Abstract：
:Evidence supports that a variety of cancers are sparked by the growth of cells that exhibit characteristics of stem cells. Such cancer-initiating cells are capable of populating a tumor with a heterogeneous group of daughter cells while still maintaining the ability to self-renew. Several groups have recently reported the identification of cancer-initiating cells in ovarian cancer, the most lethal gynecologic malignancy. Epithelial ovarian cancer comprises 90% of cancers of the ovary and consists of four major histologic types, each bearing some resemblance to tissues in the peritoneal cavity. Although epithelial ovarian cancer has traditionally been thought to originate from the single layer of cells surrounding each ovary, new findings suggest that many of these cancers derive from Müllerian epithelium. This raises questions about the origin of ovarian cancer-initiating cells, and if there may be more than one source. Despite the initial effectiveness of primary therapy against advanced stage ovarian cancer, most of these cases recur, months to years following diagnosis. The cause of disease recurrence is unknown, but may involve cancer-initiating cells that survive chemotherapy and enter a period of dormancy while residing in as-yet undefined niches within the body before being triggered to initiate renewed growth. Herein the nature of these cells is explored as well as novel approaches for therapeutic targeting.
journal_name
Anticancer Agents Med Chemjournal_title
Anti-cancer agents in medicinal chemistryauthors
Murphy SKdoi
10.2174/187152010790909272subject
Has Abstractpub_date
2010-02-01 00:00:00pages
157-63issue
2eissn
1871-5206issn
1875-5992pii
BSP/ACAMC/E-Pub/ 00061journal_volume
10pub_type
杂志文章,评审abstract：:Epigenetic modifications can affect numerous mechanisms used by neoplastic cells to evade immune control. In melanoma epigenetic defects, caused by dysregulations in the expression of genome writers, erasers, or readers, play a significant role in the reduced expression of molecules required for efficient immune recog...
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章,评审
doi：10.2174/1871520616666160425110401
更新日期：2017-01-01 00:00:00
abstract：:Acetogenins (ACG) are naturally occurring compounds that are chemically one of the least investigated families. In the review, we have provided a comprehensive listing of 133 of these compounds for which anti-tumor activity has been documented within the literature. We have compiled and studied their chemical structur...
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章,评审
doi：10.2174/1871520615666150629101827
更新日期：2015-01-01 00:00:00
abstract：:Cyclophosphamide (CPA) remains one of the most widely prescribed anticancer drugs. It is also used in the treatment of rheumatoid arthritis, childhood nephrotic syndrome and systemic lupus erythematosus. It is a potent immunosuppressive agent. It is commonly used in blood and bone marrow transplantation. With the grow...
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章,评审
doi：10.2174/1871520616666161206150421
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Cinnamic acid (CA), also known as 3-phenyl-2-propenoic acid, is a naturally occurring aromatic fatty acid found commonly in cinnamon, grapes, tea, cocoa, spinach and celery. Various studies have identified CA to have anti-proliferative action on glioblastoma, melanoma, prostate and lung carcinoma cells. OBJ...
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章
doi：10.2174/1871520620666200807222248
更新日期：2020-08-07 00:00:00
abstract：BACKGROUND:Esophageal cancer responds poorly to traditional therapies, and novel treatments are needed. The phytochemical curcumin is a potential treatment for Esophageal Squamous Cell Carcinoma (ESCC). A curcumin metabolite, tetrahydrocurcumin (THCUR), has anti-cancer effects and greater bioavailability than curcumin....
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章
doi：10.2174/1871520619666190116141448
更新日期：2019-01-01 00:00:00
abstract：:A majority of breast cancers (BC) display characteristics of epithelial cells and express estrogen receptors and/or HER-2 (a member of the epidermal growth factor receptor family). About one-fifth of BC is constituted of basal cells for which there is no specific category of proliferation regulators. Insulin-like grow...
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章,评审
doi：10.2174/187152008786847747
更新日期：2008-12-01 00:00:00
abstract：BACKGROUND:Silver nanoparticles (AgNPs) are one of the most investigated nanostructures in recent years, which gives more challenging and promising qualities in different biomedical applications. The AgNPs synthesized by the green approach provide potential healthcare benefits over chemical approaches, including improv...
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章
doi：10.2174/1871520620666200918111024
更新日期：2020-09-18 00:00:00
abstract：:In the present review, the discovery and development of quinazoline as tyrosine kinase inhibitors has been described. The synthesis of most potent quinazoline inhibitors of EGFR, VEGFR and PDGRF has been discussed. Structure activity relationship for quinazoline as tyrosine kinase inhibitors has been established. It w...
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章,评审
doi：10.2174/1871520610909030246
更新日期：2009-03-01 00:00:00
abstract：:To search for novel anticancer agents, we designed and synthesized a series of new triazolyl berberine derivatives. The evaluation of all the synthesized compounds and their anticancer activities against a panel of four human cancer cell lines including MCF-7 (breast), MCF-7/ADR (breast), SW-1990 (pancreatic), SMMC-77...
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章
doi：
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Cancer stem cells (CSC) are subpopulation within the tumor that acts a part in the initiation, progression, recurrence, resistance to drugs and metastasis of cancer. It is well known that epigenetic changes lead to tumor formation in cancer stem cells and show drug resistance. Epigenetic modulators and /or t...
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章
doi：10.2174/1871520621666201207090702
更新日期：2020-12-06 00:00:00
abstract：:Cancer is one of the most fatal diseases in the world and it has been years that finding new drugs and chemotherapeutic techniques with lowest side effects become one of the most important challenging matters needs really hard efforts. Chlorambucil (CBL), an ancient direct-acting alkylating anticancer agent, is common...
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章
doi：10.2174/18715206113139990132
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) is the main bioactive component of Brazilian green propolis, and possesses, among other things, anticancer properties. However, to the best of our knowledge, there are no studies of artepillin C in cervical cancer. METHOD:To explore a new therapeutic candid...
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章
doi：10.2174/1871520618666180604092930
更新日期：2018-01-01 00:00:00
abstract：:A large group of aminoalkyl and aminoalkanol derivatives of selected dicarboximides were synthesized and characterized by 1HNMR, 13CNMR and ESI MS spectra analysis. The thirty nine new compounds were tested for their cytotoxic properties in human chronic (K562), acute leukemia (HL-60), and cervical cancer cells (HeLa)...
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章
doi：10.2174/1871520616666160223114318
更新日期：2016-01-01 00:00:00
abstract：AIM:This study aimed to characterize the cellular basis of the platinum cytotoxicity of two novel platinum complexes, 3Pt and 1Pt, in comparison with that of cisplatin. 3Pt comprises anionic phosphate moieties, while 1Pt comprises neutral aromatic ligands. METHODS:We compared the cytotoxic potency of 3Pt and 1Pt with ...
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章
doi：10.2174/1871520615666141216151547
更新日期：2015-01-01 00:00:00
abstract：:Cancer is the second leading cause of death, preceded only by cardiovascular diseases, and there is epidemiological evidence that demonstrate this tendency is emerging worldwide. Brazil has an extensive vegetal biodiversity with more than 55,000 species listed. Such biodiversity collaborates with the finding of compou...
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章
doi：10.2174/18715206113139990314
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:Ruthenium-based anti-cancer compounds are proposed as viable alternatives that might circumvent the disadvantages of platinum-based drugs, the only metallodrugs in clinical use for chemotherapy. Organometallic complexes in particular hold great potential as alternative therapeutic agents since their cytotoxi...
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章
doi：
更新日期：2017-01-01 00:00:00
abstract：:Recently mutual interactions of chemotherapy and immunotherapy have been widely accepted, and several synergistic mechanisms have been elucidated as well. Although much attention has focused on the combination of DC vaccine and chemotherapy, there are still many problems remaining to be resolved, including the optimal...
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章,评审
doi：10.2174/1871520615666150907094139
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Colorectal cancer is among the leading causes of death worldwide. The incidence of deaths is expected to be 11.4 million in 2030. OBJECTIVE:We aimed to evaluate the in vitro and in vivo antioxidant and antitumor activities of a novel Bithiophene- Fluorobenzamidine (BFB) against DMH-induced colorectal cancer...
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章
doi：10.2174/1871520619666191021162411
更新日期：2020-01-01 00:00:00
abstract：:High grade gliomas (HGGs) are primary CNS cancers with more than 95% of patients experiencing tumor recurrence following radiation therapy, chemotherapy, and/or an anti-angiogenic therapy. Populations of glioma 'stem-like' cells (GSCs) exist in both proliferative and non-proliferative states and are capable of tumor r...
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章,评审
doi：
更新日期：2017-01-01 00:00:00
abstract：AIM:The aim of our research work is the synthesis of tetrahydroisoquinoline derivatives as anti-Angiogenesis and anti-cancer agents. BACKGROUND:Cancer is the second leading cause of deaths in United States. The current recovery rate from the advanced treatment for the cancer is unacceptably low. Therefore, identificat...
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章
doi：10.2174/1871520621666210112122913
更新日期：2021-01-12 00:00:00
abstract：:The kinesin spindle protein (KSP, also known as Hs Eg5) plays an essential part in the proper separation of spindle poles and the correct formation of bipolar mitotic spindle during mitosis. Inhibition of this protein results in cells apoptosis followed by mitotic arrest and the formation of characteristic monoaster s...
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章,评审
doi：
更新日期：2008-08-01 00:00:00
abstract：BACKGROUND:Colorectal Cancer (CRC) is one of the most common fatal diseases with high morbidity. Alteration of glucose metabolism is one of the hallmarks in the development of CRC. Glucose Transporter 1 (GLUT1) is a key rate-limiting protein in hyperactive glucose metabolism and up-regulated in CRC, however, the underl...
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章
doi：10.2174/1871520620666200318094618
更新日期：2020-01-01 00:00:00
abstract：:Histone deacetylase inhibitors (HDACIs) represent one of the most promising, recently developed classes of anticancer agents already approved by the U.S. FDA. The effectiveness of these new drugs has currently being explored in a variety of cancer cell lines, in vitro, animal models, in vivo, as well as in clinical tr...
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章,评审
doi：
更新日期：2013-03-01 00:00:00
abstract：:Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that resides at the sites of focal adhesions. The 125 kDa FAK protein is encoded by the FAK gene located on human chromosome 8q24. Structurally, FAK consists of an amino-terminal regulatory FERM domain, a central catalytic kinase domain, and a carboxy-termi...
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章,评审
doi：10.2174/187152010794728648
更新日期：2010-12-01 00:00:00
abstract：BACKGROUND:T-LAK cell-originated protein kinase (TOPK) belongs to the serine/threonine protein kinase family. It is highly expressed in RPMI7951 melanoma cells. Scutellarin (SCU) is an active ingredient extracted from Erigeron breviscapus (Vant.) Hand.-Mazz. Its main physiological functions are related to its anti-infl...
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章
doi：10.2174/1871520620666200811112156
更新日期：2020-08-10 00:00:00
abstract：OBJECTIVE AND METHOD:A new series of benzothiazole-piperazine derivatives was synthesized and a complete chemical characterization of the novel compounds was provided. In vitro cytotoxic activities were screened against colorectal (HCT-116), breast (MCF-7) and hepatocellular (Huh7) cancer cell lines by Sulforhodamine B...
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章
doi：10.2174/1871520617666170412153604
更新日期：2017-01-01 00:00:00
abstract：:The phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway is a key regulator of authophagy. Natural products show anticancer activity and often induce apoptosis or autophagy. The crosstalk between these two types of cell death makes autophagy an interesting target since drugs targetin...
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章,评审
doi：10.2174/18715206113139990130
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Indoleamine-2,3-dioxygenase 1 (IDO1), which catalyzes the degradation of L-tryptophan (L-Trp) to N-formyl kynurenine (NFK) in the first and rate-limiting step of Kynurenine (KYN) pathway has been identified as a promising therapeutic target for cancer immunotherapy. The small molecule Epacadost...
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章
doi：10.2174/1871520620666200604121225
更新日期：2020-01-01 00:00:00
abstract：:Recently, intensive laboratory and preclinical studies have identified and validated therapeutic molecular targets in cancer, particularly the receptor tyrosine kinases, the intracellular pathways, and the genetic and epigenetic alterations, resulting in an unprecedented surge of novel, targeted therapies and therapeu...
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章,评审
doi：10.2174/187152008784533099
更新日期：2008-06-01 00:00:00
abstract：BACKGROUND:Cassane-type diterpenoids are widely distributed in the medical plants of genus Caesalpinia. To date, plenty of cassane diterpenoids have been isolated from the genus Caesalpinia, and some of them were documented to exhibit multiple biological activities. However, the effects of these compounds on autophagy ...
journal_title：Anti-cancer agents in medicinal chemistry
pub_type： 杂志文章
doi：10.2174/1871520620666200414095828
更新日期：2020-01-01 00:00:00
