Treatment approaches in elderly patients with head and neck cancer.

abstract：:Gestational trophoblastic neoplasia is a rare malignancy, which can occur after any type of pregnancy. The incidence varies according to the geographical location and ethnic origin. Although most patients with gestational trophoblastic neoplasia are cured by conventional chemotherapy and surgery, some suffer resistant...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Alazzam M,Tidy J,Hancock BW,Powers H

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:Elderly patients with metastatic colorectal cancer (mCRC) differ from the general population and are underrepresented in clinical trials. We, retrospectively, analyzed the safety and efficacy of XELOX regimen in the treatment of elderly patients affected by mCRC. PATIENTS AND METHODS:One-hundred-eleven consecu...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Berretta M,Aprile G,Nasti G,Urbani M,Bearz A,Lutrino S,Foltran L,Ferrari L,Talamini R,Fiorica F,Lleshi A,Canzonieri V,Lestuzzi C,Borsatti E,Fisichella R,Tirelli U

更新日期：2013-11-01 00:00:00

abstract：:Recently mutual interactions of chemotherapy and immunotherapy have been widely accepted, and several synergistic mechanisms have been elucidated as well. Although much attention has focused on the combination of DC vaccine and chemotherapy, there are still many problems remaining to be resolved, including the optimal...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Dong W,Wei R,Shen H,Ni Y,Meng L,Du J

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Vitamin D (VD) deficiency affects individuals of different ages in many countries. VD deficiency may be related to several diseases, including cancer. OBJECTIVE:This study aimed to review the relationship between VD deficiency and cancer. METHODS:We describe the proteins involved in cancer pathogenesis and...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Camara AB,Brandao IA

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Lung cancer is one of the most prevalent malignancies and thus the development of novel therapeutic agents for managing lung cancer is imperative. Tetrandrine, a bis-benzyltetrahydroisoquinoline alkaloid isolated from Stephania tetrandra S. Moore, has been found to exert cytotoxic effects on cancerous cells....

journal_title：Anti-cancer agents in medicinal chemistry

authors： Niu N,Qu T,Xu J,Lu X,Bodwell GJ,Zhao Z

更新日期：2019-01-01 00:00:00

abstract：:Life expectancy has impressively increased over the past century and the US population over 65 years is rapidly growing, especially those over 80 years. In fact, persons older than 80 years have increased by more than 250% between the years 1960 and 2000, and it is expected that the population aged >75 years will trip...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ciancia R,Tirelli U,Ribera J,Spina M

更新日期：2013-11-01 00:00:00

abstract：:Drinking green tea is associated with decreased frequency of cancer development. This review outlines the wide range of mechanisms by which epigallocatechin gallate (ECGC) and other green and black tea polyphenols inhibit cancer cell survival. EGCG suppressed androgen receptor expression and signalling via several gro...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Beltz LA,Bayer DK,Moss AL,Simet IM

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVE:Multiparametric Magnetic Resonance Imaging (mpMRI) has become a very useful tool in the management of PCa. Particularly, there is a great interest in using mpMRI for men on Active Surveillance (AS) for low risk PCa. The aim of this systematic review was to critically review the latest literature concerning th...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Cantiello F,Manno S,Russo GI,Cimino S,Privitera S,Morgia G,Cicione A,Damiano R

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Colorectal cancer is among the leading causes of death worldwide. The incidence of deaths is expected to be 11.4 million in 2030. OBJECTIVE:We aimed to evaluate the in vitro and in vivo antioxidant and antitumor activities of a novel Bithiophene- Fluorobenzamidine (BFB) against DMH-induced colorectal cancer...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Abdel-Rasol M,El-Beih NM,Yahya SMM,Ismail MA,El-Sayed WM

更新日期：2020-01-01 00:00:00

abstract：:Emetine and CGP-74514A have previously shown antitumor activity in neuroendocrine tumor cell lines. The aim of this study was to investigate the cytotoxic activity of the drugs in a three-dimensional model and to study if the mechanism of the cytotoxic activity was induction of apoptosis. An in vitro hollow fiber mode...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Larsson DE,Hassan SB,Oberg K,Granberg D

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) is the main bioactive component of Brazilian green propolis, and possesses, among other things, anticancer properties. However, to the best of our knowledge, there are no studies of artepillin C in cervical cancer. METHOD:To explore a new therapeutic candid...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Souza RP,Bonfim-Mendonça PS,Damke GMZF,de-Assis Carvalho ARB,Ratti BA,Dembogurski DSO,da-Silva VRS,Silva SO,Da-Silva DB,Bruschi ML,Maria-Engler SS,Consolaro MEL

更新日期：2018-01-01 00:00:00

abstract：:β-Glucans are polysaccharides of β-D-glucose extracted from the cell walls of different species of mushrooms, yeast, oat, barley, seaweeds, algae and bacteria. Modern biomedical research has identified β-glucans as biological response modifiers (BRM) with anti-tumor properties that elicit potent immune responses throu...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Albeituni SH,Yan J

更新日期：2013-06-01 00:00:00

abstract：:As cancers are one of the most important causes of human morbidity and mortality worldwide, researchers try to discover novel compounds and therapeutic approaches to decrease survival of cancer cells, angiogenesis, proliferation and metastasis. In the last decade, use of special phytochemical compounds and flavonoids ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Hosseinzadeh E,Hassanzadeh A,Marofi F,Alivand MR,Solali S

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The DNA repair enzyme tyrosyl-DNA-phosphodiesterase 1 (TDP1) is a current inhibition target to improve the efficacy of cancer chemotherapy. Previous studies showed that compounds combining adamantane and monoterpenoid fragments are active against TDP1 enzyme. This investigation is focused on th...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Mozhaitsev ES,Zakharenko AL,Suslov EV,Korchagina DV,Zakharova OD,Vasil'eva IA,Chepanova AA,Black E,Patel J,Chand R,Reynisson J,Leung IKH,Volcho KP,Salakhutdinov NF,Lavrik OI

更新日期：2019-01-01 00:00:00

abstract：:The study of anticancer properties from natural products has regained popularity as natural molecules provide a high diversity of chemical structures with specific biological and medicinal activity. Based on a documented library of the most common medicinal plants used by the indigenous people of North America, we scr...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Benzina S,Harquail J,Jean S,Beauregard AP,Colquhoun CD,Carroll M,Bos A,Gray CA,Robichaud GA

更新日期：2015-01-01 00:00:00

abstract：:Sphingolipids are membrane lipids that play important roles in the regulation of cell functions and homeostasis. Alterations in their metabolism have been associated with several pathologies. For this reason, therapeutic strategies based on the design of small molecules to restore sphingolipid levels to their physiolo...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Delgado A,Fabrias G,Bedia C,Casas J,Abad JL

更新日期：2012-05-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a cancer with extremely poor prognosis. This review discusses the pathological characteristics of multi-step hepatocarcinogenesis, tumor growth, invasion and metastasis, the expression of matrix metalloproteinases (MMPs) and their inhibitors via signal transduction in relation to dedi...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Okazaki I,Inagaki Y

更新日期：2012-09-01 00:00:00

abstract：:Resistance to chemotherapy, biological and targeted therapies is an important clinical problem. Resistance can arise and/or be selected for multiple mechanisms of action. Unfortunately, acquired resistance to antitumor agents or regimens is nearly inevitable in all patients with metastatic disease. Until recently, it ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Oronsky B,Oronsky N,Knox S,Fanger G,Scicinski J

更新日期：2014-01-01 00:00:00

abstract：:Cancer is the second leading cause of death, preceded only by cardiovascular diseases, and there is epidemiological evidence that demonstrate this tendency is emerging worldwide. Brazil has an extensive vegetal biodiversity with more than 55,000 species listed. Such biodiversity collaborates with the finding of compou...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Fuzer AM,Filho JC,Becceneri AB,Dos Santos DA,da Silva MF,Vieira PC,Fernandes JB,Selistre-de-Araujo HS,Cazal CM,Cominetti MR

更新日期：2013-12-01 00:00:00

abstract：:The metabolism of alkylating agents is accompanied by the generation of reactive oxygen species. The aim of this study was to treat estrogen receptor-positive and estrogen receptor-negative human breast cancer cells, MCF-7 and MDA-MB-231, respectively, with cisplatin and five different berenil-platinum (II) complexes,...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Agnieszka G,Ewa A,Anna B,Krzysztof B,Monika C,Elżbieta S

更新日期：2014-01-01 00:00:00

abstract：:Phospholipase A2 (PLA2), Cyclooxygenase (COX) and 5-Lipoxygenase (5-LOX) are arachidonic acid metabolizing enzymes and their inhibitors have been developed as therapeutic molecules for cancer and inflammation related disorders. In the present study, PLA2, COX 1&2 and 5-LOX inhibitory studies of Borassus flabellifer se...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Yarla NS,Azad R,Basha M,Rajack A,Kaladhar DS,Allam BK,Pragada RR,Singh KN,K SK,Pallu R,Parimi U,Bishayee A,Duddukuri GR

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND & PURPOSE:In evaluating new drugs for the treatment of various types of cancer, investigations have been made to discover a variety of anti-tumor compounds with less side effects on normal cells. Investigations have shown that the heterodimers S100A8 and S100A9 inhibit the enzyme casein kinase 2 and then pre...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Charkhizadeh S,Imani M,Gheibi N,Shabaani F,Nikpajouh A,Rezvany MR

更新日期：2020-01-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDA) remains one of the deadliest types of cancers. Median survival rate is very poor with the currently available chemotherapeutical regimens. Therefore, discovery of new antineoplastic agents against PDA is one of the focused areas of contemporary research. The present study was und...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Goswami A,Shah BA,Batra N,Kumar A,Guru SK,Bhushan S,Malik FA,Joshi A,Singh J

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Obesity is characterized by increased long chain fatty acids (LCFA) uptake and impaired lipid metabolism in hepatocytes. Consequently, an enhanced intracellular lipid content, including sphingolipids, may lead to lipotoxicity. It is believed that resveratrol (RSV), one of the most extensively studied plant-d...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Charytoniuk T,Harasim-Symbor E,Polak A,Drygalski K,Berk K,Chabowski A,Konstantynowicz-Nowicka K

更新日期：2019-01-01 00:00:00

abstract：:Backgroun/Methods: In attempt to develop new potent anti-tumor agents, a series of quinoxaline derivatives was designed and synthesized. The novel compounds were tested in vitro for their anti-proliferative activities against HePG-2, MCF-7 and HCT-116 cell lines. Additionally, DNA binding affinities as well as DNA-top...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Eissa IH,El-Naggar AM,El-Sattar NEAA,Youssef ASA

更新日期：2018-01-01 00:00:00

abstract：:The hypothesis that vitamin D deficiency increases the risk of clinical prostate cancer has stimulated an extensive body of research. Ecologic studies have shown that mortality rates from prostate cancer are inversely correlated with levels of ultraviolet radiation, the principal source of vitamin D. Human prostate ce...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Schwartz GG

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Silver nanoparticles (AgNPs) are one of the most investigated nanostructures in recent years, which gives more challenging and promising qualities in different biomedical applications. The AgNPs synthesized by the green approach provide potential healthcare benefits over chemical approaches, including improv...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Mishra V,Nayak P,Singh M,Tambuwala MM,Aljabali AA,Chellappan DK,Dua K

更新日期：2020-09-18 00:00:00

abstract：:Effective elicitation of endogenous immunity is associated with improved prognosis for cancer patients. Clinical evidence in hematological and solid cancers shows that intratumoral injection of immunostimulatory genes primes and augments endogenous T cell responses. The ability of pro-inflammatory chemokines/cytokines...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Phan-Lai V,Kievit FM,Florczyk SJ,Wang K,Disis ML,Zhang M

更新日期：2014-02-01 00:00:00

abstract：:Primary liver cancer is one of the most commonly occurring cancers worldwide. Hepatocellular carcinoma (HCC) represents the majority of primary liver cancer and is the 3rd most common cause of cancer-related deaths globally. Survival rates of patients with HCC are dependent upon early detection as concomitant liver dy...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Sokolowski KM,Koprowski S,Kunnimalaiyaan S,Balamurugan M,Gamblin TC,Kunnimalaiyaan M

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Colorectal Cancer (CRC) is one of the most common fatal diseases with high morbidity. Alteration of glucose metabolism is one of the hallmarks in the development of CRC. Glucose Transporter 1 (GLUT1) is a key rate-limiting protein in hyperactive glucose metabolism and up-regulated in CRC, however, the underl...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Kuai XY,Lei ZY,Liu XS,Shao XY

更新日期：2020-01-01 00:00:00