The Antitumor Activity of a Novel Fluorobenzamidine against Dimethylhydrazine- Induced Colorectal Cancer in Rats.

abstract：:The therapeutic potential of targeting p21-Activated Kinases (PAK1 - 6) for the treatment of cancer has recently gained traction in the biotech industry. Many pharmaceutically-viable ATP competitive inhibitors have been through different stages of pre-clinical development with only a single compound evaluated in human...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Senapedis W,Crochiere M,Baloglu E,Landesman Y

更新日期：2016-01-01 00:00:00

abstract：:Sphingolipids are major constituents of the cells with emerging roles in the regulation of cellular processes. Deregulation of sphingolipid metabolism is reflected as various pathophysiological conditions including metabolic disorders and several forms of cancer. Ceramides, ceramide-1-phosphate (C1P), glucosyl ceramid...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ekiz HA,Baran Y

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Small Cell Lung Cancer (SCLC) is a highly aggressive malignancy. MYC family oncogenes are amplified and overexpressed in 20% of SCLCs, showing that MYC oncogenes and MYC regulated genes are strong candidates as therapeutic targets for SCLC. c-MYC plays a fundamental role in cancer stem cell properties and ma...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Tokgun O,Tokgun PE,Inci K,Akca H

更新日期：2020-01-01 00:00:00

abstract：:Glioblastoma Multiforme (GMB) is the most aggressive primary brain tumor with poor survival rates and universal recurrence despite aggressive treatments. Recent research suggested that GBM has multiple glioma cell populations, some of which are organized in a stem cell hierarchical order with different stages of diffe...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Alexandru-Abrams D,Jadus MR,Hsu FP,Stathopoulos A,Bota DA

更新日期：2014-01-01 00:00:00

abstract：:Histone deacetylase inhibitors (HDACIs) represent one of the most promising, recently developed classes of anticancer agents already approved by the U.S. FDA. The effectiveness of these new drugs has currently being explored in a variety of cancer cell lines, in vitro, animal models, in vivo, as well as in clinical tr...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Katafygiotis P,Giaginis C,Patsouris E,Theocharis S

更新日期：2013-03-01 00:00:00

abstract：:The study of anticancer properties from natural products has regained popularity as natural molecules provide a high diversity of chemical structures with specific biological and medicinal activity. Based on a documented library of the most common medicinal plants used by the indigenous people of North America, we scr...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Benzina S,Harquail J,Jean S,Beauregard AP,Colquhoun CD,Carroll M,Bos A,Gray CA,Robichaud GA

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The genetic heterogeneity of tumor cells and the development of therapy-resistant cancer cells in addition to the high cost necessitate the continuous development of novel targeted therapies. METHODS:In this regard, 14 novel benzoxazinone derivatives were synthesized and examined for anticancer activity aga...

journal_title：Anti-cancer agents in medicinal chemistry

authors： El-Hashash MA,Ali AT,Hussein RA,El-Sayed WM

更新日期：2019-01-01 00:00:00

abstract：:Common therapy of cancer such as chemotherapy have various side effects for the patients. In recent studies, new therapeutic approaches in cancer treatment are adjuvant therapy, along with a reduction in side effects of chemotherapy drugs. Treatment by herbal medicines may have some advantages over treatment with sing...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Tajaldini M,Asadi J

更新日期：2020-07-20 00:00:00

abstract：:Urothelial cell carcinoma is one of the most common malignancies of the urinary tract. The standard of care, intravesical chemo- and immunotherapy, while effective, is associated with a considerable side-effect profile and approximately 30% of patients either fail to respond to treatment or suffer recurrent disease wi...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Carradori S,Cristini C,Secci D,Gulia C,Gentile V,Di Pierro GB

更新日期：2012-07-01 00:00:00

abstract：:For thousands of years medicine and natural products have been closely linked through the use of traditional medicines and natural poisons. Mushrooms have an established history of use in traditional oriental medicine, where most medicinal mushroom preparations are regarded as a tonic, that is, they have beneficial he...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ferreira IC,Vaz JA,Vasconcelos MH,Martins A

更新日期：2010-06-01 00:00:00

abstract：:The metabolism of alkylating agents is accompanied by the generation of reactive oxygen species. The aim of this study was to treat estrogen receptor-positive and estrogen receptor-negative human breast cancer cells, MCF-7 and MDA-MB-231, respectively, with cisplatin and five different berenil-platinum (II) complexes,...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Agnieszka G,Ewa A,Anna B,Krzysztof B,Monika C,Elżbieta S

更新日期：2014-01-01 00:00:00

abstract：:Indole compounds, found in cruciferous vegetables, are potent anti-cancer agents. Studies with indole-3-carbinol (I3C) and its dimeric product, 3,3'-diindolylmethane (DIM) suggest that these compounds have the ability to deregulate multiple cellular signaling pathways, including PI3K/Akt/mTOR signaling pathway. These ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ahmad A,Biersack B,Li Y,Kong D,Bao B,Schobert R,Padhye SB,Sarkar FH

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Angiogenesis is physiological process in embryogenesis, organ development, endometrial vasculature in menstrual cycle and wound healing. Angiogenesis has also been associated with several pathological conditions such as cancer, arthritis, atherosclerosis, etc. Out of the many growth factor responsible for an...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Bhanushali U,Kalekar-Joshi S,Kulkarni-Munshi R,Yellanki S,Medishetty R,Kulkarni P,Chelakara RS

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:In recent years, targeted cancer treatment methods at various molecular levels have been developed for Non-Small Cell Lung Cancer (NSCLC), one of two major subtypes of lung cancer. miRNAbased clinical trials are currently the preferred targeted therapeutic strategy. Also, ceRNAs (competing endogenous RNA) wo...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ergun S,Güney S,Temiz E,Petrovic N,Gunes S

更新日期：2018-01-01 00:00:00

abstract：:In both bacteria and eukaryotes the alkylated, oxidized, and deaminated bases and depurinated lesions are primarily repaired via an endogenous preventive pathway, i.e. base excision repair (BER). Radiation therapy and chemotherapy are two important modes of cancer treatment. Many of those therapeutic agents used in th...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Adhikari S,Choudhury S,Mitra PS,Dubash JJ,Sajankila SP,Roy R

更新日期：2008-05-01 00:00:00

abstract：:Backgroun/Methods: In attempt to develop new potent anti-tumor agents, a series of quinoxaline derivatives was designed and synthesized. The novel compounds were tested in vitro for their anti-proliferative activities against HePG-2, MCF-7 and HCT-116 cell lines. Additionally, DNA binding affinities as well as DNA-top...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Eissa IH,El-Naggar AM,El-Sattar NEAA,Youssef ASA

更新日期：2018-01-01 00:00:00

abstract：:The concept of Ayurvedic expert guided drug discovery and development is defined and put to test systematically for the first time in literature. Western Science has explored only ~5% of the approximately 25,000 species of higher plants for drug leads. The ancient medical science of Ayurveda has however employed a muc...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Sun C,Nirmalananda S,Jenkins CE,Debnath S,Balambika R,Fata JE,Raja KS

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:The network interactions link human disease proteins to regulatory cellular pathways leading to better understanding of protein functions and cellular processes. Revealing the network of signaling pathways in cancer through protein-protein interactions at molecular level enhances our understanding of Hepatoc...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ranjpour M,Katare DP,Wajid S,Jain SK

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Cancer is the second leading cause of death globally. Hydrazone and hydrazone derivatives have high activity, and for this reason, these compound are greatly used by researchers to synthesize new anti-cancer drug. The aim of this research work is to synthesize novel anticancer agents. METHODS:New hydrazone ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ünver H,Berber B,Demirel R,Koparal AT

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Peniciketal A (Pe-A), a spiroketal compound, shows potent anticancer activities in human acute monocytic leukemia. However, the detailed mechanisms and potent targets of Pe-A remain largely unexplored. Here, we investigated the differentially expressed proteins between the Pe-A-treated group and the control ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Gao X,Zhou Y,Sun H,Liu D,Zhang J,Zhang J,Liu W,Pan X

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:To explore the cytotoxic and apoptotic activity of the pierisin-6 protein in HPV HeLa and HepG2 cell lines. METHODS:In this study, isolation, and purification of cytotoxic Prierisin-6 from the larvae of Pieris napi by affinity column chromatography techniques. Characterization of full-length mRNA of pierisi...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Sarathbabu S,Marimuthu SK,Ghatak S,Vidyalakshmi S,Gurusubramanian G,Ghosh SK,Subramanian S,Zhang W,Kumar NS

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Multi-kinase inhibitor sorafenib showed dramatic effects in acute myeloid leukemia (AML) cells harboring fms-related tyrosine kinase 3-internal tandem duplication (FLT3-ITD) mutation. However, FLT3-ITD mutation only occurs in 25% of AML cases. The therapeutic effects of sorafenib in AML patients without FLT3...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Yang N,Gu Z,Liu Z,Huang W,Wang S,Wang L,Gao C

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:One of the major goals of computational chemists is to determine and develop the pathways for anticancer drug discovery and development. In recent past, high performance computing systems elicited the desired results with little or no side effects. The aim of the current review is to evaluate the role of com...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Hameed R,Khan A,Khan S,Perveen S

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Cancer is the second leading cause of mortality worldwide. Despite several advances made in the treatment strategies, the cure for cancer remains still a challenge. Currently used treatment modalities pose several side effects and remain ineffective in the later stages. Thiazolidinediones (TZDs) have been sh...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Uwabagira N,Sarojini BK,Prabhu A

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The DNA repair enzyme tyrosyl-DNA-phosphodiesterase 1 (TDP1) is a current inhibition target to improve the efficacy of cancer chemotherapy. Previous studies showed that compounds combining adamantane and monoterpenoid fragments are active against TDP1 enzyme. This investigation is focused on th...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Mozhaitsev ES,Zakharenko AL,Suslov EV,Korchagina DV,Zakharova OD,Vasil'eva IA,Chepanova AA,Black E,Patel J,Chand R,Reynisson J,Leung IKH,Volcho KP,Salakhutdinov NF,Lavrik OI

更新日期：2019-01-01 00:00:00

abstract：:The importance of monoclonal antibodies in oncology has increased drastically following the discovery of Milstein and Kohler. Since the first approval of the monoclonal antibody, i.e. Rituximab in 1997 by the FDA, there was a decline in further applications but this number has significantly increased over the last thr...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Kaur N,Goyal A,Sindhu RK

更新日期：2020-01-01 00:00:00

abstract：:A novel process for the preparation of two ketomethylenic antifolates, 2-(2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-amino]- phenyl}-2-oxo-ethyl) pentanedioic acid and 2-(2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-phenyl}-2-oxo-ethyl) pentanedioic acid is described herein. Both compounds were compared with met...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Stoicescu DF,Rotaru M

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Indoleamine-2,3-dioxygenase 1 (IDO1), which catalyzes the degradation of L-tryptophan (L-Trp) to N-formyl kynurenine (NFK) in the first and rate-limiting step of Kynurenine (KYN) pathway has been identified as a promising therapeutic target for cancer immunotherapy. The small molecule Epacadost...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Xia Z,Nan Y,Liu C,Lin G,Gu K,Chen C,Zhao W,Ju D,Dong X

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Functional foods, neutraceuticals and natural antioxidants have established their potential roles in the protection of human health and diseases. Thymoquinone (TQ), the main bioactive component of Nigella sativa seeds (black cumin seeds), a plant derived neutraceutical was used by ancient Egyptians because o...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Sundaravadivelu S,Raj SK,Kumar BS,Arumugamand P,Ragunathan PP

更新日期：2019-01-01 00:00:00

abstract：:Replication fork reversal and restart has gained immense interest as a central response mechanism to replication stress following DNA damage. Although the exact mechanism of fork reversal has not been elucidated precisely, the involvement of diverse pathways and different factors has been demonstrated, which are centr...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Jain CK,Mukhopadhyay S,Ganguly A

更新日期：2020-01-01 00:00:00