Design, Synthesis and Evaluation of 5-pyridin-4-yl-2-thioxo-[1,3,4]oxadiazol-3-yl Derivatives as Anti-angiogenic Agents Targeting VEGFR-2.

abstract：:Of late medicinal plants and functional foods rich in bioactive phytochemicals have received growing attention as potential agents for cancer chemoprevention. Accumulating evidence from epidemiological studies as well as laboratory data supports the anticancer properties of garlic widely used as a medicinal herb and s...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Nagini S

更新日期：2008-04-01 00:00:00

abstract：:β-Glucans are polysaccharides of β-D-glucose extracted from the cell walls of different species of mushrooms, yeast, oat, barley, seaweeds, algae and bacteria. Modern biomedical research has identified β-glucans as biological response modifiers (BRM) with anti-tumor properties that elicit potent immune responses throu...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Albeituni SH,Yan J

更新日期：2013-06-01 00:00:00

abstract：:For thousands of years medicine and natural products have been closely linked through the use of traditional medicines and natural poisons. Mushrooms have an established history of use in traditional oriental medicine, where most medicinal mushroom preparations are regarded as a tonic, that is, they have beneficial he...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ferreira IC,Vaz JA,Vasconcelos MH,Martins A

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:Elderly patients with metastatic colorectal cancer (mCRC) differ from the general population and are underrepresented in clinical trials. We, retrospectively, analyzed the safety and efficacy of XELOX regimen in the treatment of elderly patients affected by mCRC. PATIENTS AND METHODS:One-hundred-eleven consecu...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Berretta M,Aprile G,Nasti G,Urbani M,Bearz A,Lutrino S,Foltran L,Ferrari L,Talamini R,Fiorica F,Lleshi A,Canzonieri V,Lestuzzi C,Borsatti E,Fisichella R,Tirelli U

更新日期：2013-11-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a cancer with extremely poor prognosis. This review discusses the pathological characteristics of multi-step hepatocarcinogenesis, tumor growth, invasion and metastasis, the expression of matrix metalloproteinases (MMPs) and their inhibitors via signal transduction in relation to dedi...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Okazaki I,Inagaki Y

更新日期：2012-09-01 00:00:00

abstract：:Acetogenins (ACG) are naturally occurring compounds that are chemically one of the least investigated families. In the review, we have provided a comprehensive listing of 133 of these compounds for which anti-tumor activity has been documented within the literature. We have compiled and studied their chemical structur...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Mangal M,Khan MI,Agarwal SM

更新日期：2015-01-01 00:00:00

abstract：:Histone deacetylase inhibitors (HDACIs) represent one of the most promising, recently developed classes of anticancer agents already approved by the U.S. FDA. The effectiveness of these new drugs has currently being explored in a variety of cancer cell lines, in vitro, animal models, in vivo, as well as in clinical tr...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Katafygiotis P,Giaginis C,Patsouris E,Theocharis S

更新日期：2013-03-01 00:00:00

abstract：:Breast cancer is the most common cancer among women, and ranks second among cancer deaths in women. Approximately 60% of all breast cancer patients have hormone-dependent breast cancer, which contains estrogen receptors and requires estrogen for tumor growth. Estradiol is biosynthesized from androgens by the cytochrom...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Díaz-Cruz ES,Brueggemeier RW

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Using imatinib, a tyrosine kinase inhibitor drug used in lymphoblastic leukemia, has always had limitations due to its cardiotoxicity and hepatotoxicity side effects. The objective of this study is to develop a target-oriented drug carrier to minimize these adverse effects by the controlled release of the dr...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Varshosaz J,Fardshouraki S,Mirian M,Safaeian L,Jandaghian S,Taymouri S

更新日期：2020-01-01 00:00:00

abstract：:Sphingolipids are major constituents of the cells with emerging roles in the regulation of cellular processes. Deregulation of sphingolipid metabolism is reflected as various pathophysiological conditions including metabolic disorders and several forms of cancer. Ceramides, ceramide-1-phosphate (C1P), glucosyl ceramid...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ekiz HA,Baran Y

更新日期：2011-05-01 00:00:00

abstract：:Cancer is one of the most fatal diseases in the world and it has been years that finding new drugs and chemotherapeutic techniques with lowest side effects become one of the most important challenging matters needs really hard efforts. Chlorambucil (CBL), an ancient direct-acting alkylating anticancer agent, is common...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Tabasi MA,Amanlou M,Siadat SD,Nourmohammadi Z,Omoomi FD,Ebrahimi SE,Aghasadeghi MR,Rahimi P,Pourhosseini S,Mehravi B,Ardestani MS

更新日期：2013-11-01 00:00:00

abstract：:As cancers are one of the most important causes of human morbidity and mortality worldwide, researchers try to discover novel compounds and therapeutic approaches to decrease survival of cancer cells, angiogenesis, proliferation and metastasis. In the last decade, use of special phytochemical compounds and flavonoids ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Hosseinzadeh E,Hassanzadeh A,Marofi F,Alivand MR,Solali S

更新日期：2020-01-01 00:00:00

abstract：AIM:This study aimed to characterize the cellular basis of the platinum cytotoxicity of two novel platinum complexes, 3Pt and 1Pt, in comparison with that of cisplatin. 3Pt comprises anionic phosphate moieties, while 1Pt comprises neutral aromatic ligands. METHODS:We compared the cytotoxic potency of 3Pt and 1Pt with ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Igarashi K,Yamamoto N,Hayashi K,Takeuchi A,Miwa S,Odani A,Tsuchiya H

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The present study was carried out to evaluate the anticancer property of an alkylamino phenol derivative -2-((3,4-Dihydroquinolin-1(2H)-yl)(p-tolyl)methyl)phenol) (THTMP) against human breast cancer cells. The cytotoxicity of the THTMP was assessed to know its specificity towards breast cancer ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Palanivel S,Yli-Harja O,Kandhavelu M

更新日期：2020-01-01 00:00:00

abstract：:The Src family of kinases has nine known members, all of which are nonreceptor tyrosine kinases involved in signal transduction in both normal and cancer cells. Interest in these kinases has increased recently because of the development, initial clinical success, and low toxicity of pharmacologic inhibitors. c-Src is ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Johnson FM,Gallick GE

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Gemin D (GD) is an ellagitannin found in several plant species rich in phenolic compounds. Its many beneficial properties include antioxidant and antitumoral. OBJECTIVE:The present study assessed the genotoxicity, cytotoxicity, antigenotoxicity, and anticytotoxicity of GD by in vitro and in vivo assays. ME...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Carneiro CC,de Moraes-Filho AV,Fernandes AS,da Costa Santos S,de Melo E Silva D,Chen LC

更新日期：2017-01-01 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) is a central controller of cell growth, proliferation, metabolism and angiogenesis. mTOR signaling is often dysregulated in various human diseases and thus attracts great interest in developing drugs that target mTOR. Currently it is known that mTOR functions as two complexes, mTOR...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Zhou H,Luo Y,Huang S

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:The cause of cervical cancer can be traced to Human Papilloma Virus (HPV) along with other, nonviral factors. The uterine cervix is reactive to hormones, and female hormones have been implicated in cervical cancer pathogenesis. Previous studies have indicated that malignant cervical cells tend to lose Estrog...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Yu P,Wang Y,Li C,Lv L,Wang J

更新日期：2018-01-01 00:00:00

abstract：:Epigenetic modifications can affect numerous mechanisms used by neoplastic cells to evade immune control. In melanoma epigenetic defects, caused by dysregulations in the expression of genome writers, erasers, or readers, play a significant role in the reduced expression of molecules required for efficient immune recog...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Venza M,Visalli M,Catalano T,Beninati C,Teti D,Venza I

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Peniciketal A (Pe-A), a spiroketal compound, shows potent anticancer activities in human acute monocytic leukemia. However, the detailed mechanisms and potent targets of Pe-A remain largely unexplored. Here, we investigated the differentially expressed proteins between the Pe-A-treated group and the control ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Gao X,Zhou Y,Sun H,Liu D,Zhang J,Zhang J,Liu W,Pan X

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Acute myeloid leukemia is the collective name for different types of leukemias of myeloid origin affecting blood and bone marrow. The overproduction of immature myeloblasts (white blood cells) is the characteristic feature of AML, thus flooding the bone marrow and reducing its capacity to produce normal bloo...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Dogra R,Bhatia R,Shankar R,Bansal P,Rawal RK

更新日期：2018-01-01 00:00:00

abstract：:The therapeutic potential of targeting p21-Activated Kinases (PAK1 - 6) for the treatment of cancer has recently gained traction in the biotech industry. Many pharmaceutically-viable ATP competitive inhibitors have been through different stages of pre-clinical development with only a single compound evaluated in human...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Senapedis W,Crochiere M,Baloglu E,Landesman Y

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:High-risk human papillomavirus (HR-HPV) persistent infection is the main cause of cervical cancer and its precancerous lesions. A previous study showed that HPV16 and HPV58 infections were the most common infection types in the local region. Some studies also declared that HPV58 E7 variants increased the ris...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Tian S,Zhang L,Li Y,Cao D,Quan S,Guo Y,Yang X,Yang T

更新日期：2020-11-05 00:00:00

abstract：OBJECTIVE AND METHOD:A new series of benzothiazole-piperazine derivatives was synthesized and a complete chemical characterization of the novel compounds was provided. In vitro cytotoxic activities were screened against colorectal (HCT-116), breast (MCF-7) and hepatocellular (Huh7) cancer cell lines by Sulforhodamine B...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Gurdal EE,Turgutalp B,Gulcan HO,Ercetin T,Sahin MF,Durmaz I,Atalay RC,Nguyen QD,Sippl W,Yarim M

更新日期：2017-01-01 00:00:00

abstract：:Protein kinase B (PKB or Akt) is a central component of the PI3K - PKB - mTOR signalling cascade and is firmly established as an attractive target for pharmacological intervention in cancer. A number of small molecule inhibitors with well-defined, direct molecular interactions with PKB are now known, covering a range ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Collins I

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Lung cancer is one of the most prevalent malignancies and thus the development of novel therapeutic agents for managing lung cancer is imperative. Tetrandrine, a bis-benzyltetrahydroisoquinoline alkaloid isolated from Stephania tetrandra S. Moore, has been found to exert cytotoxic effects on cancerous cells....

journal_title：Anti-cancer agents in medicinal chemistry

authors： Niu N,Qu T,Xu J,Lu X,Bodwell GJ,Zhao Z

更新日期：2019-01-01 00:00:00

abstract：:Tea catechins exhibit a broad range of pharmacological activities that impart beneficial effects on human health. Epigallocatechin-3-gallate (EGCG), one of the major tea catechins, has been widely associated with cancer prevention and treatment. In addition, tea catechins in combination with anticancer drugs are being...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Shang W,Lu W,Han M,Qiao J

更新日期：2014-01-01 00:00:00

abstract：:Cancer is the main cause of death, so the search for active agents to be used in the therapy of this disease, is necessary. According to studies conducted, substances derived from natural products have shown to be promising in this endeavor. To these researches, one can associate with the aid of computational chemistr...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Cavalcanti ÉBVS,Félix MB,Scotti L,Scotti MT

更新日期：2019-01-01 00:00:00

abstract：:In human pathologies, therapeutic treatments are often limited by the lack of selectivity of drugs and their elevated effective concentrations. Targeting these agents to a defined tissue could enhance their selectivity and then diminish their side effects when compared to drugs that accumulate in the entire body. Targ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Schmitt F,Juillerat-Jeanneret L

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Curcumin is a natural polyphenol and lead compound of the rhizomes of curcuma longa that it has been widely used for pharmacological activities. OBJECTIVE:In this study, series of novel derivatives of curcumin, which this group was linked to a 2-amino-4-phenylpyran-3-carbonitrile system, have been synthesiz...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Arjomandi OK,Almasi S,Hosseinzadeh L,Kavoosi M,Adibi H

更新日期：2020-10-02 00:00:00