619666181127113848

    authors: Sarathbabu S,Marimuthu SK,Ghatak S,Vidyalakshmi S,Gurusubramanian G,Ghosh SK,Subramanian S,Zhang W,Kumar NS

    更新日期:2019-01-01 00:00:00

  • Fine Tuning Antibody Conjugation Methods using SNAP-tag Technology.

    abstract:BACKGROUND:Targeted imaging and therapy (theranostics) is a promising approach for the simultaneous improvement of cancer diagnosis, prognosis and management. Therapeutic and imaging reagents are coupled to tumor-targeting molecules such as antibodies, providing a basis for truly personalized medicine. However, the dev...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章

    doi:10.2174/1871520617666170213123737

    authors: Chouman K,Woitok M,Mladenov R,Kessler C,Weinhold E,Hanz G,Fischer R,Meinhold-Heerlein I,Bleilevens A,Gresch G,Haugg AM,Zeppernick F,Bauerschlag D,Maass N,Stickeler E,Kolberg K,Hussain AF

    更新日期:2017-01-01 00:00:00

  • Management of elderly patients with diffuse large B-cell lymphomas.

    abstract::Life expectancy has impressively increased over the past century and the US population over 65 years is rapidly growing, especially those over 80 years. In fact, persons older than 80 years have increased by more than 250% between the years 1960 and 2000, and it is expected that the population aged >75 years will trip...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/18715206113136660363

    authors: Ciancia R,Tirelli U,Ribera J,Spina M

    更新日期:2013-11-01 00:00:00

  • Latest Evidence on the Role of Multiparametric Magnetic Resonance Imaging in Active Surveillance for Insignificant Prostate Cancer: A Systematic Review.

    abstract:OBJECTIVE:Multiparametric Magnetic Resonance Imaging (mpMRI) has become a very useful tool in the management of PCa. Particularly, there is a great interest in using mpMRI for men on Active Surveillance (AS) for low risk PCa. The aim of this systematic review was to critically review the latest literature concerning th...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章

    doi:10.2174/1871520618666180105105413

    authors: Cantiello F,Manno S,Russo GI,Cimino S,Privitera S,Morgia G,Cicione A,Damiano R

    更新日期:2018-01-01 00:00:00

  • Episensitization: therapeutic tumor resensitization by epigenetic agents: a review and reassessment.

    abstract::Resistance to chemotherapy, biological and targeted therapies is an important clinical problem. Resistance can arise and/or be selected for multiple mechanisms of action. Unfortunately, acquired resistance to antitumor agents or regimens is nearly inevitable in all patients with metastatic disease. Until recently, it ...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/1871520614666140418144610

    authors: Oronsky B,Oronsky N,Knox S,Fanger G,Scicinski J

    更新日期:2014-01-01 00:00:00

  • Apoptosis-related BCL2-family members: Key players in chemotherapy.

    abstract::Classical chemotherapeutic agents such as mitotic inhibitors (spindle poisons), alkylating agents, antimetabolites, topoisomerase inhibitors, and anthracenediones (anthracyclines) inhibit DNA synthesis and mitosis, thereby killing or impeding the proliferation of rapidly dividing cells. During the last decade, targete...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/18715206113139990091

    authors: Kontos CK,Christodoulou MI,Scorilas A

    更新日期:2014-03-01 00:00:00

  • Heterocyclic chalcone analogues as potential anticancer agents.

    abstract::Chalcones, aromatic ketones and enones acting as the precursor for flavonoids such as Quercetin, are known for their anticancer effects. Although, parent chalcones consist of two aromatic rings joined by a three-carbon α,β-unsaturated carbonyl system, various synthetic compounds possessing heterocyclic rings like pyra...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:

    authors: Sharma V,Kumar V,Kumar P

    更新日期:2013-03-01 00:00:00

  • Anti-cancer Effect of Cyanidin-3-glucoside from Mulberry via Caspase-3 Cleavage and DNA Fragmentation in vitro and in vivo.

    abstract:BACKGROUND:Fruits of Morus alba L. (mulberry) have various bioactive compounds such as polyphenols and anthocyanins and used as a herbal medicine. However, the anti-cancer effects and molecular basis have not been elucidated. METHODS:We isolated the cyanidin-3-glucoside in various cultivar of mulberry by acidified-met...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章

    doi:10.2174/1871520617666170327152026

    authors: Cho E,Chung EY,Jang HY,Hong OY,Chae HS,Jeong YJ,Kim SY,Kim BS,Yoo DJ,Kim JS,Park KH

    更新日期:2017-11-24 00:00:00

  • The Use of Anthracyclines for Therapy of CNS Tumors.

    abstract::Despite being long lived, anthracyclines remain the "evergreen" drugs in clinical practice of oncology, showing a potent effect in inhibiting cell growth in many types of tumors, including brain neoplasms. Unfortunately, they suffer from a poor penetration into the brain when intravenously administered due to multidru...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/1871520615666150407155319

    authors: da Ros M,Iorio AL,Lucchesi M,Stival A,de Martino M,Sardi I

    更新日期:2015-01-01 00:00:00

  • Proliferation of breast cancer cells: regulation, mediators, targets for therapy.

    abstract::A majority of breast cancers (BC) display characteristics of epithelial cells and express estrogen receptors and/or HER-2 (a member of the epidermal growth factor receptor family). About one-fifth of BC is constituted of basal cells for which there is no specific category of proliferation regulators. Insulin-like grow...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/187152008786847747

    authors: Mester J,Redeuilh G

    更新日期:2008-12-01 00:00:00

  • Human Papillomavirus E7 Oncoprotein Promotes Proliferation and Migration through the Transcription Factor E2F1 in Cervical Cancer Cells.

    abstract:BACKGROUND:High-risk human papillomavirus (HR-HPV) persistent infection is the main cause of cervical cancer and its precancerous lesions. A previous study showed that HPV16 and HPV58 infections were the most common infection types in the local region. Some studies also declared that HPV58 E7 variants increased the ris...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章

    doi:10.2174/1871520620666201106085227

    authors: Tian S,Zhang L,Li Y,Cao D,Quan S,Guo Y,Yang X,Yang T

    更新日期:2020-11-05 00:00:00

  • Computational Approaches Towards Kinases as Attractive Targets for Anticancer Drug Discovery and Development.

    abstract:BACKGROUND:One of the major goals of computational chemists is to determine and develop the pathways for anticancer drug discovery and development. In recent past, high performance computing systems elicited the desired results with little or no side effects. The aim of the current review is to evaluate the role of com...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/1871520618666181009163014

    authors: Hameed R,Khan A,Khan S,Perveen S

    更新日期:2019-01-01 00:00:00

  • lncRNAs as Potential Targets in Small Cell Lung Cancer: MYC -dependent Regulation.

    abstract:BACKGROUND:Small Cell Lung Cancer (SCLC) is a highly aggressive malignancy. MYC family oncogenes are amplified and overexpressed in 20% of SCLCs, showing that MYC oncogenes and MYC regulated genes are strong candidates as therapeutic targets for SCLC. c-MYC plays a fundamental role in cancer stem cell properties and ma...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章

    doi:10.2174/1871520620666200721130700

    authors: Tokgun O,Tokgun PE,Inci K,Akca H

    更新日期:2020-01-01 00:00:00

  • Mechanisms of cancer prevention by green and black tea polyphenols.

    abstract::Drinking green tea is associated with decreased frequency of cancer development. This review outlines the wide range of mechanisms by which epigallocatechin gallate (ECGC) and other green and black tea polyphenols inhibit cancer cell survival. EGCG suppressed androgen receptor expression and signalling via several gro...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/187152006778226468

    authors: Beltz LA,Bayer DK,Moss AL,Simet IM

    更新日期:2006-09-01 00:00:00

  • 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid: a novel promising cancer chemopreventive agent.

    abstract::3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid is a secondary metabolite biosynthetically related to ferulic acid in which a geranyl chain is attached to the phenolic group, extracted from Acronychia baueri Schott (Fam. Rutaceae). In the last five years some of the pharmacological properties of 3-(4'-gerany...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/187152006778699149

    authors: Curini M,Epifano F,Genovese S,Marcotullio MC,Menghini L

    更新日期:2006-11-01 00:00:00

  • Analysis of Comparative Proteomic and Potent Targets of Peniciketal A in Human Acute Monocytic Leukemia.

    abstract:BACKGROUND:Peniciketal A (Pe-A), a spiroketal compound, shows potent anticancer activities in human acute monocytic leukemia. However, the detailed mechanisms and potent targets of Pe-A remain largely unexplored. Here, we investigated the differentially expressed proteins between the Pe-A-treated group and the control ...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章

    doi:10.2174/1871520619666190212124339

    authors: Gao X,Zhou Y,Sun H,Liu D,Zhang J,Zhang J,Liu W,Pan X

    更新日期:2019-01-01 00:00:00

  • Combination of Histone Deacetylase Inhibitor with Cu(II) 5,5- diethylbarbiturate Complex Induces Apoptosis in Breast Cancer Stem Cells: A Promising Novel Approach.

    abstract:BACKGROUND:Cancer stem cells (CSC) are subpopulation within the tumor that acts a part in the initiation, progression, recurrence, resistance to drugs and metastasis of cancer. It is well known that epigenetic changes lead to tumor formation in cancer stem cells and show drug resistance. Epigenetic modulators and /or t...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章

    doi:10.2174/1871520621666201207090702

    authors: Erkisa M,Aztopal N,Erturk E,Ulukaya E,Yilmaz VT,Ari F

    更新日期:2020-12-06 00:00:00

  • Novel molecular-targeted therapeutics for the treatment of cancer.

    abstract::Recently, intensive laboratory and preclinical studies have identified and validated therapeutic molecular targets in cancer, particularly the receptor tyrosine kinases, the intracellular pathways, and the genetic and epigenetic alterations, resulting in an unprecedented surge of novel, targeted therapies and therapeu...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/187152008784533099

    authors: Yasui H,Imai K

    更新日期:2008-06-01 00:00:00

  • Discovery of Novel N-alkyl 4-anilinofuro[2,3-b]quinoline Derivatives (CIL-102 Derivatives) Against Castration-resistant Human Prostate Cancers.

    abstract::A number of N-alkylated 4-anilinofuro[2,3-b]quinoline derivatives were synthesized and evaluated in vitro against PC-3, A549, and MCF-7 cancer cells and M-10 normal human mammary epithelial cells. The known antimitotic CIL-102 was moderately active against the growth of PC-3 prostate cancer cells with an IC50 value of...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章

    doi:10.2174/1871520615666150121122700

    authors: Lo WF,Chou YW,Tseng CH,Shiu YH,Chen YW,Yang SC,Chen YL,Lin MF,Tzeng CC

    更新日期:2015-01-01 00:00:00

  • Plant polyphenolics as anti-invasive cancer agents.

    abstract::Because invasion is, either directly or via metastasis formation, the main cause of death in cancer patients, development of efficient anti-invasive agents is an important research challenge. We have established a screening program for potentially anti-invasive compounds. The assay is based on organotypic confronting ...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/187152008783497037

    authors: Bracke ME,Vanhoecke BW,Derycke L,Bolca S,Possemiers S,Heyerick A,Stevens CV,De Keukeleire D,Depypere HT,Verstraete W,Williams CA,McKenna ST,Tomar S,Sharma D,Prasad AK,DePass AL,Parmar VS

    更新日期:2008-02-01 00:00:00

  • Design, Synthesis and Anti-breast Cancer Activity of Some Novel Substituted Isoxazoles as Anti-breast Cancer Agent.

    abstract:METHODS:A novel series of isoxazole (S21-S30) derivatives were designed, synthesized and screened for their anticancer activity against estrogen receptor-positive MCF-7 and negative MDA-MB-435 breast cancer cell lines. The synthesized derivative has the ability to inhibit the growth of the human breast cancer cell line...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章

    doi:10.2174/1871520618666171129153655

    authors: Mokale SN,Sakle NS,Bhavale SA,Lokwani DK,Shelke VR

    更新日期:2018-01-01 00:00:00

  • Sphingolipid modulation: a strategy for cancer therapy.

    abstract::Sphingolipids are membrane lipids that play important roles in the regulation of cell functions and homeostasis. Alterations in their metabolism have been associated with several pathologies. For this reason, therapeutic strategies based on the design of small molecules to restore sphingolipid levels to their physiolo...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/187152012800228643

    authors: Delgado A,Fabrias G,Bedia C,Casas J,Abad JL

    更新日期:2012-05-01 00:00:00

  • Oncologists' current opinion on the treatment of colon carcinoma.

    abstract::Colorectal cancer is a major global health problem with more than a million new cases diagnosed worldwide in 2005. In the United States, this malignancy is the third most common with 145,000 new cases and the second most lethal with 56,000 deaths in 2005. Unfortunately, preclinical diagnostic screening in the U.S. pop...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/187152007781668742

    authors: Majer M,Akerley W,Kuwada SK

    更新日期:2007-09-01 00:00:00

  • Preparation, Characterization and In-vitro Biological Evaluation of Novel Curcumin Derivatives as Cytotoxic and Apoptosis-Inducing Agents.

    abstract:BACKGROUND:Curcumin is a natural polyphenol and lead compound of the rhizomes of curcuma longa that it has been widely used for pharmacological activities. OBJECTIVE:In this study, series of novel derivatives of curcumin, which this group was linked to a 2-amino-4-phenylpyran-3-carbonitrile system, have been synthesiz...

    journal_title:Anti-cancer agents in medicinal chemistry

    pub_type: 杂志文章

    doi:10.2174/1871520620666201002111205

    authors: Arjomandi OK,Almasi S,Hosseinzadeh L,Kavoosi M,Adibi H

    更新日期:2020-10-02 00:00:00